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Schwellungsänderungen in der Nase

Die bilaterale nasale Remissionsspektroskopie zum seitengetrennten Echtzeit-Monitoring

Bilateral nasal remission spectroscopy allows the side separated continuous measurement of changes in swelling of the nasal mucosa

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Zusammenfassung

Einleitung

Mittels der optischen Transmissionsspektroskopie konnte in früheren Studien gezeigt werden, dass ein kontinuierliches Monitoring von Schwellungsveränderungen der Nasenschleimhaut möglich ist. Mit diesem Verfahren gelingt jedoch keine kontinuierliche, seitengetrennte Messung von Schwellungsänderungen beider Nasenseiten. Mit dem Ziel eines seitengetrennten kontinuierlichen Monitorings von endonasalen Schwellungsveränderungen wurde für diese Pilotstudie die nasale Remissionsspektroskopie entwickelt.

Material und Methoden

Bei der nasalen Remissionsspektroskopie wird in jede Nasenseite Licht der Wellenlänge 790 nm (isobestischer Punkt des Hämoglobins) eingestrahlt und an der gleichen Nasenseite das von den Nasenbinnenstrukturen rückgestreute Licht kontinuierlich gemessen. Zur Evaluierung des Messprinzips wurden an 5 gesunden Probanden einseitige nasale Histaminprovokationen (0,14 ml; 2 mg/ml) durchgeführt.

Ergebnisse

Bei allen Probanden kam es zu einem Anstieg der Lichtextinktion der provozierten Nasenseite um durchschnittlich 0,18 optische Dichten (OD). Bei 4 der 5 getesteten Probanden kam es ebenfalls zu einem geringen Anstieg der Lichtextinktion der nicht provozierten Seite um durchschnittlich 0,04 OD.

Schlussfolgerungen

Mittels der nasalen Remissionsspektroskopie scheint ein seitengetrenntes kontinuierliches Schwellungsmonitoring beider Nasenseiten möglich zu sein. Das Verfahren könnte damit außer zur Objektivierung nasaler Allergenprovokationstests auch für Untersuchungen zum nasalen Zyklus geeignet sein.

Abstract

Introduction

In earlier studies optical transmission spectroscopy showed that continuous monitoring of changes in the swelling of the nasal mucosa is possible. However, independent measurement in both sides of the nose cannot be achieved by this method. With the aim of achieving real-time monitoring of endonasal swelling separately for both nostrils we developed the new method of bilateral nasal remission spectroscopy for this pilot study.

Materials and methods

In nasal remission spectroscopy, light at a wavelength of 790 nm (close to the isobestic point of hemoglobin) is beamed into each side of the nose, and the light that is backscattered by the internal nasal tissue is measured continuously on the same nasal side. To evaluate the principle of this new method a pilot study was conducted in five healthy probands subjected to a one-sided (unilateral) nasal histamine provocation test (0.14 ml, 2 mg/ml).

Results

In each proband single-sided nasal histamine provocation led to an increase in light extinction on the provoked side by an average of 0.18 optical densities (OD). In four of the five probands a slight increase (0.04 OD) in light extinction was observed on the other side of the nose.

Conclusion

Nasal remission spectroscopy seems to allow single-side, continuous monitoring on both sides of the nose. Therefore, the method could also be suitable for use in studies of the nasal cycle, as well as for objectivisation of nasal allergen provocation tests.

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Authors and Affiliations

  1. Universitäts-HNO-Klinik, Fetscherstraße 74, 01307, Dresden

    E. G. Wüstenberg & T. Zahnert

  2. Forschungszentrum Rossendorf, Dresden

    U. Hampel & E. Schleicher

  3. Universitäts-HNO-Klinik, Köln

    K.-B. Hüttenbrink

Authors
  1. E. G. Wüstenberg
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  2. U. Hampel
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  3. E. Schleicher
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  4. K.-B. Hüttenbrink
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  5. T. Zahnert
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Corresponding author

Correspondence to E. G. Wüstenberg.

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Wüstenberg, E.G., Hampel, U., Schleicher, E. et al. Schwellungsänderungen in der Nase. HNO 55, 254–257 (2007). https://doi.org/10.1007/s00106-006-1451-2

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