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Zentrales Riesenzellgranulom des Unterkiefers

Begriffsbestimmung und Differenzialdiagnose

Central giant cell granuloma of the mandible

Definition and differential diagnosis

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Zusammenfassung

Aus der Synopsis von Bildgebung (uni- oder multilokuläre Osteolyse), Morphologie (Riesenzellen in einem fibrösen Stroma ohne zytologische Atypie) sowie laborchemischem (kein erhöhtes Parathormon) und chirurgischem Befund ist eine sichere Diagnosestellung zentraler Riesenzellgranulome möglich, die eine begrenzte chirurgische Therapie erlaubt. Am Fallbeispiel einer 48-jährigen Patientin wird über ein zentrales Riesenzellgranulom der rechten Mandibula berichtet. Auf einen möglichen Wandlungsprozess der Therapie von der radikal-chirurgischen Entfernung der Läsion unter Erhaltung der Funktion hin zu medikamentösen Therapieoptionen wird hingewiesen.

Abstract

The synopsis of radiographic examination (uni- or multilocular radiolucency), histologic findings (giant cells throughout a benign fibroblastic matrix), blood chemistry analysis (normal serum parathyroid hormone) and clinical features provides the definitive diagnosis of giant cell granuloma, allowing the clearly defined surgical management of this lesion. The case history of a 48-year-old female patient who presented with a giant cell granuloma in the right mandible is used to illustrate this controversially discussed intra-osseous lesion. The potential therapeutic change from radical operative treatment, including functional maintenance, to conservative procedures is emphasized.

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Authors and Affiliations

  1. Klinik und Poliklinik für Mund-, Kiefer- und Gesichtschirurgie, Universität Regensburg

    O. Driemel

  2. Klinik und Poliklinik für Hals-Nasen-Ohren-Heilkunde, Universität Regensburg

    R. Staudenmaier

  3. Institut für Pathologie, HELIOS-Klinikum Erfurt

    K. Hertel & H. Kosmehl

  4. Klinik für Mund-, Kiefer- und Gesichtschirurgie/Plastische Operationen, HELIOS-Klinikum Erfurt

    H. Pistner

  5. Klinik und Poliklinik für Mund-, Kiefer- und Gesichtschirurgie, Klinikum der Universität Regensburg, Franz-Josef-Strauß-Allee 11, 93053, Regensburg

    O. Driemel

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  2. R. Staudenmaier
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  3. K. Hertel
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Correspondence to O. Driemel.

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Driemel, O., Staudenmaier, R., Hertel, K. et al. Zentrales Riesenzellgranulom des Unterkiefers. HNO 54, 705–708 (2006). https://doi.org/10.1007/s00106-005-1340-0

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  • DOI: https://doi.org/10.1007/s00106-005-1340-0

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