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Speicheldrüsenkarzinome

Teil II: Diagnostik und Therapie

Salivary gland carcinomas

Part II. Diagnosis and therapy

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Zusammenfassung

Karzinome der Kopfspeicheldrüsen umfassen eine Gruppe seltener maligner Tumoren, deren Diagnostik und Therapie anspruchsvoll sind. Gründe dafür sind die histologische Vielfalt, die den unterschiedlichen Typen entsprechend verschiedenen Krankheitsverläufe und die enge Beziehung zum N. facialis. Die vorliegende Arbeit gibt einen Überblick über Diagnostik und mögliche Therapieverfahren wie Primärtumorresektion, Neck-Dissection sowie Radiatio und analysiert die gegenwärtig diskutierten Risikofaktoren, Malignitätskriterien und Prognoseparameter vor dem Hintergrund der einschlägigen Literatur. Sie beschreibt zudem übersichtsartig klinisch-epidemiologische Daten von Patienten mit Speicheldrüsenkarzinomen, die von 1978 bis 2003 in einem Tumorregister dokumentiert wurden. Die Fortbildung ist in 2 Teile untergliedert: Der erste hat Epidemiologie, Ätiologie, Malignitätskriterien, Prognoseparameter und Klassifikation zum Inhalt, der zweite befasst sich mit der Diagnostik und Therapie von Speicheldrüsenkarzinomen.

Abstract

Salivary gland carcinomas comprise a rare group of malignant tumors which are difficult to diagnose and treat due to their histopathologic diversity, variable clinical course and anatomic location, particularly with respect to the facial nerve. The present paper summarizes important features of these tumors, including recent advances in their management, i.e., diagnosis, surgery of the primary tumor, neck dissection, radiation therapy, and updates risk factors, criteria of malignancy, and prognostic variables, taking into account the relevant literature. Additionally, the present paper highlights briefly the survival rates of patients suffering from salivary gland carcinomas. The present overview is divided into two parts: the first is focused on epidemiology, etiology, criteria of malignancy, prognostic factors, and tumor classification, while part II discusses the diagnosis and therapy of salivary gland carcinomas.

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Authors and Affiliations

  1. Klinik und Poliklinik für Hals-, Nasen- und Ohrenheilkunde, Universitätsklinikum Schleswig-Holstein — Campus Lübeck

    S. Lang, N. Rotter, B. Wollenberg & K. Sommer

  2. Klinik und Poliklinik für Hals-, Nasen- und Ohrenheilkunde der Ludwig-Maximilians-Universität München

    A. Lorenzen & G. Rasp

  3. Pathologisches Institut der Ludwig-Maximilians-Universität München

    S. Ihrler

  4. Tumorregister München

    R. Eckel & D. Hölzel

  5. Klinik und Poliklinik für Hals-, Nasen- und Ohrenheilkunde, Universitätsklinikum Schleswig-Holstein — Campus Lübeck, Ratzeburger Allee 160, 23538, Lübeck

    S. Lang

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Lang, S., Rotter, N., Lorenzen, A. et al. Speicheldrüsenkarzinome. HNO 53, 905–913 (2005). https://doi.org/10.1007/s00106-005-1294-2

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