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HPV-assoziierte Tonsillenkarzinome

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Zusammenfassung

Etablierte Risikofaktoren für die Entwicklung von Kopf-Hals-Karzinomen sind der chronische Nikotin- und Alkoholkonsum. Zwar wurde schon länger vermutet, dass humane Papillomviren (HPV) ebenfalls eine Rolle spielen könnten, aber erst kürzlich veröffentlichte Studien geben eine ausreichende Grundlage, dass die Infektion mit onkogenen [High-risk- (HR-)] HPV als Risikofaktor für die Entwicklung von Kopf-Hals-Karzinomen anzusehen ist. Mindestens die Hälfte aller Tonsillenkarzinome enthalten HR-HPV. Für das Zervixkarzinom wurde die HPV-induzierte Karzinogenese intensiv untersucht, und zunehmend können Parallelen für das Tonsillenkarzinom nachgewiesen werden. Die vorliegende Übersicht stellt hierzu den aktuellen Wissensstand dar und fasst die bisher bekannten molekularbiologischen Aspekte hierzu zusammen. Die Abgrenzung der HPV-positiven Kopf-Hals-Karzinome gewinnt zunehmend an klinischer Bedeutung, da der HPV-Status der Karzinome sowohl Auswirkungen auf Risikofaktoren als auch auf die Prognose hat.

Abstract

The major risk factors for head and neck squamous cell carcinomas (HNSCC) are considered to be tobacco and alcohol. A link between oncogenic types of the human papilloma virus (HPV) and the risk of HNSCC has been suggested in the literature. However, the causal link is now becoming more firmly established on the basis of recent analyses. About 20% of all HNSCC and more than 50% of tonsillar cancers contain HR-HPV. The causal role of HPV-infection in carcinogenesis and the molecular mechanisms involved could thus far be best elucidated in the case of cervical carcinomas. New insights and increasing evidence for the analogy of HPV-positive HNSCC with cervical cancer are discussed. The definition of HPV-positive HNSCC has become more important due to the implications for risk factors and prognosis.

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Authors and Affiliations

  1. Klinik und Poliklinik für Hals-Nasen-Ohren-Heilkunde des Klinikum der Universität zu Köln

    J. P. Klussmann, S. Dinh, O. Guntinas-Lichius & C. Wittekindt

  2. Institut für Virologie der Universität zu Köln

    S. Weißenborn, U. Wieland & H. J. Pfister

  3. Institut für Pathologie der Universität zu Köln

    H. P. Dienes

  4. Klinik und Poliklinik für Hals-Nasen-Ohren-Heilkunde der Universität Düsseldorf

    T. Hoffmann

  5. Department of Epidemiology, University of Iowa, Iowa City, USA

    E. Smith

  6. Department of Pathology, University of Iowa, Iowa City, USA

    L. Turek

  7. Department of Molecular Cell Biology, Research Institute Growth and Development, University of Maastricht, Niederlande

    E. J. M. Speel

  8. HNO-Klinik der Universität zu Köln, 50924 , Köln

    J. P. Klussmann

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  1. J. P. Klussmann
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Klussmann, J.P., Dinh, S., Guntinas-Lichius, O. et al. HPV-assoziierte Tonsillenkarzinome. HNO 52, 208–218 (2004). https://doi.org/10.1007/s00106-004-1069-1

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