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HNO

, Volume 52, Issue 2, pp 175–192 | Cite as

Möglichkeiten und Grenzen der Fluoreszenzdiagnostik und photodynamischen Therapie

Teil 2: Photodynamische Therapie
Weiterbildung · Zertifizierte Fortbildung

Zusammenfassung

Die photodynamische Therapie ist ein Verfahren, bei der neoplastisches Gewebe nach Verabreichung tumorselektiver Photosensibilisatoren und gezielter Lichtbestrahlung eine toxische Schädigung erfährt und zugrunde geht. Entsprechend dem 1. Teil dieser Kurzserie (Fluoreszenzdiagnostik) in der „HNO“ 12/2003 ist es erneut Ziel der vorliegenden Übersichtsarbeit, diese komplexe Thematik mit allen HNO-relevanten Aspekten ausführlich, aber dennoch lesernah darzustellen. Zunächst erfolgt eine nähere Erläuterung der klinischen Problematik bei der Therapie (prä)maligner Läsionen im Kopf-Hals-Bereich, ein geschichtlicher Abriss der Entwicklung dieser therapeutischen Methode sowie eine Veranschaulichung der biophysikalischen Grundlagen. Kernpunkt der Arbeit ist jedoch wiederum die Darstellung des aktuellen Forschungsstands und die Vorstellung bereits länderübergreifend zugelassener Verfahren. Abschließend wird ein kurzer Ausblick auf mögliche weiterführende Entwicklungen auf diesem Gebiet gegeben.

Schlüsselwörter

Übersicht Photodynamische Therapie (PDT) Kopf-Hals-Malignome Rezidivierende respiratorische Papillomatose (RRP) Aktinische Keratosen (AK) 

Abstract

In photodynamic therapy, neoplastic tissue is damaged and subsequently killed by the targeted illumination of previously photosensitized cells. This review is aimed at a comprehensive, but still easily understandable, presentation of all of the aspects of these methods relevant to ENT-doctors. Initially, an explanation of the clinically relevant difficulties in the therapy of (pre-)malignant lesions of the head and neck region, a historical synopsis of the development of this method and an illustration of the biophysical basics is given. The main part of the publication, however, revolves around the description of the current status of research and a presentation of internationally approved methods. At the end, a short overview of possible future developments in this field is given.

Keywords

Review Photodynamic therapy (PDT) Head and neck cancer Recurrent respiratory papillomatosis (RRP) Actinic keratosis (AK) 

Notes

Interessenkonflikt:

Der korrespondierende Autor versichert, dass keine Verbindungen mit einer Firma, deren Produkt in dem Artikel genannt ist, oder einer Firma, die ein Konkurrenzprodukt vertreibt, bestehen.

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Copyright information

© Springer-Verlag 2004

Authors and Affiliations

  1. 1.Klinik für Hals-, Nasen- und Ohren-Heilkunde der Ludwig-Maximilians-Universität München—Klinikum GroßhadernGermany
  2. 2.Klinik für Hals-, Nasen- und Ohren-Heilkunde der Ludwig-Maximilians-Universität München—Klinikum GroßhadernMünchenGermany

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