Literatur
Bosch FX, Homann N, Conradt C, Dietz A, Erber R (1999) Differenzielle Bedeutung des genetischen Status und der Überexpression des p53-Tumorsuppressorgens für die Progression von Kopf-Hals-Karzinomen. HNO 47/9: 833–848
Clayman GL, el-Naggar AK, Lippman SM et al. (1998) Adenovirus-mediated p53 gene transfer in patients with advanced recurrent head and neck squamous cell carcinoma. J Clin Oncol 16/6: 2221–2232
Clayman GL, el-Naggar AK, Roth JA et al. (1995) In vivo molecular therapy with p53 adenovirus for microscopic residual head and neck squamous carcinoma. Cancer Res 55/1: 1–6
Erber R, Conradt C, Homann N et al. (1998) TP53 DNA contact mutations are selectively associated with allelic loss and have a strong clinical impact in head and neck cancer. Oncogene 16: 1671–1679
Förstermann U (2003) Gentherapie: Erste Erfolge—viele noch unerfüllte Hoffnungen. Dtsch Ärztebl 100: A-314–318
Hauser U, Balz V, Carey TE et al. (2002) Reliable detection of p53 aberrations in squamous cell carcinomas of the head and neck requires transcript analysis of the entire coding region. Head Neck 24/9: 868–873
Homann N, Nees M, Conradt C et al. (2001) Overexpression of p53 in tumor-distant epithelia of head and neck cancer patients is associated with an increased incidence of second primary carcinoma. Clin Cancer Res 7/2: 290–296
KunzC, BoschFX, Klein-KühneW et al. (2003) Prognostische Bedeutung der immunhistochemischen Bestimmung von Zellzykluskomponenten bei fortgeschrittenen Plattenepithelkarzinomen des Kopf-Hals-Bereichs. HNO (im Druck)
Nemunaitis J, Swisher SG, Timmons T et al. (2000) Adenovirus-mediated p53 gene transfer in sequence with cisplatin to tumors of patients with non-small-cell lung cancer. J Clin Oncol 18/3: 609–622
Nemunaitis J, Clayman GL, Goodwin WJ et al. (2003) Randomized phase II study of INGN 201 administered by intratumoral injection in recurrent squamous cell carcinoma of the head and neck. J Clin Oncol (in press)
Zhang WW, Roth JA(1994) Anti-oncogene and tumor suppressor gene therapy-examples from a lung cancer animal model. In Vivo 8/5: 755–769
Zhang WW, Alemany R, Wang J, Koch PE, Ordonez NG, Roth JA (1995) Safety evaluation of Ad5CMV-p53 in vitro and in vivo. Hum Gene Ther 6/2: 155–164
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Dietz, A., Esser, D., Helbig, M. et al. Gentherapie mit p53-Tumorsuppressorgen. HNO 51, 365–368 (2003). https://doi.org/10.1007/s00106-003-0850-x
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00106-003-0850-x