Skip to main content
Log in

Gentherapie mit p53-Tumorsuppressorgen

  • Im Fokus
  • Published:
HNO Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Abb. 1.
Abb. 2.
Abb. 3.

Literatur

  1. Bosch FX, Homann N, Conradt C, Dietz A, Erber R (1999) Differenzielle Bedeutung des genetischen Status und der Überexpression des p53-Tumorsuppressorgens für die Progression von Kopf-Hals-Karzinomen. HNO 47/9: 833–848

  2. Clayman GL, el-Naggar AK, Lippman SM et al. (1998) Adenovirus-mediated p53 gene transfer in patients with advanced recurrent head and neck squamous cell carcinoma. J Clin Oncol 16/6: 2221–2232

  3. Clayman GL, el-Naggar AK, Roth JA et al. (1995) In vivo molecular therapy with p53 adenovirus for microscopic residual head and neck squamous carcinoma. Cancer Res 55/1: 1–6

  4. Erber R, Conradt C, Homann N et al. (1998) TP53 DNA contact mutations are selectively associated with allelic loss and have a strong clinical impact in head and neck cancer. Oncogene 16: 1671–1679

  5. Förstermann U (2003) Gentherapie: Erste Erfolge—viele noch unerfüllte Hoffnungen. Dtsch Ärztebl 100: A-314–318

  6. Hauser U, Balz V, Carey TE et al. (2002) Reliable detection of p53 aberrations in squamous cell carcinomas of the head and neck requires transcript analysis of the entire coding region. Head Neck 24/9: 868–873

  7. Homann N, Nees M, Conradt C et al. (2001) Overexpression of p53 in tumor-distant epithelia of head and neck cancer patients is associated with an increased incidence of second primary carcinoma. Clin Cancer Res 7/2: 290–296

  8. KunzC, BoschFX, Klein-KühneW et al. (2003) Prognostische Bedeutung der immunhistochemischen Bestimmung von Zellzykluskomponenten bei fortgeschrittenen Plattenepithelkarzinomen des Kopf-Hals-Bereichs. HNO (im Druck)

  9. Nemunaitis J, Swisher SG, Timmons T et al. (2000) Adenovirus-mediated p53 gene transfer in sequence with cisplatin to tumors of patients with non-small-cell lung cancer. J Clin Oncol 18/3: 609–622

  10. Nemunaitis J, Clayman GL, Goodwin WJ et al. (2003) Randomized phase II study of INGN 201 administered by intratumoral injection in recurrent squamous cell carcinoma of the head and neck. J Clin Oncol (in press)

  11. Zhang WW, Roth JA(1994) Anti-oncogene and tumor suppressor gene therapy-examples from a lung cancer animal model. In Vivo 8/5: 755–769

  12. Zhang WW, Alemany R, Wang J, Koch PE, Ordonez NG, Roth JA (1995) Safety evaluation of Ad5CMV-p53 in vitro and in vivo. Hum Gene Ther 6/2: 155–164

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to A. Dietz.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Dietz, A., Esser, D., Helbig, M. et al. Gentherapie mit p53-Tumorsuppressorgen. HNO 51, 365–368 (2003). https://doi.org/10.1007/s00106-003-0850-x

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00106-003-0850-x

Navigation