Zusammenfassung
Fragestellung
Die Studie überprüft einGerät (SilentOne®, Fa. Imperpuls, Chemnitz) zur Therapie der obstruktiven Schlafapnoe (OSA) bezüglich seiner Sicherheit, Anwendbarkeit und Effektivität.
Methoden und Ergebnisse
15 Patienten mit OSA wurden einer 4- bis 5-wöchigen transkutanen Elektrostimulationstherapie tagsüber und in der Nacht unterzogen. Anwendbarkeit und unerwünschte Ereignisse wurden mittels Patiententagebuch erfasst. Die Atmungsparameter wurden vorher und nachher in je 2 Polysomnographien objektiviert, Schnarchen und Tagesschläfrigkeit mit Fragebögen subjektiv erfasst. Die Patienten dienten als ihre eigenen Kontrollen.
Fazit
Die transkutane Elektrostimulationstherapie mit dem SilentOne® erwies sich als leicht anwendbar, komplikationsarm und wirksam, aber ohne ausreichend hohe Heilungsraten.
Abstract
Background
Transcutaneous electrical stimulation while asleep has been used to treat obstructive sleep apnea (OSA), although without convincing results. Modern strategies consist of electrical muscle training for a number of weeks during wakefulness rather than stimulation during sleep.
Objective
The purpose of this study was to assess the practicability, safety, and efficacy of a new device, SilentOne (Imperpuls, Chemnitz, Germany).
Patients and methods
Fifteen patients with various degrees of OSA used transcutaneous submental electrical stimulation therapy for 4–5 weeks every day, day and night. A patient's diary recorded practicability and potential adverse events. Respiratory parameters were recorded by fully attended polysomnography in the sleep lab. Daytime sleepiness and snoring were assessed by questionnaires.
Results
The apnea-hypopnea-index decreased from 29.2 before to 21.2 after therapy (P<0.05). Daytime sleepiness improved significantly (P<0.01) as did snoring (P<0.005).
Conclusions
Transcutaneous electrical stimulation therapy using SilentOne proved to be safe, easy to use, and potent. However, therapy showed a limited cure rate.
Literatur
Broniatowski M (1994) The potential for neurostimulation in obstructive sleep apnea. ASAIO J 40: 13–16
Chaban R, Cole P, Hoffstein V (1988) Site of upper airway obstruction in patients with obstructive sleep apnea. Laryngoscope 98: 641–647
Constantinidis J, Knobber D, Steinhart H, Kuhn J, Iro H (2000) Morphologische und funktionelle Veränderungen der Nasenschleimhaut nach nCPAP-Therapie. HNO 48: 747–752
Edmonds LC, Daniels BK, Stanson AW, Sheedy II PF, Shepard JW (1993) The effects of transcutaneous electrical stimulation during wakefulness and sleep in patients with obstructive sleep apnea. Am Rev Respir Dis 146: 1830–1836
Gessmann HW, Hegemann R, Miele S (2001) Das Zungenmuskeltraining (ZMT) bei nCPAP-Patienten mit obstruktivem Schlaf-Apnoe-Syndrom. Eine Zusammenfassung der Studie. PIB, Duisburg,http://www.pib-zentrum.de
Guilleminault C, Dement WC (eds) (1978) Sleep apnea syndrome. Alan R. Liss, New York
Guilleminault C, Powell NB, Bowman B, Stoohs R (1995) The effect of electrical stimulation on obstructive sleep apnea syndrome. Chest 107: 67–73
Guilleminault C, Stoohs R, Clerk J, Simmons J, Labanowski M (1993) A cause of excessive daytime sleepiness: the upper airway resistance syndrome. Chest 104: 781–787
He J, Kryger MH, Zorick FJ, Conway W, Roth T (1988) Mortality and apnea index in obstructive sleep apnea. Experience in 385 male patients. Chest 94: 9–14
Hollandt JH, Kuhl S, Gabler R, Remmert S (2000) Das Upper Airway Resistance Syndrome (UARS)—Obstruktives Schnarchen. HNO 48: 628–634
Ilomaki J, Baer GA, Karhuketo T, Talonen P, Puhakka H (1997) Pharyngeal patency caused by stimulation of the hypoglossal nerve in anaesthesia-relaxed patients. Acta Otolaryngol Suppl 529: 210–211
Johns MW (1991) A new method for measuring daytime sleepiness: the Epworth Sleepiness Scale. Sleep 14: 540–545
Knaack L, Podszus T (1998) Electric stimulation of the upper airway muscle. Curr Opin Pulm Med 4: 370–375
McArdle N, Dervereux G, Heidarnejad H et al. (1999) Long-term use of CPAP therapy for sleep apnea/hypopnea syndrome. Am J Respir Crit Care Med 159: 1108–1114
Miki H, Hida W, Chonan T, Kikuchi Y, Takishima T (1989) Effects of submental electrical stimulation during sleep on upper airway patency in patients with obstructive sleep apnea. Am Rev Respir Dis 140: 1285–1289
Oliven A, Schnall RP, Pillar G, Gavriely N, Odeh M (2001) Sublingual electrical stimulation of the tongue during wakefulness and sleep. Respir Physiol 127: 217–226
Penzel T, Brandenburg U (1996) Diagnostische Verfahren und Standards in der Schlafmedizin. Internist 37: 442–453
Rechtschaffen A, Kales A (eds) (1968) In: A manual of standardized terminology techniques and scoring system for sleep stages in human subjects. Government Printing Office, Washington/DC (NIH publication no. 204)
Schwartz AR, Bennet EL, Smith PL et al. (2001) Therapeutic electrical stimulation of the hypoglossal nerve in obstructive sleep apnea. Arch Otolaryngol Head Neck Surg 127: 1216–1223
Sullivan CE, Issa FG, Berthon-Jones M, Eves L (1981) Reversal of obstructive sleep apnoea by continuous positive airway pressure applied through the nares. Lancet 1: 862–865
Verse T (2000) Nebenwirkungen der nasalen CPAP-Ventilationstherapie. HNO 48: 706–715
Verse T, Pirsig W (2001) Aktuelles zur Diagnostik schlafbezogener Atmungsstörungen. HNO 49: 6-11
Verse T, Pirsig W, Stuck BA, Hörmann K, Maurer JT (2003) Recent developments in the treatment of obstructive sleep apnea. Am J Resp Med 2: 151–168
Wiltfang J, Klotz S, Wiltfang J et al. (1999) First results on daytime submandibular electrostimulation of suprahyoidal muscles to prevent night-time hypopharyngeal collapse in obstructive sleep apnea syndrome. Int J Oral Maxillofac Surg 28: 21–25
Young T, Palat M, Dempsey J et al. (1993) The occurrence of sleep-disordered breathing among middle-aged adults. N Engl J Med 328: 1230–1235
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In Auszügen vorgetragen anlässlich des deutsch-österreichischen HNO-Kongresses vom 8. bis 12. Mai 2002 in Baden-Baden.
Die Arbeit ist ohne finanzielle Unterstützung seitens der Industrie entstanden. Insbesondere bestehen keine vertraglichen oder finanziellen Verbindungen zu den Herstellern der im Artikel beschriebenen Medizinprodukte.
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Verse, T., Schwalb, J., Hörmann, K. et al. Transkutane, submentale Elektrostimulationstherapie bei obstruktiver Schlafapnoe. HNO 51, 966–970 (2003). https://doi.org/10.1007/s00106-003-0842-x
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DOI: https://doi.org/10.1007/s00106-003-0842-x