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Behandlung des Naevus Ota und Ito und des Pigmentnävussyndroms

Treatment of nevus of Ota and Ito and epidermal nevus syndrome

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Zusammenfassung

Naevus Ota, Ito und Hori sind spezielle melanozytäre Nävi von graubrauner oder blaugrauer Farbe. Es sind Pigmentstörungen, die durch ihre heterotope melanozytäre dermale Lage charakterisiert sind und im Falle des Naevus Ota durch blaubraune unilaterale, manchmal bilaterale fleckförmige Struktur im Gesicht, im Falle des Naevus Ito durch Lokalisation supraklavikulär, skapulär und im Deltoidbereich. Sie kommen gehäuft vor bei Patienten aus asiatischen und dunkelhäutigen Ethnien. Histologisch findet man elongierte dendritische Melanozyten, vorwiegend im oberen Drittel der retikulären Dermis. Eine nichtgenetische erworbene Form wird Hori-Nävus genannt, der vorwiegend im Gesicht bilateral vorkommt, ähnlich einem Melasma. Eine dermale Melanozytose kann auch an anderen Stellen des Körpers vorkommen, einschließlich der Mundschleimhaut. Auch wenn diese Veränderungen gutartig sind, suchen Patienten häufig nach einer wirksamen Therapie wegen der Lokalisation im Gesicht. QS(Q-switched)-Laser sind am wirksamsten zur Behandlung dieser Hautveränderungen. Die Anzahl der Behandlungen hängt ab von der klinischen Besserung. Häufige Nebenwirkungen v. a. bei Patienten mit dunkler Haut können Hypo- und Hyperpigmentierungen sein.

Abstract

Nevus of Ota, nevus of Ito and nevus of Hori are special melanocytic nevi that have a slate-brown or blue/grey coloring. They are pigmented disorders characterized by its heterotopic melanocytic dermal location and by blue/brown unilateral and sometimes bilateral facial patch in case of nevus of Ota, and in the supraclavicular, scapular, and deltoid region in case of nevus of Ito. It is more common in patients with Asian and dark-skinned ethnic backgrounds. Histologically, elongated, dendritic melanocytes are seen scattered mainly throughout the upper third of reticular dermis. An acquired variant is called Hori’s nevus with more bilateral facial distribution, similar to melasma. Dermal melanocytosis can also occur elsewhere on the body, including inside the mouth. Despite its benign nature, patients frequently seek therapy because of its facial involvement. QS lasers are used effectively to treat these lesions. The number of treatment sessions correlates with clinical improvement. Post laser hypo- and hyperpigmentation are common side effects mainly affecting patients with darker skin.

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Danksagung

Herzlichen Dank an Herrn Prof. Dr. Klaus Fritz für die Übersetzung des englischen Originalartikels.

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Authors and Affiliations

  1. National Institute of Laser Enhanced Sciences (NILES), Cairo University, Giza, Ägypten

    A. Badawi, M. A. Osman & A. N. Kassab

  2. Dermatology and Allergeology department, Faculty of Medicine, University of Szeged, Szeged, Ungarn

    A. Badawi

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  1. A. Badawi
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  2. M. A. Osman
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  3. A. N. Kassab
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Correspondence to A. Badawi.

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A. Badawi, M.A. Osman und A.N. Kassab geben an, dass kein Interessenkonflikt besteht.

Für diesen Beitrag wurden von den Autoren keine Studien an Menschen oder Tieren durchgeführt. Für die aufgeführten Studien gelten die jeweils dort angegebenen ethischen Richtlinien. Für Bildmaterial oder anderweitige Angaben innerhalb des Manuskripts, über die Patienten zu identifizieren sind, liegt von ihnen und/oder ihren gesetzlichen Vertretern eine schriftliche Einwilligung vor.

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Badawi, A., Osman, M.A. & Kassab, A.N. Behandlung des Naevus Ota und Ito und des Pigmentnävussyndroms. Hautarzt 71, 926–931 (2020). https://doi.org/10.1007/s00105-020-04710-3

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