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Topische Therapie des Pruritus – Tipps und Tricks

Topical therapy of pruritus—tips for daily practice

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Zusammenfassung

Pruritus ist ein häufiges und sehr belastendes Symptom in der Medizin, das sich an dem Hautorgan äußert. Das Management stellt sowohl für den Arzt als auch für den Patienten häufig eine Herausforderung dar, da es viele Ursachen/Trigger und nur wenige zugelassene Therapieoptionen gerade bei Systemtherapeutika gibt. Grundsätzlich stehen zur Therapie 2 Behandlungssäulen zur Verfügung: topische Therapien inklusive Basistherapien für alle Verläufe, bei schweren und vorwiegend chronischen Verläufen additiv Systemtherapeutika. Dieser Beitrag gibt eine Hilfestellung zum praktischen Management der Prurituspatienten.

Abstract

Pruritus is a common and stressful symptom in medicine with cutaneous manifestation. Therapy remains a challenge for physicians and patients because there are many causes/triggers and approved systemic therapies are lacking. Basically, there are two different options of treatment: topical treatment is selected for every degree of severity, while patients with severe symptoms and chronic disease course have to be treated with systemic and topical options. This article provides a summary of current topical therapeutic options and offers tips for daily practice.

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Literatur

  1. Augustin M, Kirsten N, Korber A et al (2019) Prevalence, predictors and comorbidity of dry skin in the general population. J Eur Acad Dermatol Venereol 33:147–150

    Article  CAS  Google Scholar 

  2. Augustin M, Wilsmann-Theis D, Korber A et al (2019) Diagnosis and treatment of xerosis cutis—a position paper. J Dtsch Dermatol Ges 17(Suppl 7):3–33

    Article  Google Scholar 

  3. Bornhovd E, Burgdorf WH, Wollenberg A (2001) Macrolactam immunomodulators for topical treatment of inflammatory skin diseases. J Am Acad Dermatol 45:736–743

    Article  CAS  Google Scholar 

  4. Cury Martins J, Martins C, Aoki V et al (2015) Topical tacrolimus for atopic dermatitis. Cochrane Database Syst Rev. https://doi.org/10.1002/14651858.CD009864.pub2

    Article  PubMed  PubMed Central  Google Scholar 

  5. Elmariah SB, Lerner EA (2011) Topical therapies for pruritus. Semin Cutan Med Surg 30:118–126

    Article  CAS  Google Scholar 

  6. Hay RJ, Johns NE, Williams HC et al (2014) The global burden of skin disease in 2010: an analysis of the prevalence and impact of skin conditions. J Invest Dermatol 134:1527–1534

    Article  CAS  Google Scholar 

  7. Knolle E, Zadrazil M, Kovacs GG et al (2013) Comparison of cooling and EMLA to reduce the burning pain during capsaicin 8 % patch application: a randomized, double-blind, placebo-controlled study. Pain 154:2729–2736

    Article  CAS  Google Scholar 

  8. Lee CH, Chuang HY, Shih CC et al (2006) Transepidermal water loss, serum IgE and beta-endorphin as important and independent biological markers for development of itch intensity in atopic dermatitis. Br J Dermatol 154:1100–1107

    Article  CAS  Google Scholar 

  9. Ng JP, Liew HM, Ang SB (2015) Use of emollients in atopic dermatitis. J Eur Acad Dermatol Venereol 29:854–857

    Article  CAS  Google Scholar 

  10. Ruzicka T, Bieber T, Schopf E et al (1997) A short-term trial of tacrolimus ointment for atopic dermatitis. European Tacrolimus Multicenter Atopic Dermatitis Study Group. N Engl J Med 337:816–821

    Article  CAS  Google Scholar 

  11. Stander S, Schurmeyer-Horst F, Luger TA et al (2006) Treatment of pruritic diseases with topical calcineurin inhibitors. Ther Clin Risk Manag 2:213–218

    Article  Google Scholar 

  12. Szolcsanyi J (2004) Forty years in capsaicin research for sensory pharmacology and physiology. Neuropeptides 38:377–384

    Article  CAS  Google Scholar 

  13. Thaci D, Augustin M, Krutmann J et al (2015) Importance of basic therapy in psoriasis. J Dtsch Dermatol Ges 13:415–418

    PubMed  Google Scholar 

  14. Wallengren J, Hakanson R (1992) Effects of capsaicin, bradykinin and prostaglandin E2 in the human skin. Br J Dermatol 126:111–117

    Article  CAS  Google Scholar 

  15. Weisshaar E, Dalgard F (2009) Epidemiology of itch: adding to the burden of skin morbidity. Acta Derm Venereol 89:339–350

    Article  Google Scholar 

  16. Weisshaar E, Forster C, Dotzer M et al (1997) Experimentally induced pruritus and cutaneous reactions with topical antihistamine and local analgesics in atopic eczema. Skin Pharmacol 10:183–190

    Article  CAS  Google Scholar 

  17. Weisshaar E, Szepietowski JC, Dalgard FJ et al (2019) European S2k Guideline on chronic pruritus. Acta Derm Venereol 99:469–506

    Article  Google Scholar 

  18. Werfel T, Heratizadeh A, Aberer W et al (2016) S2k guideline on diagnosis and treatment of atopic dermatitis—short version. J Dtsch Dermatol Ges 14:92–106

    PubMed  Google Scholar 

  19. Yosipovitch G, Szolar C, Hui XY et al (1996) Effect of topically applied menthol on thermal, pain and itch sensations and biophysical properties of the skin. Arch Dermatol Res 288:245–248

    Article  CAS  Google Scholar 

  20. Zeidler C, Luling H, Dieckhofer A et al (2015) Capsaicin 8 % cutaneous patch: a promising treatment for brachioradial pruritus? Br J Dermatol 172:1669–1671

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Klinik für Hautkrankheiten, Von-Esmarch-Str. 58, 48149, Münster, Deutschland

    S. Salzmann

  2. Hautklinik, Universitätsmedizin Mainz, Mainz, Deutschland

    P. Staubach

Authors
  1. S. Salzmann
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  2. P. Staubach
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Correspondence to S. Salzmann.

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Interessenkonflikt

P. Staubach: Vortragende oder beratende Tätitgkeit für Leti Pharma, Allergika, Karrer, Pflüger, Almirall, Beiersdorf, L’Oréal, Pierre Fabre. S. Salzmann gibt an, dass kein Interessenkonflikt besteht.

Für diesen Beitrag wurden von den Autoren keine Studien an Menschen oder Tieren durchgeführt. Für die aufgeführten Studien gelten die jeweils dort angegebenen ethischen Richtlinien.

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Salzmann, S., Staubach, P. Topische Therapie des Pruritus – Tipps und Tricks. Hautarzt 71, 511–517 (2020). https://doi.org/10.1007/s00105-020-04605-3

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  • DOI: https://doi.org/10.1007/s00105-020-04605-3

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