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Der Hautarzt

, Volume 67, Issue 11, pp 907–921 | Cite as

Epidermale Barrierestörung bei Dermatosen

  • E. Proksch
  • D. Dähnhardt
  • S. Dähnhardt-Pfeiffer
  • R. Fölster-Holst
CME

Zusammenfassung

Die Permeabilitätsbarriere spielt bei zahlreichen Hauterkrankungen eine Rolle. Besonders gut aufgeklärt ist die Bedeutung der Barriere bei ekzematösen Erkrankungen. Bei einem irritativ-toxischen Kontaktekzem ist die Störung der Permeabilitätsbarriere durch irritativ-toxische Noxen der erste Schritt in der Pathogenese. Nur nach Schädigung der Barriere können Irritanzien und Allergene in die lebende Epidermis eindringen. Beim atopischen Ekzem penetrieren aufgrund der gestörten Barriere Typ-I-Allergene aus der Umwelt in die Haut und verursachen oder verschlimmern das Ekzem. Bei der anderen häufigen chronisch entzündlichen Dermatose, der Psoriasis, ist die Rolle der Permeabilitätsbarriere nur teilweise bekannt. Bei einem Exanthem verursachen Infektionserreger oder Medikamente eine systemische Entzündung, wobei der Inflammation der Haut eine Barrierestörung folgt. Prinzipiell liegt bei allen entzündlichen Erkrankungen eine gestörte Permeabilitätsbarriere der Haut vor.

Schlüsselwörter

Permeabilitätsbarriere Ekzem Filaggrin Exanthem Psoriasis 

Epidermal barrier disorders in dermatoses

Abstract

The permeability barrier plays an important role in numerous skin diseases. Particularly well known is the importance of this barrier in eczema. In irritative–toxic contact dermatitis, the first step in the pathogenesis is the disturbance of the permeability barrier by irritative–toxic noxious substances. Only after damage to the barrier is achieved can irritants and allergens penetrate into the living epidermis. In atopic eczema due to an impaired barrier, allergens penetrate from the environment into the skin and cause or worsen the eczema. In psoriasis—the other common chronic inflammatory dermatosis—the role of the permeability barrier is only partly understood. In exanthema, infectious agents or drugs cause systemic inflammation, whereby the inflammation of the skin is followed by a barrier disorder. In principle, disturbed permeability of the skin barrier is present in all inflammatory diseases.

Keywords

Permeability barrier Eczema Filaggrin Exanthema Psoriasis 

Notes

Einhaltung ethischer Richtlinien

Interessenkonflikt

E. Proksch und R. Fölster-Holst geben an, dass kein Interessenkonflikt besteht. D. Dähnhardt und S. Dähnhardt-Pfeiffer sind Gründer und Eigentümer der Firma Microscopy Services Dähnhardt GmbH. Im Zusammenhang mit diesem Beitrag besteht kein Interessenkonflikt.

Dieser Beitrag beinhaltet keine von den Autoren durchgeführten Studien an Menschen oder Tieren.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2016

Authors and Affiliations

  • E. Proksch
    • 1
  • D. Dähnhardt
    • 2
  • S. Dähnhardt-Pfeiffer
    • 2
  • R. Fölster-Holst
    • 1
  1. 1.Klinik für Dermatologie, Allergologie und VenerologieUniversitätsklinikum Schleswig-Holstein, Campus KielKielDeutschland
  2. 2.Microscopy Services Dähnhardt GmbHFlintbekDeutschland

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