Skip to main content
Log in

Spermiogramm bei unerfülltem Kinderwunsch

Was sagt es aus?

Semen analysis in involuntary childlessness

What information does it provide?

  • Leitthema
  • Published:
Der Hautarzt Aims and scope Submit manuscript

Zusammenfassung

Unerfüllter Kinderwunsch ist ein häufiges Problem. In etwa der Hälfte der Fälle spielt dabei eine eingeschränkte Spermienqualität eine relevante Rolle. Das Spermiogramm spiegelt die exokrine Funktion der männlichen reproduktiven Organe Hoden, Nebenhoden, Bläschendrüsen, Prostata und Samenleiter wider. Es ist aber nur zusammen mit der Anamnese und körperlichen Untersuchung geeignet, relevante Störungen und häufig auch deren Ursachen zu identifizieren. Dabei ist die grundlegende Interpretation eines Spermiogramms leicht zu erlernen und gehört traditionell in das Handwerkszeug der Dermatologie. Dieser Beitrag erläutert die für ein Routinespermiogramm zu erhebenden Parameter mit ihren Referenzwerten. Darüber hinaus werden häufige Ursachen für etwaige Abweichungen besprochen, um weitere andrologische Schritte veranlassen zu können. Die Interpretation der Fertilität geschieht dabei immer vor dem Hintergrund der Paarkonstellation.

Abstract

Involuntary childlessness is a common problem. In about 50 % of cases, inadequate semen quality plays a relevant role. A semen analysis provides information regarding exocrine function of the male reproductive organs of the testes, epidydimis, seminal vesicles, prostate gland, and vas deferens. These parameters can only be interpreted in conjunction with medical history and physical examination. Then they can be useful to identify relevant disorders or the causes of these disturbances. The fundamental principles for the interpretation of a semen analysis are easily learned and traditionally belong to the field of dermatology. This article explains the variables which are examined in a routine semen analysis as well as the reference values. Furthermore, common causes for deviations from the normal values are discussed to allow decision-making for further diagnostic workup. The interpretation of these values must always take into account the situation of the couple.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Abb. 1
Abb. 2

Literatur

  1. Greenhall E, Vessey M (1990) The prevalence of subfertility: a review of the current confusion and a report of two new studies. Fertil Steril 54(6):978–983

    CAS  PubMed  Google Scholar 

  2. Irvine DS (1998) Epidemiology and aetiology of male infertility. Hum Reprod 13(Suppl 1):33–44

    Article  PubMed  Google Scholar 

  3. Zegers-Hochschild F et al (2009) International Committee for Monitoring Assisted Reproductive Technology (ICMART) and the World Health Organization (WHO) revised glossary of ART terminology, 2009. Fertil Steril 92(5):1520–1524

    Article  CAS  PubMed  Google Scholar 

  4. Jungwirth A et al (2012) European Association of Urology guidelines on Male Infertility: the 2012 update. Eur Urol 62(2):324–332

    Article  PubMed  Google Scholar 

  5. Bundesärztekammer (Arbeitsgemeinschaft der deutschen Ärztekammern) (in der Fassung vom 28.6.2013) (Muster-) Weiterbildungsordnung 2003

  6. Scholz A (2009) Die Rolle der Andrologie in der deutschen Dermatologie. In: Scholz A et al (Hrsg) Geschichte der deutschsprachigen Dermatologie. Wiley-VCH, Weinheim, S 527 ff

    Google Scholar 

  7. World Health Organization (2012) WHO Laborhandbuch zur Untersuchung und Aufbereitung des menschlichen Ejakulats, 5. Aufl. Springer, Heidelberg. (korrigierte Sonderausgabe 2014 ed. 2014)

    Google Scholar 

  8. o A (2014) Neufassung der „Richtlinie der Bundesärztekammer zur Qualitätssicherung laboratoriumsmedizinischer Untersuchungen – Rili-BÄK“ – Richtlinie der Bundesärztekammer zur Qualitätssicherung laboratoriumsmedizinischer Untersuchungen. Dtsch Arztebl Int 111(38):1583

    Google Scholar 

  9. Carlsen E et al (2004) Effects of ejaculatory frequency and season on variations in semen quality. Fertil Steril 82(2):358–366

    Article  PubMed  Google Scholar 

  10. Cooper TG et al (2010) World Health Organization reference values for human semen characteristics. Hum Reprod Update 16(3):231–245

    Article  PubMed  Google Scholar 

  11. Ochsendorf F, Beschmann H (1996) Männliche Infertilität. Springer, Heidelberg

    Book  Google Scholar 

  12. Elzanaty S, Malm J, Giwercman A (2004) Visco-elasticity of seminal fluid in relation to the epididymal and accessory sex gland function and its impact on sperm motility. Int J Androl 27(2):94–100

    Article  CAS  PubMed  Google Scholar 

  13. Gonzales GF, Kortebani G, Mazzolli AB (1993) Hyperviscosity and hypofunction of the seminal vesicles. Arch Androl 30(1):63–68

    Article  CAS  PubMed  Google Scholar 

  14. Cooper T (2009) Andrologie.In: Nieschlag E, Behre HM, Nieschlag S (Hrsg) Springer, Heidelberg

  15. Pajovic B et al (2013) Semen analysis before and after antibiotic treatment of asymptomatic Chlamydia- and Ureaplasma-related pyospermia. Andrologia 45(4):266–271

    Article  CAS  PubMed  Google Scholar 

  16. Stone BA et al (2013) Age thresholds for changes in semen parameters in men. Fertil Steril 100(4):952–958

    Article  PubMed  Google Scholar 

  17. Heller CH, Clermont Y (1964) Kinetics of the germinal epithelium in man. Recent Prog Horm Res 20:545–575

    CAS  PubMed  Google Scholar 

  18. Kroese AC et al (2012) Surgery or embolization for varicoceles in subfertile men. Cochrane Database Syst Rev 10:CD000479

    PubMed  Google Scholar 

  19. o A (1992) The influence of varicocele on parameters of fertility in a large group of men presenting to infertility clinics. World Health Organization. Fertil Steril 57(6):1289–1293

    Google Scholar 

  20. World Health Organization Task Force on Methods for the Regulation of Male Fertility (1996) Contraceptive efficacy of testosterone-induced azoospermia and oligozoospermia in normal men. Fertil Steril 65(4):821–829

    Google Scholar 

  21. Lanfranco F et al (2004) Klinefelter’s syndrome. Lancet 364(9430):273–283

    Article  CAS  PubMed  Google Scholar 

  22. Hamilton JA et al (2015) Total motile sperm count: a better indicator for the severity of male factor infertility than the WHO sperm classification system. Hum Reprod 30(5):1110–1121

    Article  CAS  PubMed  Google Scholar 

  23. Chemes EH, Rawe YV (2003) Sperm pathology: a step beyond descriptive morphology. Origin, characterization and fertility potential of abnormal sperm phenotypes in infertile men. Hum Reprod Update 9(5):405–428

    Article  PubMed  Google Scholar 

  24. Garrett C et al (2003) Automated semen analysis: ‚zona pellucida preferred‘ sperm morphometry and straight-line velocity are related to pregnancy rate in subfertile couples. Hum Reprod 18(8):1643–1649

    Article  CAS  PubMed  Google Scholar 

  25. Van Waart J (2001) Predictive value of normal sperm morphology in intrauterine insemination (IUI): a structured literature review. Hum Reprod Update 7(5):495–500

    Article  PubMed  Google Scholar 

  26. Amann RP, Howards SS (1980) Daily spermatozoal production and epididymal spermatozoal reserves of the human male. J Urol 124(2):211–215

    CAS  PubMed  Google Scholar 

  27. Sallam HN et al (2005) The use of the modified hypo-osmotic swelling test for the selection of immotile testicular spermatozoa in patients treated with ICSI: a randomized controlled study. Hum Reprod 20(12):3435–3440

    Article  PubMed  Google Scholar 

  28. Branigan EF, Muller CH (1994) Efficacy of treatment and recurrence rate of leukocytospermia in infertile men with prostatitis. Fertil Steril 62(3):580–584

    CAS  PubMed  Google Scholar 

  29. Merviel P et al (2010) Predictive factors for pregnancy after intrauterine insemination (IUI): an analysis of 1038 cycles and a review of the literature. Fertil Steril 93(1):79–88

    Article  PubMed  Google Scholar 

  30. Badawy A, Elnashar A, Eltotongy M (2009) Effect of sperm morphology and number on success of intrauterine insemination. Fertil Steril 91(3):777–781

    Article  PubMed  Google Scholar 

  31. Roseboom TJ et al (1995) The probability of pregnancy after embryo transfer is affected by the age of the patient, cause of infertility, number of embryos transferred and the average morphology score, as revealed by multiple logistic regression analysis. Hum Reprod 10(11):3035–3041

    CAS  PubMed  Google Scholar 

  32. Abshagen K et al (1998) Influence of sperm surface antibodies on spontaneous pregnancy rates. Fertil Steril 70(2):355–356

    Article  CAS  PubMed  Google Scholar 

  33. Knuth U (2009) Andrologie. In: Nieschlag E, Behre HM, Nieschlag S (Hrsg) Springer, Heidelberg

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to T. Weberschock MSc (Epi).

Ethics declarations

Interessenkonflikt

T. Weberschock, A. Valipour und F. Ochsendorf geben an, dass kein Interessenkonflikt besteht.

Dieser Beitrag beinhaltet keine Studien an Menschen oder Tieren.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Weberschock, T., Valipour, A. & Ochsendorf, F. Spermiogramm bei unerfülltem Kinderwunsch. Hautarzt 66, 924–932 (2015). https://doi.org/10.1007/s00105-015-3707-9

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00105-015-3707-9

Schlüsselwörter

Keywords

Navigation