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Hauteigene Antibiotika

Wichtige Erkenntnisse über antimikrobielle Peptide für Klinik und Praxis

The skin’s own antibiotics

Important features of antimicrobial peptides for clinical practice

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Zusammenfassung

Trotz permanenter Konfrontation mit potenziell schädigenden Einflüssen, eigener mikrobieller Flora und im Alltag häufig vorkommenden kleineren Verletzungen sind Infektionen gesunder Haut selten. Eine chemische Barriere aus konstitutiv exprimierten und durch verschiedene Stimuli induzierbaren antimikrobiellen Peptiden (AMP) trägt zur Widerstandskraft des Integuments bei. AMP sind evolutionär sehr alte Bestandteile der angeborenen Immunabwehr, die aufgrund ihres breiten Wirkspektrums und selten auftretender Resistenzen als antimikrobielle Therapeutika der Zukunft in den Fokus des Interesses gerückt sind. Weiterhin wird einer veränderten Expression dieser Moleküle eine Rolle in der Pathogenese verschiedener Erkrankungen zugeschrieben. Auch über die antimikrobiellen Effekte hinausgehende Wirkungen im Immunsystem oder bei der Wundheilung werden derzeit intensiv erforscht.

Abstract

Despite permanent confrontation with a potentially harmful environment, its own microbiota and the fact that minor injuries occur frequently in everyday life, skin infections are a rare event. A chemical barrier of antimicrobial peptides (AMP), some of them constitutively expressed, others inducible by various stimuli, contributes to the integument’s resistance. AMP are evolutionarily old components of the innate immunity which became the focus of interest due to their broad spectrum of activity against microorganisms and the rare occurrence of antimicrobial resistance. These attributes make them promising alternative candidates for future antibiotics. Furthermore various dermatological diseases are associated with an altered expression of these molecules, which might then play a pathogenetic role. In addition to their antimicrobial activity, some AMP have immunomodulatory effects and can promote wound healing, properties which currently are under intensive research.

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Danksagung

Der Artikel wurde zum Teil mit Mitteln des BMBF („SkinStaph“ im Verbundprojekt „Suszeptibilität von Infektionen“) für die Autoren J. Harder und R. Gläser gefördert.

Einhaltung ethischer Richtlinien

Interessenkonflikt. J. Cordes, M. Wittersheim, J. Harder und R. Gläser geben an, dass kein Interessenkonflikt besteht. Dieser Beitrag beinhaltet keine Studien an Menschen oder Tieren.

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Authors and Affiliations

  1. Abteilung für Innere Medizin, Eduardus Krankenhaus Köln, Custodisstr. 3–17, 50679, Köln, Deutschland

    J. Cordes

  2. Institut für Pathologie, Universitätsklinikum Köln, Köln, Deutschland

    M. Wittersheim

  3. Klinik für Dermatologie, Venerologie und Allergologie, Universitätsklinikum Schleswig-Holstein, Campus Kiel, Kiel, Deutschland

    J. Harder & R. Gläser

Authors
  1. J. Cordes
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  2. M. Wittersheim
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  3. J. Harder
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  4. R. Gläser
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Corresponding author

Correspondence to J. Cordes.

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Cordes, J., Wittersheim, M., Harder, J. et al. Hauteigene Antibiotika. Hautarzt 65, 50–55 (2014). https://doi.org/10.1007/s00105-013-2638-6

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  • DOI: https://doi.org/10.1007/s00105-013-2638-6

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