Der Hautarzt

, Volume 64, Issue 10, pp 757–761

Off-label-Anwendung von Infliximab

Leitthema

Zusammenfassung

Der Tumornekrosefektor α (TNF) ist ein proinflammatorisches Zytokin und ein zentraler Entzündungsfaktor. Etliche TNFα-Antagonisten werden therapeutisch eingesetzt, darunter Infliximab, ein chimärer monoklonaler Antikörper mit Anti-TNFα-Aktivität. Zahlreiche Studien haben gezeigt, dass TNFα-Antagonisten in der Behandlung von Psoriasis – besonders bei schweren resistenten Formen – und Arthritis wirksam sind. Ferner wurden einige Kasuistiken und Studien zu TNFα bei neuen dermatologischen Indikationen publiziert. Ziel des Übersichtsartikels ist es, neue Off-label-Anwendungen von Infliximab anhand veröffentlichter Daten zusammenzufassen.

Schlüsselwörter

Tumornekrosefaktor α Antagonist Monoklonaler Antikörper Inflammation Zytokin 

Off-label use of infliximab

Abstract

Tumor necrosis factor α (TNFα) is a pro-inflammatory cytokine and a key mediator of inflammation. Several TNFα antagonists have been used therapeutically. One of them, infliximab, is a chimeric monoclonal antibody with anti-TNFα activity. Numerous studies have shown TNFα antagonists to be effective in treating psoriasis—particularly severe resistant forms—and arthritis. Additionally, several case reports and studies showing the effects of TNFα on new dermatologic indications have been published. The intention of this review is to summarize the new off-label uses of infliximab according to published data.

Keywords

Tumor necrosis factor α Antagonist Monoclonal antibody Inflammation Cytokine 

Supplementary material

105_2013_2596_MO1_ESM.pdf (474 kb)
Englische Version: Off-label-Anwendung von Infliximab (PDF475 KB)

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Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  1. 1.Hautärzte und Laserzentrum LandauDeutschland
  2. 2.Universität“Carol Davila” BukarestBukarestRumänien
  3. 3.Universität BernBernSchweiz
  4. 4.Universität OsnabrückOsnabrückDeutschland
  5. 5.Medizinische FakultätGazi Universität AnkaraAnkaraTürkei

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