Zusammenfassung
Nagelveränderungen sind häufig, aber oft nicht einfach einzuordnen. Grundlegende Kenntnisse der Anatomie und Biologie des Nagels erleichtern ihre Zuordnung. Vielfach lassen sich daraus die Entstehung und Morphologie zwanglos ableiten. Die folgende kurze Übersicht gibt Hinweise zu den wichtigsten Infektionen, entzündlichen Nagelkrankheiten und Tumoren.
Abstract
Nail alterations are frequently seen in daily practice, but they are often difficult to interpret. Basic knowledge of the anatomy and biology of the nail facilitates their diagnosis as this frequently allows their development and morphology to be explained. The following short review gives hints at the most important infections, inflammatory nail diseases and tumors.
Literatur
Sellheyer K, Nelson P (2012) The ventral proximal nail fold: stem cell niche of the nail and equivalent to the follicular bulge – a study on developing human skin. J Cutan Pathol 39:835–843
Theuns-Valks SD, Vergunst CE (2011) Een neonaat zonder nagels. Ned Tijdschr Geneeskd 155:A2747
Rambaud J, Marey I, Dupont C et al (2012) Nail and phalangeal agenesis in a patient with 4pter and 9pter duplication. Am J Med Genet A 158A:2277–2282
McGonagle D, Tan AL, Benjamin M (2009) The nail as a musculoskeletal appendage – implications for an improved understanding of the link between psoriasis and arthritis. Dermatology 218:97–102
Mir H, Khan S, Arif MS et al (2012) Mutations in the gene phospholipase C, delta-1 (PLCD1) underlying hereditary leukonychia. Eur J Dermatol [Epub ahead of print]
Boyce AE, McGrath JA, Techanukul T et al (2012) Ectodermal dysplasia-skin fragility syndrome due to a new homozygous internal deletion mutation in the PKP1 gene. Australas J Dermatol 53:61–65
Smith F (2003) The molecular genetics of keratin disorders. Am J Clin Dermatol 4:347–364
Lessard JC, Coulombe PA (2012) Keratin 16-null mice develop palmoplantar keratoderma, a hallmark feature of pachyonychia congenita and related disorders. J Invest Dermatol 132:1384–1391
Dhillon SS (2012) Yellow nail syndrome. Am J Respir Crit Care Med 186:e10
Tidder J, Pang CL (2012) A staged management of prolonged chylothorax in a patient with yellow nail syndrome. BMJ Case Rep. pii: bcr2012006469. doi:10.1136/bcr-2012-006469
Letheulle J, Deslée G, Guy T et al (2012) Le syndrome des ongles jaunes: presentation de cinq cas. Rev Mal Respir 29:419–425
Modrzewska K, Fijołek J, Ptak J, Wiatr E (2012) Yellow nail syndrome in a patient with membranous glomerulonephritis. Pneumonol Alergol Pol 80:158–162
Taki H, Tobe K (2012) Yellow nail syndrome associated with rheumatoid arthritis, thiol-compound therapy and early gastric cancer. BMJ Case Rep. pii: bcr1120115183. doi:10.1136/bcr.11.2011.5183
Haneke E (1991) Fungal infections of the nail. Semin Dermatol 10:41–53
Haneke E (1987) Nagelveränderungen bei Erkrankungen des Endokriniums. Therapiewoche 37:4379–4382
Alshawa K, Beretti JL, Lacroix C et al (2012) Successful identification of clinical dermatophyte and Neoscytalidium species by matrix-assisted laser desorption ionization-time of flight mass spectrometry. J Clin Microbiol 50:2277–2281
Luk NM, Hui M, Cheng TS et al (2012) Evaluation of PCR for the diagnosis of dermatophytes in nail specimens from patients with suspected onychomycosis. Clin Exp Dermatol 37:230–234
Haneke E (1985) Nail biopsies in onychomycosis. Mykosen 28: 473–480
Lawry M, Haneke E, Storbeck K et al (2000) Methods for diagnosing onychomycosis: a comparative study and review of the literature. Arch Dermatol 136:1112–1126
Baran R, Hay RJ, Tosti A, Haneke E (1998) A new classification of onychomycosis. Br J Dermatol 139:567–571
Haneke E, Djawari D (1982) Hyperimmunglobulin E-Syndrom: Atopisches Ekzem, Eosinophilie, Chemotaxisdefekt, Infektanfälligkeit und chronische mucocutane Candidose. Akt Dermatol 8:34–39
Puel A, Cypowyj S, Maródi L et al (2012) Inborn errors of human IL-17 immunity underlie chronic mucocutaneous candidiasis. Curr Opin Allergy Clin Immunol 12:616–622
Abeck D, Haneke E, Nolting S et al (2000) Onychomykose. Dtsch Ärztebl 97:A1984–A1986
Baran R, Feuilhade M, Combernale P et al (2000) A randomized trial of amorolfine 5 % solution nail lacquer combined with oral terbinafine compared with terbinafine alone in the treatment of dermatophytic toenail onychomycoses affecting the matrix region. Br J Dermatol 142:1177–1183
Scher RK, Tavakkol A, Sigurgeirsson B et al (2007) Onychomycosis: diagnosis and definition of cure. J Am Acad Dermatol 56:939–944
Zaias N, Tosti A, Rebell G et al (1996) Autosomal dominant pattern of distal subungual onychomycosis caused by Trichophyton rubrum. J Am Acad Dermatol 34:302–304
Haneke E (2011) Nail psoriasis. In: Soung J, Koo B (Hrsg) Psoriasis, Intech, Rijeka
Piraccini BM, Tosti A, Iorizzo M, Misciali C (2001) Pustular psoriasis of the nails: treatment and long-term follow-up of 46 patients. Br J Dermatol 144:1000–1005
Treewittayapoom C, Singvahanont P, Chanprapaph K, Haneke E (2012) The effect of different pulse durations in the treatment of nail psoriasis with 595-nm pulsed dye laser: a randomized, double-blind, intrapatient left-to-right study. J Am Acad Dermatol 66:807–812
Piraccini BM, Saccani E, Starace M et al (2010) Nail lichen planus: response to treatment and long term follow-up. Eur J Dermatol 20:489–496
Tosti A, Piraccini BM, Cambiaghi S, Jorizzo M (2001) Nail lichen planus in children: clinical features, response to treatment, and long-term follow-up. Arch Dermatol 137:1027–1032
Haneke E (2009) Non-infectious inflammatory disorders of the nail apparatus. J Dtsch Dermatol Ges 7:787–797
Haneke E (2012) Ungual melanoma – controversies in diagnosis and treatment. Dermatol Ther 25:510–524
North JP, Kageshita T, Pinkel D et al (2008) Distribution and significance of occult intraepidermal tumor cells surrounding primary melanoma. J Invest Dermatol 128:2024–2030
Haneke E, Binder D (1978) Subunguales Melanom mit streifiger Nagelpigmentierung. Hautarzt 29:389–391
Haneke E (1999) Operative Therapie akraler und subungualer Melanome. In: Rompel R, Petres J (Hrsg) Operative und onkologische Dermatologie. Fortschritte der operativen und onkologischen Dermatologie, Bd 15. Springer, Berlin, S 210–214
Möhrle M, Metzger S, Schippert W et al (2003) „Functional“ surgery in subungual melanoma. Dermatol Surg 29:366–374
Haneke E (2000) Maligne Nageltumoren. In: Koller J, Hintner H (Hrsg) Fortschritte der operativen und onkologischen Dermatologie, Bd 16. Blackwell Wissenschaftsverlag, Berlin, S 37–46
Choughri H, Villani F, Sawaya E, Pelissier P (2011) Atypical squamous cell carcinoma of the nail bed with phalangeal involvement. J Plast Surg Hand Surg 45:173–176
Interessenkonflikt
Der korrespondierende Autor weist auf folgende Beziehungen hin: Der Autor ist wissenschaftlicher Berater der Firmen Galderma und Pierre Fabre. Er hat keine Geschäftskontakte mit Firmen, deren Produkte hier genannt werden.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Haneke, E. Krankheiten der Nägel. Hautarzt 64, 519–532 (2013). https://doi.org/10.1007/s00105-013-2572-7
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00105-013-2572-7