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Krankheiten der Nägel

Diseases of the nails

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Zusammenfassung

Nagelveränderungen sind häufig, aber oft nicht einfach einzuordnen. Grundlegende Kenntnisse der Anatomie und Biologie des Nagels erleichtern ihre Zuordnung. Vielfach lassen sich daraus die Entstehung und Morphologie zwanglos ableiten. Die folgende kurze Übersicht gibt Hinweise zu den wichtigsten Infektionen, entzündlichen Nagelkrankheiten und Tumoren.

Abstract

Nail alterations are frequently seen in daily practice, but they are often difficult to interpret. Basic knowledge of the anatomy and biology of the nail facilitates their diagnosis as this frequently allows their development and morphology to be explained. The following short review gives hints at the most important infections, inflammatory nail diseases and tumors.

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Literatur

  1. Sellheyer K, Nelson P (2012) The ventral proximal nail fold: stem cell niche of the nail and equivalent to the follicular bulge – a study on developing human skin. J Cutan Pathol 39:835–843

    Article  PubMed  Google Scholar 

  2. Theuns-Valks SD, Vergunst CE (2011) Een neonaat zonder nagels. Ned Tijdschr Geneeskd 155:A2747

    PubMed  Google Scholar 

  3. Rambaud J, Marey I, Dupont C et al (2012) Nail and phalangeal agenesis in a patient with 4pter and 9pter duplication. Am J Med Genet A 158A:2277–2282

    Article  PubMed  Google Scholar 

  4. McGonagle D, Tan AL, Benjamin M (2009) The nail as a musculoskeletal appendage – implications for an improved understanding of the link between psoriasis and arthritis. Dermatology 218:97–102

    Article  PubMed  Google Scholar 

  5. Mir H, Khan S, Arif MS et al (2012) Mutations in the gene phospholipase C, delta-1 (PLCD1) underlying hereditary leukonychia. Eur J Dermatol [Epub ahead of print]

  6. Boyce AE, McGrath JA, Techanukul T et al (2012) Ectodermal dysplasia-skin fragility syndrome due to a new homozygous internal deletion mutation in the PKP1 gene. Australas J Dermatol 53:61–65

    Article  PubMed  Google Scholar 

  7. Smith F (2003) The molecular genetics of keratin disorders. Am J Clin Dermatol 4:347–364

    Article  PubMed  Google Scholar 

  8. Lessard JC, Coulombe PA (2012) Keratin 16-null mice develop palmoplantar keratoderma, a hallmark feature of pachyonychia congenita and related disorders. J Invest Dermatol 132:1384–1391

    Article  CAS  PubMed  Google Scholar 

  9. Dhillon SS (2012) Yellow nail syndrome. Am J Respir Crit Care Med 186:e10

    Article  PubMed  Google Scholar 

  10. Tidder J, Pang CL (2012) A staged management of prolonged chylothorax in a patient with yellow nail syndrome. BMJ Case Rep. pii: bcr2012006469. doi:10.1136/bcr-2012-006469

  11. Letheulle J, Deslée G, Guy T et al (2012) Le syndrome des ongles jaunes: presentation de cinq cas. Rev Mal Respir 29:419–425

    Article  CAS  PubMed  Google Scholar 

  12. Modrzewska K, Fijołek J, Ptak J, Wiatr E (2012) Yellow nail syndrome in a patient with membranous glomerulonephritis. Pneumonol Alergol Pol 80:158–162

    PubMed  Google Scholar 

  13. Taki H, Tobe K (2012) Yellow nail syndrome associated with rheumatoid arthritis, thiol-compound therapy and early gastric cancer. BMJ Case Rep. pii: bcr1120115183. doi:10.1136/bcr.11.2011.5183

  14. Haneke E (1991) Fungal infections of the nail. Semin Dermatol 10:41–53

    CAS  PubMed  Google Scholar 

  15.  Haneke E (1987) Nagelveränderungen bei Erkrankungen des Endokriniums. Therapiewoche 37:4379–4382

    Google Scholar 

  16. Alshawa K, Beretti JL, Lacroix C et al (2012) Successful identification of clinical dermatophyte and Neoscytalidium species by matrix-assisted laser desorption ionization-time of flight mass spectrometry. J Clin Microbiol 50:2277–2281

    Article  CAS  PubMed  Google Scholar 

  17. Luk NM, Hui M, Cheng TS et al (2012) Evaluation of PCR for the diagnosis of dermatophytes in nail specimens from patients with suspected onychomycosis. Clin Exp Dermatol 37:230–234

    Article  CAS  PubMed  Google Scholar 

  18. Haneke E (1985) Nail biopsies in onychomycosis. Mykosen 28: 473–480

    Article  CAS  PubMed  Google Scholar 

  19. Lawry M, Haneke E, Storbeck K et al (2000) Methods for diagnosing onychomycosis: a comparative study and review of the literature. Arch Dermatol 136:1112–1126

    Article  CAS  PubMed  Google Scholar 

  20.  Baran R, Hay RJ, Tosti A, Haneke E (1998) A new classification of onychomycosis. Br J Dermatol 139:567–571

    Article  CAS  PubMed  Google Scholar 

  21. Haneke E, Djawari D (1982) Hyperimmunglobulin E-Syndrom: Atopisches Ekzem, Eosinophilie, Chemotaxisdefekt, Infektanfälligkeit und chronische mucocutane Candidose. Akt Dermatol 8:34–39

    Google Scholar 

  22. Puel A, Cypowyj S, Maródi L et al (2012) Inborn errors of human IL-17 immunity underlie chronic mucocutaneous candidiasis. Curr Opin Allergy Clin Immunol 12:616–622

    Article  CAS  PubMed  Google Scholar 

  23. Abeck D, Haneke E, Nolting S et al (2000) Onychomykose. Dtsch Ärztebl 97:A1984–A1986

    Google Scholar 

  24. Baran R, Feuilhade M, Combernale P et al (2000) A randomized trial of amorolfine 5 % solution nail lacquer combined with oral terbinafine compared with terbinafine alone in the treatment of dermatophytic toenail onychomycoses affecting the matrix region. Br J Dermatol 142:1177–1183

    Article  CAS  PubMed  Google Scholar 

  25. Scher RK, Tavakkol A, Sigurgeirsson B et al (2007) Onychomycosis: diagnosis and definition of cure. J Am Acad Dermatol 56:939–944

    Article  PubMed  Google Scholar 

  26. Zaias N, Tosti A, Rebell G et al (1996) Autosomal dominant pattern of distal subungual onychomycosis caused by Trichophyton rubrum. J Am Acad Dermatol 34:302–304

    Article  CAS  PubMed  Google Scholar 

  27. Haneke E (2011) Nail psoriasis. In: Soung J, Koo B (Hrsg) Psoriasis, Intech, Rijeka

  28. Piraccini BM, Tosti A, Iorizzo M, Misciali C (2001) Pustular psoriasis of the nails: treatment and long-term follow-up of 46 patients. Br J Dermatol 144:1000–1005

    Article  CAS  PubMed  Google Scholar 

  29. Treewittayapoom C, Singvahanont P, Chanprapaph K, Haneke E (2012) The effect of different pulse durations in the treatment of nail psoriasis with 595-nm pulsed dye laser: a randomized, double-blind, intrapatient left-to-right study. J Am Acad Dermatol 66:807–812

    Article  PubMed  Google Scholar 

  30. Piraccini BM, Saccani E, Starace M et al (2010) Nail lichen planus: response to treatment and long term follow-up. Eur J Dermatol 20:489–496

    PubMed  Google Scholar 

  31. Tosti A, Piraccini BM, Cambiaghi S, Jorizzo M (2001) Nail lichen planus in children: clinical features, response to treatment, and long-term follow-up. Arch Dermatol 137:1027–1032

    CAS  PubMed  Google Scholar 

  32. Haneke E (2009) Non-infectious inflammatory disorders of the nail apparatus. J Dtsch Dermatol Ges 7:787–797

    PubMed  Google Scholar 

  33. Haneke E (2012) Ungual melanoma – controversies in diagnosis and treatment. Dermatol Ther 25:510–524

    Article  PubMed  Google Scholar 

  34. North JP, Kageshita T, Pinkel D et al (2008) Distribution and significance of occult intraepidermal tumor cells surrounding primary melanoma. J Invest Dermatol 128:2024–2030

    Article  CAS  PubMed  Google Scholar 

  35. Haneke E, Binder D (1978) Subunguales Melanom mit streifiger Nagelpigmentierung. Hautarzt 29:389–391

    CAS  PubMed  Google Scholar 

  36. Haneke E (1999) Operative Therapie akraler und subungualer Melanome. In: Rompel R, Petres J (Hrsg) Operative und onkologische Dermatologie. Fortschritte der operativen und onkologischen Dermatologie, Bd 15. Springer, Berlin, S 210–214

  37. Möhrle M, Metzger S, Schippert W et al (2003) „Functional“ surgery in subungual melanoma. Dermatol Surg 29:366–374

    Article  Google Scholar 

  38. Haneke E (2000) Maligne Nageltumoren. In: Koller J, Hintner H (Hrsg) Fortschritte der operativen und onkologischen Dermatologie, Bd 16. Blackwell Wissenschaftsverlag, Berlin, S 37–46

  39. Choughri H, Villani F, Sawaya E, Pelissier P (2011) Atypical squamous cell carcinoma of the nail bed with phalangeal involvement. J Plast Surg Hand Surg 45:173–176

    Article  PubMed  Google Scholar 

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Interessenkonflikt

Der korrespondierende Autor weist auf folgende Beziehungen hin: Der Autor ist wissenschaftlicher Berater der Firmen Galderma und Pierre Fabre. Er hat keine Geschäftskontakte mit Firmen, deren Produkte hier genannt werden.

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Haneke, E. Krankheiten der Nägel. Hautarzt 64, 519–532 (2013). https://doi.org/10.1007/s00105-013-2572-7

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