Zusammenfassung
Chronische UV-Exposition ist der wichtigste ätiologische Faktor bei der Entstehung von malignen Hauttumoren. Besonders gefährdet sind hellhäutige Menschen, die berufsbedingt oder in ihrer Freizeit länger und ohne Sonnenschutz dem Sonnenlicht ausgesetzt sind. Im Folgenden wird eine Zusammenfassung über die Histopathologie von UV-Licht-bedingten malignen kutanen Tumoren gegeben.
Abstract
Chronic exposure to UV light is the most important etiological factor for the occurrence of malignant skin tumors. Light-skinned persons who for professional reasons or in leisure activities are exposed to sunlight without sun protection for long periods of time are particularly at risk. This article gives a summary of the histopathology of malignant skin tumors caused by UV light.
Literatur
Armstrong BK, Kricker A (2001) The epidemiology of UV induced skin cancer. J Photochem Photobiol B 63(1–3):8–18
Ackermann AB, Jacobson M, Vitale P (1990) Clues to diagnosis in dermatopathology. ASCP, Chicago
Breslow A (1970) Thickness, cross-sectional areas and depth of invasion in the prognosis of cutaneous melanoma. Ann Surg 172:902–908
Busam KJ (2005) Cutaneous desmoplastic melanoma. Adv Anat Pathol 12:92–102
Buzaid AC, Anderson CM (2000) The changing prognosis of melanoma. Curr Oncol Rep 2:322–328
Clark WH Jr et al (1969) The histogenesis and biologic behavior of primary human malignant melanomas of the skin. Cancer Res 29:705–727
Conley J, Lattes R, Orr W (1971) Desmoplastic malignant melanoma (a rare variant of spindle cell melanoma). Cancer 28:914–936
Coory M, Baade P, Aitken J et al (2006) Trends for in situ and invasive melanoma in Queensland, Australia, 1982–2002. Cancer Causes Control 17(1):21–27
Diagnosis and treatment of melanoma. European consensus-based interdisciplinary guideline. www.euroderm.org/index.php/edf-guidelines
Garbe C (2008) Early detection and primary prevention of skin cancer. Onkologe 14(2):156–163
Garbe C, Blum A (2001) Epidemiology of cutaneous melanoma in Germany and worldwide. Skin Pharmacol Appl Skin Physiol 14(5):280–290
Gardner WA Jr, Vazquez MD (1970) Balloon cell melanoma. Arch Pathol 89:470–472
Glogau R (2000) The risk of progression to invasive disease. J Am Acad Dermatol 42:23–24
Keefe M, MacKie RM (1991) The relationship between risk of death from clinical stage 1 cutaneous melanoma and thickness of primary tumour: no evidence for steps in risk. Scottish Melanoma Group. Br J Cancer 64:598–602
Kerl H et al (2003) Histopathologie der Haut. Springer, Berlin Heidelberg
Lasithiotakis KG, Leiter U, Gorkievicz R et al (2006) The incidence and mortality of cutaneous melanoma in Southern Germany: trends by anatomic site and pathologic characteristics, 1976–2003. Cancer 107(6):1331–1339
Leitlinie: aktinische Keratose. http://www.derma.de/…/Leitlinien/leitlinie_aktinische_keratose_ado_2005
Leitlinie: Basaliom. http://www.krebsgesellschaft.de/download/leitlinie_basaliom_ado_2005.pdf
Leitlinie: Plattenepithelkarzinom. http://www.krebsgesellschaft.de/download/leitlinie_spinaliom_ado_2005.pdf
MacKie RM (2000) Malignant melanoma: clinical variants and prognostic indicators. Clin Exp Dermatol 25:471–475
Maize JC, Ackerman BA (1987) Pigmented lesions of the skin. Lea&Febiger, Philadelphia
Markovic SN, Erickson LA, Rao RD et al (2007) Malignant melanoma in the 21st century, part 1: epidemiology, risk factors, screening, prevention, and diagnosis. Mayo Clin Proc 82(3):364–380
Massi G, LeBoit PE (2005) Histological diagnosis of nevi and melanoma. Steinkopff, Darmstadt
McCarthy SW, Scolyer RA, Palmer AA (2004) Desmoplastic melanoma: a diagnostic trap for the unwary. Pathology 36:445–451
McKee PH, Calonje E, Granter SR (2005) Pathology of the skin with clinical correlations, 3. Aufl. Elsevier Mosby
Megahed M (1999) Polypoid basal cell carcinoma: a new clinicopathological variant. Br J Dermatol 140:701–703
Megahed M (2006) Histopathologie des malignen Melanom. In: Hengge UR, Dummer R (Hrsg) Malignes Melanom. Standards und Innovationen in Diagnostik und Therapie. Deutscher Ärzte Verlag, Köln
Megahed M et al (2002) Reliability of diagnosis of melanoma in situ. Lancet 359:1921–1922
Megahed M et al (1994) Amelanotic polypoid malignant melanoma of the ballon cell type. Pathologe 15:350–353
Megahed M et al (1993) Polypoid malignant melanoma. An aggressive, seldom observed variant of nodular malignant melanoma. Hautarzt 44:437–439
Narayanan DL, Saladi RN, Fox JL (2010) Ultraviolet radiation and skin cancer. Int J Dermatol 49(9):978–986
Salasche SJ (2000) Epidemiology of actinic keratoses and squamous cell carcinoma. J Am Acad Dermatol 42:4–7
Schmoeckel C, Castro CE, Braun-Falco O (1985) Nevoid malignant melanoma. Arch Dermatol Res 277:362–369
Vogler WR, Perdue GD, Wilkins SA Jr (1958) A clinical evaluation of malignant melanoma. Surg Gynecol Obstet 106:586–594
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Megahed, M. Histologie UV-Licht-bedingter maligner Hauttumore. Hautarzt 63, 778–787 (2012). https://doi.org/10.1007/s00105-012-2401-4
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DOI: https://doi.org/10.1007/s00105-012-2401-4