Literatur
Chapman PB, Hauschild A, Robert C et al (2011) Improved survival with vemurafenib in melanoma with BRAF V600E mutation. N Engl J Med 364:2507–2516
Davies H, Bignell GR, Cox C et al (2002) Mutations of the BRAF gene in human cancer. Nature 417:949–954
Curtin JA, Fridlyand J, Kageshita T et al (2005) Distinct sets of genetic alterations in melanoma. N Engl J Med 353:2135–2147
Landi MT, Bauer J, Pfeiffer RM et al (2006) MC1R germline variants confer risk for BRAF-mutant melanoma. Science 313:521–522
Pollock PM, Harper UL, Hansen KS et al (2003) High frequency of BRAF mutations in nevi. Nat Genet 33:19–20
Michaloglou C, Vredeveld LC, Soengas MS et al (2005) BRAFE600-associated senescence-like cell cycle arrest of human naevi. Nature 436:720–724
Dankort D, Curley DP, Cartlidge RA et al (2009) Braf (V600E) cooperates with Pten loss to induce metastatic melanoma. Nat Genet 41:544–552
Flaherty KT, Puzanov I, Kim KB et al (2010) Inhibition of mutated, activated BRAF in metastatic melanoma. N Engl J Med 363:809–819
Hatzivassiliou G, Song K, Yen I et al (2010) RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth. Nature 464:431–435
Poulikakos PI, Zhang C, Bollag G et al (2010) RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF. Nature 464:427–430
Heidorn SJ, Milagre C, Whittaker S et al (2010) Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF. Cell 140:209–221
Johannessen CM, Boehm JS, Kim SY et al (2010) COT drives resistance to RAF inhibition through MAP kinase pathway reactivation. Nature 468:968–972
Nazarian R, Shi H, Wang Q et al (2010) Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation. Nature 468:973–977
Interessenkonflikt
Der korrespondierende Autor weist auf folgende Beziehung hin: Der Autor erhielt von der Firma Roche und Bristol-Myers Squibb Honorare.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Hafner, C. Therapie des metastasierten Melanoms mit BRAF-Inhibitoren. Hautarzt 62, 696–698 (2011). https://doi.org/10.1007/s00105-011-2232-8
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00105-011-2232-8