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Neuropeptide und ihre Rezeptoren als molekulare Grundlage der empfindlichen Haut

Neuropeptides and their receptors as a molecular explanation for sensitive skin

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Zusammenfassung

Die sog. empfindliche Haut (engl. „sensitive skin“) ist vermutlich eher ein Symptom, bestehend aus verschiedenen physiologischen Reaktionen, als eine eigene Entität. Gemäß epidemiologischen Studien leiden bis zu 50% aller Erwachsenen an verschiedenen Symptomen empfindlicher Gesichtshaut wie Kribbeln, Brennen, Prickeln, Schmerzen oder Pruritus. Diese Sensationen können von Rezeptoren, die auf Nervenfasern und auch in Keratinozyten exprimiert sind, vermittelt werden. Zum Beispiel ist der Wärmerezeptor TRPV1 an der kutanen Nozizeption beteiligt und kann bei Hitzeempfinden auch ein Brenngefühl vermitteln. Des Weiteren können Neurotrophine und exogene Einflussfaktoren wie Stress eine biologische Bedeutung haben, was in diesem Übersichtsbeitrag diskutiert wird.

Abstract

The concept of sensitive skin represents a symptom of physiological reactions rather than a disease entity. According to epidemiological studies, up to 50% of adults report on sensitivity of the face with various distinctive symptoms such as prickling, burning, tingling, pain or itching. These sensations can be mediated by receptors expressed on neurons and keratinocytes. The heat receptor TRPV1 is for example involved in nociception and mediates not only warmth but also burning. Furthermore, neurotrophins and exogenic factors such as stress may have a biological role as discussed in this review.

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  1. Abteilung für Zellphysiologie, Ruhr Universität Bochum, Bochum, Deutschland

    H. Benecke & H. Hatt

  2. Klinik für Dermatologie, Universitätsklinikum Mannheim der Universität Heidelberg, Heidelberg, Deutschland

    S. W. Schneider

  3. Klinik und Poliklinik für Hautkrankheiten, Kompetenzzentrum Chronischer Pruritus (KCP), Universitätsklinikum Münster, Von-Esmarch-Str. 58, 48149, Münster, Deutschland

    T. Lotts, T. A. Luger &  S. Ständer

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Benecke, H., Schneider, S., Lotts, T. et al. Neuropeptide und ihre Rezeptoren als molekulare Grundlage der empfindlichen Haut. Hautarzt 62, 893–899 (2011). https://doi.org/10.1007/s00105-011-2208-8

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