Zusammenfassung
Morbus Hailey-Hailey ist eine seltene hereditäre Erkrankung mit einem autosomal-dominanten Erbgang. Wir präsentieren den Fall einer 56-jährigen Patientin, die sich mit einem seit 15 Jahren bestehenden, chronisch rezidivierenden und therapieresistenten M. Hailey-Hailey in unserer Klinik vorstellte. Aufgrund des frustranen Verlaufs unter konservativen Therapiemaßnahmen führten wir eine ablative CO2-Laserbehandlung der Hautläsionen in Intubationsnarkose durch. Im Rahmen der klinischen Kontrollen nach 6 Wochen und nach einem halben Jahr zeigte sich eine komplette und anhaltende Remission der Hautveränderungen in den behandelten Arealen. Nach unseren Erfahrungen stellt die Ablation mittels CO2-Laser eine effektive und nebenwirkungsarme Option bei der Behandlung eines therapieresistenten M. Hailey-Hailey dar.
Abstract
Hailey-Hailey disease is a rare, autosomal dominantly inherited genodermatosis, which manifests with recurrent intraepidermal blistering and erythematous hyperkeratotic patches in intertriginous areas. Conventional therapeutic approaches include topical and systemic steroids, antibiotic agents, as well as oral retinoids. Alternative treatments include surgical interventions such as excision, dermabrasion and laser ablation. A 56-year-old woman presented with 15-year history of severe therapy-resistant Hailey-Hailey disease. We performed laser ablation with carbon dioxide laser under general anesthesia. Six weeks after treatment complete remission within ablated areas was achieved. Six-month follow-up showed no relapse. In our opinion carbon dioxide laser ablation represents an effective and safe therapeutic option for Hailey-Hailey disease.
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Kukova, G., Homey, B., Bruch-Gerharz, D. et al. Pemphigus chronicus benignus familiaris (Morbus Hailey-Hailey). Hautarzt 62, 258–261 (2011). https://doi.org/10.1007/s00105-011-2151-8
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DOI: https://doi.org/10.1007/s00105-011-2151-8