Zusammenfassung
Vitamin-D-Mangel ist eine Endemie, von der weltweit schätzungsweise mehr als 1 Milliarde Menschen betroffen sind und an der in Deutschland ca. 60% der Bevölkerung leiden. In den letzten Jahren hat sich unser Verständnis über die wichtige Bedeutung des Vitamin-D-Stoffwechsels für den menschlichen Organismus entscheidend erweitert. Neben epidemiologischen Untersuchungen konnten In-vitro-Untersuchungen und Untersuchungen an Tiermodellen wichtige neue Funktionen von Vitamin D belegen, darunter auch potente immunmodulatorische und wachstumsregulierende Eigenschaften. Wir wissen daher heute, dass Vitamin-D-Mangel nicht nur mit einem erhöhten Risiko für Erkrankungen des Knochen- und Kalziumstoffwechsels, sondern auch mit einem erhöhten Risiko für zahlreiche weitere Erkrankungen (u. a. verschiedene Krebserkrankungen, kardiovaskuläre Erkrankungen, Infektionserkrankungen, Autoimmunerkrankungen) assoziiert ist. In diesem Beitrag wird der aktuelle Wissensstand zur Bedeutung des Vitamin-D-Stoffwechsels in der humanen Haut erörtert.
Abstract
Vitamin D deficiency is endemic, affecting worldwide approximately more than 1 billion people and approximately 60% of the German population. In recent years, our understanding of the important role of vitamin D for human health has grown enormously. Epidemiological and in vitro investigations as well as animal studies have convincingly demonstrated new important functions of vitamin D, including potent immunoregulatory and growth regulatory properties. We know today that vitamin D deficiency/insufficiency is not exclusively associated with an increased risk for bone diseases, but with a multitude of other diseases (including various types of cancer, cardiovascular diseases, infectious diseases, and autoimmune diseases). We discuss our present understanding of the importance of the cutaneous vitamin D system.
Abbreviations
- AMP:
-
antimikrobielles Peptid
- 7-DHC:
-
7-Dehydrocholesterol
- IFN-γ:
-
Interferon γ
- 1,25(OH)2D:
-
1,25-Dihydroxyvitamin D3, Calcitriol
- TNF-α:
-
Tumornekrosefaktor α
- VDR:
-
Vitamin-D-Rezeptor
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Der korrespondierende Autor weist auf folgende Beziehung hin: J.R. Rednerhonorar von Fa. Diasorin.
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Trémezaygues, L., Reichrath, J. Zur Bedeutung des Vitamin-D-Stoffwechsels in der humanen Haut. Hautarzt 61, 478–486 (2010). https://doi.org/10.1007/s00105-009-1893-z
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DOI: https://doi.org/10.1007/s00105-009-1893-z