Zusammenfassung
Die weizenabhängige anstrengungsinduzierten Anaphylaxie (WDEIA) ist eine IgE-vermittelte anaphylaktische Reaktion gegenüber Weizen, die bei Sensibilisierten nach Verzehr von weizenmehlhaltigen Produkten auftritt, wenn der Nahrungsaufnahme körperliche Anstrengung folgt. Als Hauptallergen wurde das Weizenprotein Omega(ω)-5-Gliadin (Tri a 19) identifiziert. Wir präsentieren 3 Fallberichte von Patienten, bei denen die Diagnose einer WDEIA durch den Nachweis von spezifischem IgE gegen das rekombinante Protein Tri a 19 gesichert werden konnte.
Abstract
Wheat-dependent exercise-induced anaphylaxis (WDEIA) is a rare IgE-dependent anaphylaxis to wheat, which occurs in sensitized people after ingestion of wheat followed by physical exercise. The major allergen associated with WDEIA is the wheat protein Omega (ω)-5-Gliadin (Tri a 19). We present three cases of WDEIA, demonstrating that this disease might be more frequent than anticipated and that neither prick test nor specific IgE to allergen extracts but rather detection of specific IgE against the recombinant protein Tri a 19 leads to diagnosis.
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Literatur
Benhamou AH, Vanini G, Lantin JP, Eigenmann PA (2007) Antihistamine and sodium cromoglycate medication for food cold water exercise-induced anaphylaxis. Allergy 62(12):1471–1472
Erdmann SM, Sachs B, Schmidt A et al (2005) In vitro analysis of birch-pollen-associated food allergy by use of recombinant allergens in the basophil activation test. Int Arch Allergy Immunol 136(3):230–238
Herzinger T, Kick G, Ludolph-Hauser D, Przybilla B (2004) Anaphylaxis to wheat beer. Ann Allergy Asthma Immunol 92(6):673–675
Inomata N (2009) Wheat allergy. Curr Opin Allergy Clin Immunol 9(3):238–243
Ito K, Futamura M, Borres MP (2008) IgE antibodies to omega-5 gliadin associate with immediate symptoms on oral wheat challenge in Japanese children. Allergy 63(11):1536–1542
Matsuo H, Morimoto K, Akaki T et al (2005) Exercise and aspirin increase levels of circulating gliadin peptides in patients with wheat-dependent exercise-induced anaphylaxis. Clin Exp Allergy 35(4):461–466
Matsuo H, Matsuo H, Kohno K et al (2005) Specific IgE determination to epitope peptides of omega-5 gliadin and high molecular weight glutenin subunit is a useful tool for diagnosis of wheat-dependent exercise-induced anaphylaxis. J Immunol 175(12):8116–8122
Matsuo H, Dahlstrom J, Tanaka A et al (2008) Sensitivity and specificity of recombinant omega-5 gliadin-specific IgE measurement for the diagnosis of wheat-dependent exercise-induced anaphylaxis. Allergy 63(2):233–236
Morita E, Kunie K, Matsuo H (2007) Food-dependent exercise-induced anaphylaxis. J Dermatol Sci 47(2):109–117
Palosuo K, Varjonen E, Nurkkala J et al (2003) Transglutaminase-mediated cross-linking of a peptic fraction of omega-5 gliadin enhances IgE reactivity in wheat-dependent, exercise-induced anaphylaxis. J Allergy Clin Immunol 111(6):1386–1392
Ring J, Messmer K (1977) Incidence and severity of anaphylactoid reactions to colloid volume substitutes. Lancet 1(8009):466–469
Tatham AS, Shewry PR (2008) Allergens to wheat and related cereals. Clin Exp Allergy 38(11):1712–1726
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Brans, R., Ott, H. & Merk, H. Weizenabhängige anstrengungsinduzierte Anaphylaxie. Hautarzt 60, 956–960 (2009). https://doi.org/10.1007/s00105-009-1875-1
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DOI: https://doi.org/10.1007/s00105-009-1875-1