Skip to main content
Log in

Mundschleimhaut als Spiegel systemischer Erkrankungen

Oral manifestations of systemic diseases

  • Leitthema
  • Published:
Der Hautarzt Aims and scope Submit manuscript

Zusammenfassung

Viele Systemerkrankungen können sich an der Mundschleimhaut als zielführender „Nebenbefund“ zeigen und mitunter auf eine noch latente Grunderkrankung hinweisen. Geordnet nach Organsystemen sollen hier häufige spezifische und unspezifische und seltenere, aber besonders prägnante orale Veränderungen innerer Erkrankungen aufgezeigt werden. Die häufigsten Mundschleimhautbefunde im Rahmen der HIV-Infektion und die kennzeichnenden mukokutanen Markerläsionen verschiedener Genodermatosen werden erläutert.

Abstract

Many systemic diseases may present with oral manifestations and the oral mucosa may act as a mirror of internal involvement. We discuss the most common, specific and unspecific, as the most peculiar oral mucosal manifestations of systemic disease in the different organ systems. The most prevalent conditions of the oral mucosa in the course of HIV infection and marker lesions of multisystemic genodermatoses are elucidated.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Abb. 1
Abb. 2
Abb. 3
Abb. 4
Abb. 5
Abb. 6

Literatur

  1. Antoniades DZ, Markopoulos AK, Andreadis D et al (2006) Ulcerative uremic stomatitis associated with untreated chronic renal failure: report of a case and review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 101:608–613

    Article  PubMed  Google Scholar 

  2. Daley TD, Armstrong JE (2007) Oral manifestations of gastrointestinal diseases. Can J Gastroenterol 21:241–244

    PubMed  Google Scholar 

  3. Femiano F, Lanza A, Buonaiuto C et al (2009) Pyostomatitis vegetans: a review of the literature. Med Oral Pathol Oral Cir Bucal 14:E114–E117

    Google Scholar 

  4. Fistarol SK, Anliker MD, Itin PH (2002) Cowden disease or multiple hamartoma syndrome – cutaneous clue to internal malignancy. Eur J Dermatol 12:411–421

    PubMed  Google Scholar 

  5. Greenspan D, Canchola AJ, MacPhail LA et al (2001) Effect of highly active antiretroviral therapy on frequency of oral warts. Lancet 357:1411–1412

    Article  CAS  PubMed  Google Scholar 

  6. Guggenheimer J, Moore PA, Rossie K et al (2000) Insulin-dependent diabetes mellitus and oral soft tissue pathologies. I. Prevalence and characteristics of non-candidal lesions. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 89:563–569

    Article  CAS  PubMed  Google Scholar 

  7. Guggenheimer J, Moore PA, Rossie K et al (2000) Insulin-dependent diabetes mellitus and oral soft tissue pathologies. II. Prevalence and characteristics of Candida and candidal lesions. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 89:570–576

    Article  CAS  PubMed  Google Scholar 

  8. Hand JL, Rogers RS III (2003) Oral manifestations of genodermatoses. Dermatol Clin 21:183–194

    PubMed  Google Scholar 

  9. Harty S, Fleming P, Rowland M et al (2005) A prospective study of the oral manifestations of Crohn’s disease. Clin Gastroenterol Hepatol 3:886–891

    Article  PubMed  Google Scholar 

  10. Hirshberg A, Shnaiderman-Shapiro A, Kaplan I, Berger R (2008) Metastatic tumours to the oral cavity – pathogenesis and analysis of 673 cases. Oral Oncol 44:743–752

    Article  PubMed  Google Scholar 

  11. Itin PH, Lautenschlager S, Flückiger R, Rufli T (1993) Oral manifestations in HIV-infected patients: diagnosis and management. J Am Acad Dermatol 29:749–760

    Article  CAS  PubMed  Google Scholar 

  12. Kemp S, Gallagher G, Kabani S et al (2008) Oral non-Hodgkin’s lymphoma: review of the literature and World Health Organization classification with reference to 40 cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 105:194–201

    Article  PubMed  Google Scholar 

  13. Leâo J, Gueiros LAM, Segundo AVL et al (2005) Uremic stomatitis in chronic renal failure. Clinics 60:259–262

    Article  PubMed  Google Scholar 

  14. MacNeal RJ, Dinulos JG (2006) Acute retroviral syndrome. Dermatol Clin 24:431–438

    Article  CAS  PubMed  Google Scholar 

  15. Madrigal-Martínez-Pereda C, Guerrero-Rodríguez V, Guisado-Moya B, Meniz-García C (2009) Langerhans cell histiocytosis: literature review and descriptive analysis of oral manifestations. Med Oral Patol Oral Cir Bucal 14:E222–E228

    PubMed  Google Scholar 

  16. Malahias T, Cheng J, Brar P et al (2009) The association between celiac disease, dental enamel defects, and aphthous ulcers in a United States Cohort. J Clin Gastroenterol (Epub ahead of print)

  17. Nico MMS, Vilela MAC, Rivitti EA, Laurenço SV (2008) Oral lesions in lupus erythematodes: correlation with cutaneous lesions. Eur J Dermatol 18:376–381

    PubMed  Google Scholar 

  18. Pastore L, Carroccio A, Compilato D et al (2008) Oral manifestations of celiac disease. J Clin Gastroenterol 42:224–232

    Article  PubMed  Google Scholar 

  19. Patten SF, Tomecki KJ (1993) Wegener’s granulomatosis: cutaneous and oral mucosal disease. J Am Acad Dermatol 28:710–718

    Article  CAS  PubMed  Google Scholar 

  20. Reznik DA (2005) Oral manifestations of HIV disease. Top HIV Med 13:143–148

    PubMed  Google Scholar 

  21. Ship JA (2003) Diabetes and oral health: an overview. J Am Dent Assoc 134:4S–10S

    PubMed  Google Scholar 

  22. Stewart C, Cohen D, Bhattacharyya I et al (2007) Oral manifestations of Wegener’s granulomatosis: a report of three cases and a literature review. J Am Dent Assoc 138:338–348

    PubMed  Google Scholar 

  23. Suresh L, Radfar L (2005) Oral sarcoidosis: a review of the literature. Oral Dis 11:138–145

    CAS  PubMed  Google Scholar 

  24. van der Waal RIF, Huijgens PC, van der Valk P, van der Waal I (2005) Characteristics of 40 primary extranodal non-Hodgkin lymphomas of the oral cavity in perspective of the new WHO classification and the International Prognostic Index. Int J Oral Maxillofac Surg 34:391–395

    Article  Google Scholar 

  25. Vincent C, Agard C, Barbarot S et al (2009) Orofacial manifestations of systemic sclerosis: a study of 30 consecutive patients. Rev Med Interne 30:5–11

    Article  CAS  PubMed  Google Scholar 

  26. Vitali C, Bombardieri S, Jonsson R et al (2002) European Study Group on Classification Criteria for Sjogren’s Syndrome. Classification criteria for Sjögren’s syndrome: a revised version of the European criteria proposed by the American-European Consensus Group. Ann Rheum Dis 61:554–558

    Article  CAS  PubMed  Google Scholar 

Download references

Interessenkonflikt

Der korrespondierende Autor gibt an, dass kein Interessenkonflikt besteht.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to S.K. Fistarol.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Fistarol, S., Itin, P. Mundschleimhaut als Spiegel systemischer Erkrankungen. Hautarzt 60, 866–877 (2009). https://doi.org/10.1007/s00105-009-1802-5

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00105-009-1802-5

Schlüsselwörter

Keywords

Navigation