Zusammenfassung
Ein 67-jähriger Patient entwickelte innerhalb kurzer Zeit mehrere hautfarbene Knoten an seinem linken Handrücken. Das histologische Gutachten ergab ein Merkel-Zell-Karzinom (MCC). Das MCC ist ein äußerst aggressiv wachsender kutaner Tumor, der von neuroendokrinen Zellen der Basalschicht der Epidermis ausgeht. Bekannte Risikofaktoren sind ein fortgeschrittenes Alter, Immunsuppression und UV-Exposition. Aktuelle Studien konnten ein neues Polyomavirus (MCPyV) in 75–85% der Neoplasien nachweisen, das eine zentrale Rolle in der Entstehung des MCC zu spielen scheint. Hier erhofft man sich neue und wirksamere Therapieoptionen.
Abstract
A 67-year old patient developed multiple flesh-colored nodules on the back of his left hand. Histological examination led to the diagnosis of a Merkel cell carcinoma (MCC). This highly aggressive primary cutaneous tumor is classified as a neuroendocrine carcinoma. It affects mostly elderly and immunosuppressed patients. Recently, a new polyomavirus (MCPyV) has been detected in about 75–85% of MCC and seems to play an important role in their pathogenesis. This new finding may help to develop new therapeutic options for MCC.
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Wosnitza, M., Bozkurt, A., O’Dey, D. et al. Merkel-Zell-Karzinom des Handrückens. Hautarzt 60, 366–368 (2009). https://doi.org/10.1007/s00105-009-1748-7
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DOI: https://doi.org/10.1007/s00105-009-1748-7