Zusammenfassung
Die Assoziation einer linearen IgA-Dermatose, Colitis ulcerosa und vernarbender Augenbeteiligung ist sehr selten und bleibt eine therapeutische Herausforderung. Wir beschreiben einen 48-jährigen Patienten mit einer 1995 diagnostizierten Colitis ulcerosa, die mittels Methylprednisolon behandelt wurde. Im Verlauf entwickelte er rezidivierende Konjunktivitiden mit Vernarbungen und Synechien sowie Schübe von vesikulösen Hautveränderungen. Auch unter Azathioprin kam es zu keiner kompletten Abheilung. Nach Diagnosestellung einer linearen IgA-Dermatose wurde eine zusätzliche Dapsontherapie eingeleitet. Hierunter besserten sich sowohl der Augen- als auch der Hautbefund signifikant, sodass Methylprednisolon langsam ausgeschlichen werden konnte.
Abstract
The association of linear IgA disease (LAD), ulcerative colitis and scarring ocular involvement is very rare and represents a considerable therapeutic challenge. We report a 48-year-old male diagnosed with ulcerative colitis in 1995, who received long-term methylprednisolone therapy. Later, he developed ocular inflammation with conjunctival scarring and synechiae formation as well as episodes of vesicles. Although azathioprine was added to his regimen, the disease was not controlled. After the diagnosis of LAD was established, dapsone was added. With this therapy, the ocular inflammation decreased significantly and the methylprednisolone dose could be successfully tapered slowly without reappearance of vesicles.
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Klein, A., Wenzel, S., Messmer, E. et al. Lineare IgA-Dermatose mit Augenbeteiligung in Assoziation mit Colitis ulcerosa. Hautarzt 61, 55–57 (2010). https://doi.org/10.1007/s00105-009-1737-x
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DOI: https://doi.org/10.1007/s00105-009-1737-x