Skip to main content
SpringerLink
Log in

Management der Acne vulgaris: Fokus auf Clindamycin und Zink

Management of acne vulgaris: Focus on clindamycin and zinc

  • Übersichten
  • Published:
Der Hautarzt Aims and scope Submit manuscript

Zusammenfassung

In der Behandlung der leichten bis mittelschweren Akne hat sich die topische Therapie mit Antibiotika, insbesondere mit Clindamycin, bewährt. Kombinationen aus Clindamycin und Begleitsubstanzen wie Benzoylperoxid, Retinoiden oder Zink sind im Hinblick auf ihre Effektivität und Verträglichkeit der Clindamycin-Monotherapie womöglich überlegen, wobei die Evidenz für die Kombination aus 1% Clindamycin und 5% Benzoylperoxid besonders gut ist. Eine aktuelle Untersuchung belegt darüber hinaus die besonders hohe Patientenakzeptanz eines Komplexes aus Zinkacetat und Clindamycinphosphat.

Abstract

Topical antibiotics, especially clindamycin, are well-accepted in the treatment of mild to moderate acne. Combinations of clindamycin and other agents such as benzoyl peroxide, retinoids or zinc, are possibly superior to clindamycin monotherapy regarding efficacy and tolerability with the combination 1% clindamycin/5% benzoyl peroxide being particularly well-supported by evidence. Moreover, a recent study has shown that patients themselves prefer a complex of zinc acetate/clindamycin phosphate.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Abb. 1
Abb. 2
Abb. 3
Abb. 4

Literatur

  1. Akamatsu H, Nishijima S, Tkakashi M et al. (2001) Effects of subminimal inhibitory concentrations of erythromycin, tetracycline, clindamycin and minocycline on the neutrophil chemotactic factor production in Propionibacterium acnes biotypes 1–5. J Dermatol 18: 247–251

    Google Scholar 

  2. Akhavan A, Bershad S (2003) Topical acne drugs. Review of clinical properties, systemic exposure and safety. Am J Clin Dermatol 4: 473–492

    Article  PubMed  Google Scholar 

  3. Arnold AW, Itin P (2006) Therapie der Acne vulgaris. Schweiz Med Forum 6: 576–582

    Google Scholar 

  4. Barza M, Goldstein JA, Kane A et al. (1982) Systemic adsorption of clindamycin hydrochloride after topical application. J Am Acad Dermatol 7: 208–214

    Article  PubMed  CAS  Google Scholar 

  5. Chassard D, Kanis R, Namour F et al. (2006) A single centre, open-label, cross-over study of pharmacokinetics comparing topical zinc clindamycin gel (Zindaclin®) and topical clindamycin lotion (Dalacin® T) in subjects with mild to moderate acne. J Dermatol Treat 17: 154–157

    Article  CAS  Google Scholar 

  6. Cunliffe WJ, Fernandez C, Bojar R et al. (2005) An observer-blind, parallel-group, randomized, multicentre clinical and microbiological study of a topical clindamycin/zinc gel and a topical clindamycin lotion in patients with mild/moderate acne. J Dermatol Treat 16: 213–218

    Article  CAS  Google Scholar 

  7. Del Rosso JQ (2006) Combination topical therapy in the treatment of acne. Cutis 78 (Suppl 2[i]): 5–12

  8. Dreno B (2004) Topical antibacterial therapy for acne vulgaris. Drugs 64: 2389–2397

    Article  PubMed  CAS  Google Scholar 

  9. Eller MG, Smith RB, Phillips JB (1989) Absorption kinetics of topical clindamycin preparations. Biopharm Drug Dispos 10: 505–512

    Article  PubMed  CAS  Google Scholar 

  10. Franz TJ (1983) On the bioavailability of topical formulations of clindamycin hydrochloride. J Am Acad Dermatol 9: 66–73

    Article  PubMed  CAS  Google Scholar 

  11. Gallerani M, Ricci L, Calo G, Manfredini R (1997): Abdominal pain and diarrhoea caused by topical clindamycin phosphate. Clin Drug Invest 14: 243–245

    CAS  Google Scholar 

  12. Guin JD, Reynolds R, Gielerak PL (1980) Penetration of topical clindamycin into comedones. J Am Acad Dermatol 3: 153–156

    Article  PubMed  CAS  Google Scholar 

  13. IMS Health (2003) http://www.imshealth.de

  14. Jain GK, Ahmed FJ (2007) Adapalene pre-treatment increases follicular penetration of clindamycin: in vitro and in vivo studies. Indian J Dermatol Venereol Leprol 73: 326–329

    Article  PubMed  Google Scholar 

  15. James WD (2005) Acne. N Engl J Med 352: 1463–1472

    Article  PubMed  CAS  Google Scholar 

  16. Katsambas AD, Stefanaki C, Cunliffe WJ (2004) Guidelines for treating acne. Clin Dermatol 22: 439–444

    Article  PubMed  Google Scholar 

  17. Kellett N, West F, Finlay AY (2006) Conjoint analysis: a novel, rigorous tool for determining patient preferences for topical antibiotic treatment for acne. A randomized controlled trial. Br J Dermatol 154: 524–532

    Article  PubMed  CAS  Google Scholar 

  18. Lomaestro BM, Bailie GR (1991) Quinolone-cation interactions: a review. DICP 25: 1249–1258

    PubMed  CAS  Google Scholar 

  19. Nishijima S, Kurokowa I, Katoh N, Watanabe K (2000) The bacteriology of acne vulgaris and antimicrobial susceptibility of Propionibacterium acnes and Staphylococcus epidermis isolated from acne lesions. J Dermatol 27: 318–323

    PubMed  CAS  Google Scholar 

  20. Oprica C, Emtestam L, Lapins J et al. (2004) Antibiotic-resistant Propionibacterium acnes on the skin of patients with moderate to severe acne in Stockholm. Anaerobe 10: 155–164

    Article  PubMed  Google Scholar 

  21. Oprica C, Nord CE on behalf of the ESCMID Study Group on Antimicrobial Resistance in Anaerobic Bacteria (2005) European surveillance study on the antibiotic susceptibility of Propionibacterium acnes. Clin Microbiol Infect 11: 204–213

    Article  PubMed  CAS  Google Scholar 

  22. Sato E, Kato M, Kohno M, Niwano Y (2007) Clindamycin phosphate scavenges hydroxyl radical. Int J Dermatol 46: 1185–1187

    Article  PubMed  CAS  Google Scholar 

  23. Schachner L, Pestana A, Kittles C (1990) A clinical trial comparing the safety and efficacy of topical erythromycin-zinc formulation with a topical clindamycin formulation. J Am Acad Dermatol 22: 489–495

    Article  PubMed  CAS  Google Scholar 

  24. Schiedermayer DL, Loo FD (1987) Topical clindamycin-associated diarrhoea – case report and review of the literature. Wis Med J 86: 29–30

    PubMed  CAS  Google Scholar 

  25. Simonart T, Dramaix M (2005) Treatment of acne with topical antibiotics: lessons from clinical studies. Br J Dermatol 153: 395–403

    Article  PubMed  CAS  Google Scholar 

  26. Tan HH (2004) Topical antibacterial treatments for acne vulgaris: comparative review and guide for selection. Am J Clin Dermatol 5: 79–84

    Article  PubMed  CAS  Google Scholar 

  27. Toyoda M, Morohashi M (1998) An overview of topical antibiotics for acne treatment. Dermatology 196: 130–134

    Article  PubMed  CAS  Google Scholar 

  28. Unkles SE, Gemmel GG (1982) Effect of clindamycin, erythromycin, lincomycin, and tetracycline on growth and extracellular lipase production by propionibacterium in vitro. Antimicrob Agent Chemother 21: 39–43

    CAS  Google Scholar 

  29. Van Hoogdalem EJ, Baven TLM, Spiegel-Melsen I, Terpstra IJ (1998) Transdermal absorption of clindamycin and tretinoin from topically applied anti-acne formulations in man. Biopharm Drug Dispos 19: 563–569

    Article  Google Scholar 

  30. Van Hoogdalem EJ (1998) Transdermal absorption of topical anti-acne agents in man; review of clinical pharmacokinetic data. J Eur Acad Dermatol Venereol 11 (Suppl 1): 13–19

    Google Scholar 

  31. Warner GT, Plosker GL (2002) Clindamycin/benzoyl peroxide gel: a review of its use in the management of acne. Am J Clin Dermatol 3: 349–360

    Article  PubMed  Google Scholar 

  32. Worret WI, Fluhr JW (2006) Acne therapy with topical benzoyl peroxide, antibiotics and azelaic acid. JDDG 4: 293–300

    Article  PubMed  Google Scholar 

  33. Zouboulis C, Derumeaux L, Decroix J et al. (2000) A multicentre, single-blind, randomized comparison of a clindamycin phosphate/tretinoin gel formulation (Velac®) applied once daily and a clindymycin lotion formulation (Dalacin T®) applied twice daily in the topical treatment of acne vulgaris. Br J Dermatol 143: 498–505

    Article  PubMed  CAS  Google Scholar 

  34. Zouboulis C, Eady A, Goldsmith LA et al. (2005) What is the pathogenesis of acne? Exp Dermatol 14: 143–152

    Article  PubMed  CAS  Google Scholar 

Download references

Interessenkonflikt

Der korrespondierende Autor weist auf folgende Beziehungen hin: Prof. Dr. H.C. Korting kooperiert mit der Firma York bei der Entwicklung innovativer Dermatika. Die Erstellung der vorliegenden Arbeit wurde ermöglicht durch eine finanzielle Unterstützung der Firma York Pharma GmbH, Homberg/Ohm, für Frau Dr. C. Schöllmann.

Author information

Authors and Affiliations

  1. Klinik und Poliklinik für Dermatologie und Allergologie, Klinikum der Ludwig-Maximilians-Universität München, Frauenlobstraße 9–11, 80337, München, Deutschland

    H.C. Korting & C. Schöllmann

Authors
  1. H.C. Korting
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. C. Schöllmann
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to H.C. Korting.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Korting, H., Schöllmann, C. Management der Acne vulgaris: Fokus auf Clindamycin und Zink. Hautarzt 60, 42–47 (2009). https://doi.org/10.1007/s00105-008-1669-x

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00105-008-1669-x

Schlüsselwörter

Keywords

Search

Navigation