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Sensibilisierung auf p-Phenylendiamin

Einfluss von Metabolisierung und individuellen Risikofaktoren

Sensitisation to p-Phenylenediamine

Effects of metabolism and individual susceptibility

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Zusammenfassung

Die Haut ist Zielorgan allergischer Reaktionen auf kleinmolekulare Stoffe. Ein häufiges und starkes Kontaktallergen stellt para-Phenylendiamin (PPD) dar. Die Untersuchungen der letzten Jahre haben neue Erkenntnisse über die Abläufe bei der Sensibilisierung und allergischen Kontaktdermatitis auf PPD erbracht. Hierbei konnten wichtige Informationen über die Metabolisierung kleinmolekularer Stoffe in der Haut und deren Beteiligung bei der Aktivierung bzw. Deaktivierung immunogener Substanzen gewonnen werden. Molekularepidemiologische Studien weisen darauf hin, dass genetische Polymorphismen möglicherweise diese Vorgänge und damit das individuelle Sensibilisierungsrisiko beeinflussen.

Abstract

Due to its constant exposure to small molecular weight compounds, the skin is a major target for allergic reactions. Para-phenylenediamine (PPD) is a common and strong contact allergen. Recent studies have revealed new aspects of steps involved in sensitization and allergic contact dermatitis to PPD, giving insight into the cutaneous metabolism of small molecular compounds and its effect on activation and deactivation of immunogenic substances. Molecular epidemiological studies have suggested that polymorphisms in genes encoding cytokines (e.g. TNF-alpha) or metabolizing enzymes (e.g. N-acetyltransferase) may have influence on these mechanisms and the individual susceptibility for sensitization.

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Authors and Affiliations

  1. Klinik für Dermatologie und Allergologie, Universitätsklinikum der RWTH Aachen, Pauwelsstraße 30, 52074, Aachen, Deutschland

    R. Brans, C. Skazik & H.F. Merk

  2. Fachbereich VI Ökotoxikologie und Toxikologie, Universität Trier, Am Wissenschaftspark 25–27, 54296, Trier, Deutschland

    B. Blömeke

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  1. R. Brans
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  2. C. Skazik
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  3. H.F. Merk
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  4. B. Blömeke
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Correspondence to R. Brans or B. Blömeke.

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Brans, R., Skazik, C., Merk, H. et al. Sensibilisierung auf p-Phenylendiamin. Hautarzt 60, 26–31 (2009). https://doi.org/10.1007/s00105-008-1643-7

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  • DOI: https://doi.org/10.1007/s00105-008-1643-7

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