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Genitaler Herpes und HSV-Transmission bei HIV-Patienten

Genital herpes and HSV transmission in HIV patients

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Zusammenfassung

Es besteht eine bidirektionale Beziehung zwischen HSV-2 und HIV-1 sowohl auf zellulärer Ebene als auch bezüglich Transmission und ggf. Progression der HIV-1-Infektion. Es gibt deutliche Hinweise auf einen positiven Effekt einer antiherpetischen Therapie auf die Reduktion der HIV-1-Plasma- und Mukosaviruslast und HIV-1-Transmissionsrate. Die serologische Testung auf HSV-2 bei Personen mit erhöhtem HIV-1-Risiko sowie die Aufklärung der bidirektionalen Interaktion von HSV-2 und HIV-1 und eine entsprechende antiherpetische Suppressionstherapie können sowohl die HIV-1-Transmissionsrate senken, als auch zu einem individuellen klinischen Benefit der HIV-1-Infektion führen.

Abstract

There is a bidirectional relationship between HSV-2 and HIV-1, both at the cellular level, as well as regarding transmission and even progression of HIV-1 infection. There is clear evidence that anti-herpetic therapy reduces the plasma and mucosal HIV-1 viral load, as well as transmission. Serologic testing for HSV-2 in patients with an increased HIV-1 risk, coupled with a better understanding of the interaction between the viruses and appropriate anti-herpetic suppression therapy could both reduce the HIV-1 transmission rate and help the individual with an HIV infection.

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Literatur

  1. Bahrt B, Rabenau HF, Weber B et al. (1992) Prävalenz Herpes-simplex-Virus-Typ 2-spezifischer Antikörper bei Personen mit unterschiedlichem Infektionsrisiko. Z Hautkr 67(1): 56–58

    Google Scholar 

  2. Buxbaum S, Geers M, Gross G et al. (2003) Epidemiology of herpes simplex virus types 1 and 2 in Germany: what has changed? J Med Microbiol Immunol 192(3): 177–181

    Article  CAS  Google Scholar 

  3. Celum CL (2004) The interaction between herpes simplex virus and human immunodeficiency virus. Herpes (Suppl 1): 36A–45A

  4. Chenot JF, Doerr HW, Rabenau HF (2001) Laboratory diagnosis of herpes genitalis. Lab Med 25(7/8): 223–225

    Google Scholar 

  5. Chenot JF, Rabenau HF, Doerr HW (1999) Virologie, Epidemiologie und Diagnostik des Herpes genitalis. Dtsch Med Wochenschr 124: 158–162

    Article  PubMed  CAS  Google Scholar 

  6. Corey (2007) Synergistic Copathogens – HIV-1 and HSV-2. N Engl J Med 356(8): 854–856

    Article  PubMed  CAS  Google Scholar 

  7. Corey L (2007) Herpes simplex virus type 2 and HIV-1: the dialogue between the 2 organisms continues. J Infect Dis 195(9): 1242–1244

    Article  PubMed  Google Scholar 

  8. Doerr HW, Rabenau HF (1996) Dermatotrope Herpesviren: Infektionsbiologie, Epidemiologie und Diagnostik. Chemother J 5 (Suppl 10): 1–11

    Article  Google Scholar 

  9. Doerr HW, Rabenau HF (2001) Die Laboratoriumsdiagnose von Infektionen mit Herpes simplex Virus (HSV), Cytomegalievirus (CMV) und Chlamydia trachomatis: Beiträge zur Optimierung konventioneller und molekularbiologischer Methoden des Erregernachweises. Pabst Science Publishers, Lengerich

  10. Drake AL, John-Stewart GC, Wald A et al. (2007) Herpes simplex virus type 2 and risk of intrapartum human immunodeficiency virus transmission. Obstet Gynecol 109(2 Pt 1): 403–409

    PubMed  CAS  Google Scholar 

  11. Golden MP, Kim S, Hammer SM et al. (1992) Activation of human immunodeficiency virus by herpes simplex virus. J Infect Dis 166: 494–499

    PubMed  CAS  Google Scholar 

  12. Gray RH, Wawer MJ, Brookmeyer R et al. (2001). Probability of HIV-1 transmission per coital act in monogamous, heterosexual, HIV-1-discordant couples in Rakai, Uganda. Lancet 357(9263): 1149–1153

    Article  PubMed  CAS  Google Scholar 

  13. Haas I, Mühlbauer G, Bozic M et al. (2004) Evaluation of a new assay for detection of herpes simplex virus type 1 and type 2 DNA by real-time PCR. J Lab Med 28(4): 361–367

    CAS  Google Scholar 

  14. Kessler HH, Mühlbauer G, Rinner B et al. (2000) Detection of herpes simplex virus DNA by real-time PCR. J Clin Microbiol 38(7): 2638–2642

    PubMed  CAS  Google Scholar 

  15. Lafferty WE, Coombs RW, Benedetti J et al. (1987) Recurrences after oral and genital herpes simplex virus infection. Influence of site of infection and viral type. N Engl J Med. 316(23): 1444–1449

    Google Scholar 

  16. Lafferty WE, Downey L, Celum C, Wald A (2000) Herpes simplex virus type 1 as a cause of genital herpes: impact on surveillance and prevention. J Infect Dis 181(4): 1454–1457

    Article  PubMed  CAS  Google Scholar 

  17. Langenberg AG, Corey L, Ashley RL et al. (1999) A prospective study of new infections with herpes simplex virus type 1 and type 2. Chiron HSV Vaccine Study Group. N Engl J Med 341(19): 1432–1438

    Article  PubMed  CAS  Google Scholar 

  18. Lingappa JR, Celum C (2007) Clinical and therapeutic issues for herpes simplex virus-2 and HIV Co-infection. Drugs 67(2): 155–174

    Article  PubMed  CAS  Google Scholar 

  19. Lowhagen GB, Tunback P, Andersson K et al. (2000) First episodes of genital herpes in a Swedish STD population: a study of epidemiology and transmission by the use of herpes simplex virus (HSV) typing and specific serology. Sex Transm Infect 76(3): 179–182

    Article  PubMed  CAS  Google Scholar 

  20. Mbopi-Keou FX, Gresenguet G, Mayaud P et al. (2000) Interactions between herpes simplex virus type 2 and human immunodeficiency virus type 1 infection in African women: opportunities for intervention. J Infect Dis 182(4): 1090–1096

    Article  PubMed  CAS  Google Scholar 

  21. Mindel A (1995) Recent advances in genital herpes. Ann Acad Med Singapore 24(4): 584–592

    PubMed  CAS  Google Scholar 

  22. Nagot N, Ouedraogo A, Foulongne V et al. (2007) Reduction of HIV-1 RNA levels with therapy to suppress herpes simplex virus. N Engl J Med 356(8): 790–799

    Article  PubMed  CAS  Google Scholar 

  23. Nilsen A, Myrmel H (2000) Changing trends in genital herpes simplex virus infection in Bergen, Norway. Acta Obstet Gynecol Scand 79(8): 693–696

    Article  PubMed  CAS  Google Scholar 

  24. Palu G, Benetti L, Calistri A (2001) Molecular basis of the interactions between herpes simplex viruses and HIV-1. Herpes 8(2): 50–55

    PubMed  CAS  Google Scholar 

  25. Preiser W, Doerr HW, Buxbaum S et al. (2004) Acute retinal necrosis six years after herpes simplex encephalitis: an elusive immune deficit suggested by insufficient test sensitivity. J Med Virol 73(2): 250–255

    Article  PubMed  CAS  Google Scholar 

  26. Preiser W, Rabenau HF, Doerr HW (2002) Viren – Viruserkrankungen – Synopsis der Klinik, Diagnostik und Therapie viraler Erkrankungen. Zett, Steinen, S 1–228

  27. Rabenau HF, Berger A (2006) Indikationen für die molekulare Diagnostik – Viren. In: Thiemann, Cullen, Klein (Hrsg) Leitfaden für die molekulare Diagnostik. Grundlagen, Tipps und Tricks für die Praxis. Wissenschaftsverlag Wiley-VCH, Weinheim, S 145–174

  28. Rabenau HF, Buxbaum S, Preiser W et al. (2002) Seroprevalence of herpes simplex virus types 1 and type 2 in the Frankfurt am Main area, Germany. J Med Microbiol Immunol 190: 153–160

    Article  CAS  Google Scholar 

  29. Rabenau HF, Eibner J, Weber B, Doerr HW (1992) Detection of Herpes simplex virus (HSV) type specific antibodies by a microtechnique Western blot assay. Lab Med 16: 327–331

    CAS  Google Scholar 

  30. Rabenau HF, Helmerich A, Weber B (1999) Verbesserte Labordiagnose der Herpes simplex Virus Infektion: Evaluierung eines modifizierten schnellen Shell-Vial-Assays zur Detektion und Typisierung von Herpes simplex Viren. Lab Med 23(11): 614–620

    CAS  Google Scholar 

  31. Rabenau HF, Runne U, Selb B, Doerr HW (1986) Die Labordiagnose von Herpes simplex: Nachweis von Virusantigen mit dem Enzyme-linked-immunosorbent-assay und dem direkten Immunfluoreszenztest. Lab Med 10: 324–326

    Google Scholar 

  32. Sakrauski A, Weber B, Kessler HH et al. (1994) Comparison of two hybridization assays for the rapid detection of PCR amplified HSV genome sequences from cerebrospinal fluid. J Virol Methods 50(1–3): 175–184

    Google Scholar 

  33. Schacker T (2001) The role of HSV in the transmission and progression of HIV. Herpes 8(2): 46–49

    PubMed  CAS  Google Scholar 

  34. Schacker T, Zeh J, Hu HL et al. (1998) Frequency of symptomatic and asymptomatic herpes simplex virus type 2 reactivations among human immunodeficiency virus-infected men. J Infect Dis 178(6): 1616–1622

    Article  PubMed  CAS  Google Scholar 

  35. Singh R, Kumar A, Creery WD et al. (2003) Dysregulated expression of IFN-gamma and IL-10 and impaired IFN-gamma-mediated responses at different disease stages in patients with genital herpes simplex virus-2 infection. Clin Exp Immunol 133(1): 97–107

    Article  PubMed  CAS  Google Scholar 

  36. Smith JS, Robinson NJ (2002) Age-specific prevalence of infection with herpes simplex virus types 2 and 1: a global review. J Infect Dis;186 (Suppl 1): S3–28

    Google Scholar 

  37. Vogel JU, Weber B, Doerr HW (1994) Typing and strain differentiation of clinical herpes simplex virus type 1 and 2 isolates by polymerase chain reaction and subsequent restriction fragment length polymorphism analysis. Zentralbl Bakteriol 281(4): 502–512

    PubMed  CAS  Google Scholar 

  38. Wald A, Link K (2002) Risk of human immunodeficiency virus infection in herpes simplex virus type 2-seropositive persons: a meta-analysis. J Infect Dis 185(1): 45–52

    Article  PubMed  Google Scholar 

  39. Wutzler P, Doerr HW, Färber I et al. (2000) Seroprevalence of herpes simplex virus type 1 and type 2 in selected German populations – relation and relevance for the incidence of herpes genitalis. J Medical Virol 61: 201–207

    Article  CAS  Google Scholar 

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  1. Institut für Medizinische Virologie, Klinikum der Johann Wolfgang Goethe-Universität Frankfurt, Paul-Ehrlich-Straße 40, 60596, Frankfurt, Deutschland

    H.F. Rabenau & H.W. Doerr

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  1. H.F. Rabenau
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  2. H.W. Doerr
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Correspondence to H.F. Rabenau.

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Rabenau, H., Doerr, H. Genitaler Herpes und HSV-Transmission bei HIV-Patienten. Hautarzt 59, 11–17 (2008). https://doi.org/10.1007/s00105-007-1443-5

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