Zusammenfassung
Wir berichten hier über den Fall von Patienten mit multiplen Abszessen durch Panton-Valentin-Leukozidin- (PVL-)positiven Staphylococcus aureus. Die Produktion dieses Zytotoxins stellt mutmaßlich einen entscheidenden Virulenzfaktor dar. Typische Erkrankungen durch diese Erreger sind rezidivierende Abszesse der Haut. Selten treten nekrotisierende Pneumonien mit hoher Letalitätsrate auf. Auch Methicillin-resistente PVL-positive Stämme sind in Deutschland bereits beschrieben worden. Erst die konsequente Anwendung geeigneter Hygienemaßnahmen zusammen mit einer adäquaten antimikrobiellen Therapie führte zur Sanierung. Hautärzte sollten über dieses Krankheitsbild und die erforderlichen Maßnahmen informiert sein.
Abstract
We report cases of immunocompetent patients showing multiple abscesses by a Panton-Valentine leukocidin (PVL) positive Staphylococcus aureus. PVL is considered to be an important virulence factor. The most common manifestations by this pathogen are recurrent or multiple abscesses of the skin. Seldom necrotizing pneumonia with high mortality occurs. Even methicillin-resistant PVL positive isolates have been identified in Germany. Only appropriate infection control measures in combination with antimicrobial therapy resulted in successful eradication of this pathogen. Dermatologists should be informed about this specific type of infection and about the appropriate infection control measures.
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Vonberg, RP., Sedlacek, L., Chaberny, I. et al. Multiple Abszesse bei immunkompetenten Patienten durch Panton-Valentin-Leukozidin-positiven Staphylococcus aureus . Hautarzt 59, 319–322 (2008). https://doi.org/10.1007/s00105-007-1374-1
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DOI: https://doi.org/10.1007/s00105-007-1374-1