Skip to main content
SpringerLink
Log in

Urtikaria

„From bench to bedside“

Urticaria

“From bench to bedside”

  • Leitthema
  • Published:
Der Hautarzt Aims and scope Submit manuscript

Zusammenfassung

In den vergangenen Jahren haben zahlreiche experimentelle und epidemiologische Arbeiten entscheidende Fortschritte für das Verständnis der Ätiopathogenese der Urtikaria erbracht. Weiterhin konnten neue Instrumente für die Diagnostik und für die Bestimmung der Lebensqualität bei Urtikariapatienten erarbeitet werden. Auch die Therapie der chronischen Urtikaria hat sich durch die Ergebnisse mehrerer wichtiger Studien in den vergangenen Jahren verändert, und für die nahe Zukunft sind neue therapeutische Konzepte zu erwarten. Der vorliegende Übersichtsbeitrag bespricht einzelne neue Erkenntnisse aus diesen Bereichen der Urtikariaforschung und deren Relevanz für die Praxis.

Abstract

A number of recent epidemiologic and experimental studies have enhanced our knowledge of the etiology and pathogenesis of urticaria. In addition, new instruments for diagnosing urticaria variants and for assessing the quality of life in urticaria patients have been developed. Finally, several clinical trials have demonstrated the efficacy of novel treatment approaches for urticaria, while other therapeutic concepts are under development. Here, we provide a brief review of selected findings from these recent reports and a discussion of their relevance for clinical practice.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Abb. 1
Abb. 2

Literatur

  1. Asero R, Tedeschi A, Riboldi P, Cugno M (2006) Plasma of patients with chronic urticaria shows signs of thrombin generation, and its intradermal injection causes wheal-and-flare reactions much more frequently than autologous serum. J Allergy Clin Immunol 117: 1113–1117

    Article  PubMed  Google Scholar 

  2. Assanasen P, Naclerio RM (2002) Antiallergic anti-inflammatory effects of H1-antihistamines in humans. Clin Allergy Immunol 17: 101–139

    PubMed  Google Scholar 

  3. Baiardini I, Pasquali M, Braido F et al. (2005) A new tool to evaluate the impact of chronic urticaria on quality of life: chronic urticaria quality of life questionnaire (CU-QoL). Allergy 60: 1073–1078

    Article  PubMed  Google Scholar 

  4. Caproni M, Volpi W, Giomi B et al. (2004) Chronic idiopathic and chronic autoimmune urticaria: clinical and immunopathological features of 68 subjects. Acta Derm Venereol 84: 288–290

    Article  PubMed  Google Scholar 

  5. Caproni M, Volpi W, Giomi B et al. (2006) Cellular adhesion molecules in chronic urticaria: modulation of serum levels occurs during levocetirizine treatment. Br J Dermatol 155: 1270–1274

    Article  PubMed  Google Scholar 

  6. Chren MM, Lasek RJ, Flocke SA, Zyzanski SJ (1997) Improved discriminative and evaluative capability of a refined version of Skindex, a quality-of-life instrument for patients with skin diseases. Arch Dermatol 133: 1433–1440

    Article  PubMed  Google Scholar 

  7. Di Lorenzo G, Pacor ML, Mansueto P et al. (2004) Randomized placebo-controlled trial comparing desloratadine and montelukast in monotherapy and desloratadine plus montelukast in combined therapy for chronic idiopathic urticaria. J Allergy Clin Immunol 114: 619–625

    Article  PubMed  Google Scholar 

  8. Fagiolo U, Kricek F, Ruf C et al. (2000) Effects of complement inactivation and IgG depletion on skin reactivity to autologous serum in chronic idiopathic urticaria. J Allergy Clin Immunol 106: 567–572

    Article  PubMed  Google Scholar 

  9. Genovese A, Patella V, De Crescenzo G et al. (1997) Loratadine and desethoxylcarbonyl-loratadine inhibit the immunological release of mediators from human Fc epsilon RI+ cells. Clin Exp Allergy 27: 559–567

    Article  PubMed  Google Scholar 

  10. Gonzalez Morales JE, Leal Villareal L, Castillo Salazar Nde J et al. (2005) [Correlation between chronic idiopathic urticaria and infection due to H. pylori]. Rev Alerg Mex 52: 179–182

    PubMed  Google Scholar 

  11. Grattan CE, Francis DM, Hide M, Greaves MW (1991) Detection of circulating histamine releasing autoantibodies with functional properties of anti-IgE in chronic urticaria. Clin Exp Allergy 21: 695–704

    Article  PubMed  Google Scholar 

  12. Grattan CE, Wallington TB, Warin RP et al. (1986) A serological mediator in chronic idiopathic urticaria – a clinical, immunological and histological evaluation. Br J Dermatol 114: 583–590

    Article  PubMed  Google Scholar 

  13. Greaves M (2002) Autoimmune urticaria. Clin Rev Allergy Immunol 23: 171–183

    Article  PubMed  Google Scholar 

  14. Grob JJ, Revuz J, Ortonne JP et al. (2005) Comparative study of the impact of chronic urticaria, psoriasis and atopic dermatitis on the quality of life. Br J Dermatol 152: 289–295

    Article  PubMed  Google Scholar 

  15. Hide M, Francis DM, Grattan CE et al. (1993) Autoantibodies against the high-affinity IgE receptor as a cause of histamine release in chronic urticaria. N Engl J Med 328: 1599–1604

    Article  PubMed  Google Scholar 

  16. Hidvegi B, Nagy E, Szabo T et al. (2003) Correlation between T-cell and mast cell activity in patients with chronic urticaria. Int Arch Allergy Immunol 132: 177–182

    Article  PubMed  Google Scholar 

  17. Kasperska-Zajac A, Brzoza Z, Rogala B (2006) Lower serum concentration of dehydroepiandrosterone sulphate in patients suffering from chronic idiopathic urticaria. Allergy 61: 1489–1490

    Article  PubMed  Google Scholar 

  18. Kessel A, Bishara R, Amital A et al. (2005) Increased plasma levels of matrix metalloproteinase-9 are associated with the severity of chronic urticaria. Clin Exp Allergy 35: 221–225

    Article  PubMed  Google Scholar 

  19. Klemparskaya NN, Shalnova GA, Ulanova AM et al. (1986) Immunomodulating effect of autohaemotherapy (a literature review). J Hyg Epidemiol Microbiol Immunol 30: 331–336

    PubMed  Google Scholar 

  20. Lin RY, Schwartz LB, Curry A et al. (2000) Histamine and tryptase levels in patients with acute allergic reactions: An emergency department-based study. J Allergy Clin Immunol 106: 65–71

    Article  PubMed  Google Scholar 

  21. Malmros H (1946) Autoserumtest. Nordisk Med 29: 150–151

    Google Scholar 

  22. Maurer M, Hanau A, Metz M et al. (2003) Relevance of food allergies and intolerance reactions as causes of urticaria. Hautarzt 54: 138–143

    PubMed  Google Scholar 

  23. Maurer M, Metz M, Magerl M et al. (2004) Autoreactive urticaria and autoimmune urticaria. Hautarzt 55: 350–356

    Article  PubMed  Google Scholar 

  24. Mete N, Gulbahar O, Aydin A et al. (2004) Low B12 levels in chronic idiopathic urticaria. J Investig Allergol Clin Immunol 14: 292–299

    PubMed  Google Scholar 

  25. Molet S, Gosset P, Lassalle P et al. (1997) Inhibitory activity of loratadine and descarboxyethoxyloratadine on histamine-induced activation of endothelial cells. Clin Exp Allergy 27: 1167–1174

    Article  PubMed  Google Scholar 

  26. 26. Nettis E, Colanardi MC, Paradiso MT, Ferrannini A (2004) Desloratadine in combination with montelukast in the treatment of chronic urticaria: a randomized, double-blind, placebo-controlled study. Clin Exp Allergy 34: 1401–1407

    Article  PubMed  Google Scholar 

  27. Nettis E, Colanardi MC, Soccio AL et al. (2006) Desloratadine in combination with montelukast suppresses the dermographometer challenge test papule, and is effective in the treatment of delayed pressure urticaria: a randomized, double-blind, placebo-controlled study. Br J Dermatol 155: 1279–1282

    Article  PubMed  Google Scholar 

  28. Nettis E, Dambra P, D’Oronzio L et al. (2002) Reactivity to autologous serum skin test and clinical features in chronic idiopathic urticaria. Clin Exp Dermatol 27: 29–31

    Article  PubMed  Google Scholar 

  29. Ohbayashi H, Shimokata K (2005) Matrix metalloproteinase-9 and airway remodeling in asthma. Curr Drug Targets Inflamm Allergy 4: 177–181

    Article  PubMed  Google Scholar 

  30. Piconi S, Trabattoni D, Iemoli E et al. (2002) Immune profiles of patients with chronic idiopathic urticaria. Int Arch Allergy Immunol 128: 59–66

    Article  PubMed  Google Scholar 

  31. Sabroe RA, Seed PT, Francis DM et al. (1999) Chronic idiopathic urticaria: comparison of the clinical features of patients with and without anti-FcepsilonRI or anti-IgE autoantibodies. J Am Acad Dermatol 40: 443–450

    Article  PubMed  Google Scholar 

  32. Staubach P, Eckhardt-Henn A, Dechene M et al. (2006) Quality of life in patients with chronic urticaria is differentially impaired and determined by psychiatric comorbidity. Br J Dermatol 154: 294–298

    Article  PubMed  Google Scholar 

  33. Staubach P, Onnen K, Vonend A et al. (2006) Autologous whole blood injections to patients with chronic urticaria and a positive autologous serum skin test: a placebo-controlled trial. Dermatology 212: 150–159

    Article  PubMed  Google Scholar 

  34. Török L (1928) Urticaria (Nesselausschlag). In: Jadassohn (Hrsg) Handbuch der Haut- und Geschlechtskrankheiten. Springer, Berlin, S 145–215

  35. Traidl-Hoffmann C, Munster I, Ring J, Behrendt H (2006) Impact of desloratadine and loratadine on the crosstalk between human keratinocytes and leukocytes: Implications for anti-inflammatory activity of antihistamines. Int Arch Allergy Immunol 140: 315–320

    Article  PubMed  Google Scholar 

  36. Van den Steen PE, Dubois B, Nelissen I et al. (2002) Biochemistry and molecular biology of gelatinase B or matrix metalloproteinase-9 (MMP-9). Crit Rev Biochem Mol Biol 37: 375–536

    Article  PubMed  Google Scholar 

  37. Zuberbier T, Bindslev-Jensen C, Canonica W et al. (2006) EAACI/GA2LEN/EDF guideline: definition, classification and diagnosis of urticaria. Allergy 61: 316–320

    Article  PubMed  Google Scholar 

  38. Zuberbier T, Bindslev-Jensen C, Canonica W et al. (2006) EAACI/GA2LEN/EDF guideline: management of urticaria. Allergy 61: 321–331

    Article  PubMed  Google Scholar 

  39. Zuberbier T, Schadendorf D, Haas N et al. (1997) Enhanced P-selectin expression in chronic and dermographic urticaria. Int Arch Allergy Immunol 114: 86–89

    PubMed  Google Scholar 

Download references

Interessenkonflikt

Es besteht kein Interessenkonflikt. Der korrespondierende Autor versichert, dass keine Verbindungen mit einer Firma, deren Produkt in dem Artikel genannt ist, oder einer Firma, die ein Konkurrenzprodukt vertreibt, bestehen. Die Präsentation des Themas ist unabhängig und die Darstellung der Inhalte produktneutral.

Author information

Authors and Affiliations

  1. Klinik für Dermatologie, Venerologie und Allergologie, Allergie-Centrum-Charité, Charité – Universitätsmedizin Berlin, Charitéplatz 1, 10117, Berlin, Deutschland

    M. Magerl &  M. Maurer

Authors
  1. M. Magerl
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M. Maurer
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to M. Maurer.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Magerl, M., Maurer, M. Urtikaria. Hautarzt 58, 308–313 (2007). https://doi.org/10.1007/s00105-007-1288-y

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00105-007-1288-y

Schlüsselwörter

Keywords

Search

Navigation