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HPV-induzierte Erkrankungen bei HIV-positiven Patienten

Human papilloma virus-induced disease in HIV-positive patients

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Zusammenfassung

Bei Human-immunodeficiency-virus (HIV)-positiven Patienten konnten durch die Einführung der hochaktiven antiretroviralen Therapie (HAART) viele opportunistische Infektionen durch Bakterien und Pilze zurückgedrängt werden. Bei den durch humanes Papilloma-Virus (HPV) ausgelösten Erkrankungen zeigt sich jedoch seit der Einführung der HAART zum Teil eine Zunahme. Es handelt sich dabei um das Analkarzinom sowie dessen Vorstufe, die anale intraepitheliale Neoplasie (AIN), die bei HIV-Patienten vermehrt auftritt. Ebenso kommt es vermehrt zum Zervixkarzinom und dessen Vorstufen sowie zu oralen Warzen und Kondylomen. Um eine AIN frühzeitig zu erkennen, müssen HIV-Patienten regelmäßig proktologisch untersucht werden. Dabei sollten für eine optimale Diagnostik eine Anoskopie, die der Kolposkopie entspricht, sowie Abstriche zur zytologischen Diagnostik durchgeführt werden.

Abstract

Since the introduction of highly active antiretroviral therapy (HAART), opportunistic infections by bacteria and fungi have been reduced in human immunodeficiency virus (HIV)-positive patients. However, diseases caused by human papilloma virus (HPV) have become more frequent despite HAART. There is an increased incidence of anal and cervical carcinomas, their precancerous lesions such as anal/cervical intraepithelial neoplasia, and condylomas and oral warts. In order to prevent anal carcinomas, HIV-positive patients should receive proctoscopic examinations regularly. The examination should include anoscopy and smears for cytology and HPV polymerase chain reaction.

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Authors and Affiliations

  1. Klinik und Poliklinik für Dermatologie und Allergologie, Ludwig-Maximilians-Universität München, Frauenlobstraße 9–11, 80337 , München

    R. Wienecke

  2. St.-Josef-Hospital, Klinik für Dermatologie und Allergologie, Ruhr-Universität Bochum

    N. H. Brockmeyer & A. Kreuter

Authors
  1. R. Wienecke
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  2. N. H. Brockmeyer
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  3. A. Kreuter
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Correspondence to R. Wienecke.

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Wienecke, R., Brockmeyer, N.H. & Kreuter, A. HPV-induzierte Erkrankungen bei HIV-positiven Patienten. Hautarzt 57, 994–998 (2006). https://doi.org/10.1007/s00105-006-1236-2

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  • DOI: https://doi.org/10.1007/s00105-006-1236-2

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