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Akute generalisierte exanthematische Pustulose bei nachgewiesener Typ-IV-Allergie

Bericht über 3 Patienten

Acute generalized exanthematous pustulosis with confirmed type IV allergy

Report of 3 cases

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Zusammenfassung

Die akute generalisierte exanthematische Pustulose (AGEP) ist durch plötzliches disseminiertes Auftreten von multiplen, nichtfollikulären Pusteln gekennzeichnet. Zusätzlich kann es zu einer Verschlechterung des Allgemeinzustandes mit Fieber und einer Erhöhung der Entzündungsparameter kommen. Die Pathogenese der AGEP ist bisher unbekannt, jedoch scheinen Medikamente häufig der Auslöser für diese Erkrankung zu sein. Wir berichten über 3 Patienten mit charakteristischen klinischen und histologischen Befunden einer AGEP nach Einnahme von Amoxicillin, Ampicillin oder Diltiazem, bei denen eine positive Reaktion im Epikutantest nachgewiesen werden konnte.

Abstract

Acute generalized exanthematous pustulosis (AGEP) is characterized by an acute disseminated eruption of multiple, non-follicular pustules. In addition, it can be associated with fever, elevated erythrocyte sedimentation rate, and leukocytosis. The pathogenesis of AGEP is still unknown; however, medications appear a likely cause in most cases. We report on 3 patients with AGEP demonstrating characteristic clinical and histologic features after taking amoxicillin, ampicillin, or diltiazem. All patients had positive patch test reactions to the suspected drugs.

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  1. Hautklinik, Heinrich-Heine-Universität Düsseldorf, Moorenstraße 5, 40225 , Düsseldorf

    K. Gensch, N. Hodzic-Avdagic, M. Megahed, T. Ruzicka &  A. Kuhn

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  1. K. Gensch
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  2. N. Hodzic-Avdagic
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  3. M. Megahed
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  4. T. Ruzicka
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  5. A. Kuhn
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Correspondence to A. Kuhn.

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Gensch, K., Hodzic-Avdagic, N., Megahed, M. et al. Akute generalisierte exanthematische Pustulose bei nachgewiesener Typ-IV-Allergie. Hautarzt 58, 250–255 (2007). https://doi.org/10.1007/s00105-006-1161-4

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  • DOI: https://doi.org/10.1007/s00105-006-1161-4

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