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Probiotika und Präbiotika zur Prävention und Therapie des atopischen Ekzems

Probiotics and prebiotics for the prevention and treatment of atopic eczema

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Zusammenfassung

Die rasante Zunahme atopischer Erkrankungen gerade in westlichen Industrieländern fordert eine flächendeckende und kostengünstige Maßnahme zur Primärprävention. Bisher vorliegende Ergebnisse zum Einsatz probiotischer Milchsäurebakterien zur Prävention des atopischen Ekzems sind sehr viel versprechend. Ein therapeutischer Einsatz scheint bei Säuglingen und Kleinkindern mit leichtem bis mittelschwerem Hautbefund, sowie erhöhtem Immunglobulin E Erfolg versprechender als bei älteren Patienten ohne Sensibilisierungen. Präbiotika wie Fruktooligosaccharide und Galaktooligosaccharide führen in Abhängigkeit der Ausgangskeimzahl zu einer Vermehrung von Bifidobakterien im Kolon. Die gesundheitliche Bedeutung dieser Vermehrung in Bezug auf allergische Erkrankungen ist bisher nicht geklärt. Bei Patienten mit atopischem Ekzem konnte eine Korrelation zwischen Anzahl der Bifidobakterien in den Fäzes und dem Schweregrad des atopischen Ekzems gezeigt werden.

Abstract

The rapid increase of atopic diseases, particularly in western industrialized countries, demands comprehensive and cost-effective primary prevention. Existing findings regarding the use of probiotic lactic acid bacteria for the prevention of atopic eczema are promising. Therapeutic use appears to be more promising for infants with mild to moderate skin lesions and elevated immunoglobulin E levels than for older patients without any sensitization. Depending on the original bacterial count, prebiotics such as fructooligosaccharides and galactooligosaccharides cause an increase of bifidobacteria within the colon. The benefit of this increase in bifidobacteria in allergic diseases is unclear. In patients with atopic eczema a correlation was shown between the amount of bifidobacteria and the severity of atopic eczema.

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  1. Klinik und Poliklinik für Hautkrankheiten, Universitätsklinikum Münster

    B. Bunselmeyer

  2. Klinik und Poliklinik für Hautkrankheiten, Universitätsklinikum Münster, Von-Esmarch-Straße 58, 48149 , Münster

    B. Bunselmeyer

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Correspondence to B. Bunselmeyer.

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Bunselmeyer, B. Probiotika und Präbiotika zur Prävention und Therapie des atopischen Ekzems. Hautarzt 57, 785–791 (2006). https://doi.org/10.1007/s00105-005-1034-2

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  • DOI: https://doi.org/10.1007/s00105-005-1034-2

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