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Einfluss der Umweltnoxe Ozon auf die Haut

Influence of ozone on the the skin

Der Hautarzt volume 55, pages 1120–1124 (2004)Cite this article

Zusammenfassung

Die Haut ist zahlreichen prooxidativen Umweltnoxen wie UV-Licht und Ozon ausgesetzt. Ozon findet sich nicht nur in der Stratosphäre, wo es bekanntermaßen die stark mutagene UVC-Strahlung absorbiert, sondern in Ballungsräumen auch in der Troposphäre, d. h. als Schadstoff in der Umgebungsluft. Aufgrund der starken Oxidationsfähigkeit des Ozons ist es vermutlich eines der reaktivsten Moleküle, das auf die Haut trifft. Obwohl in zahlreichen Arbeiten die Wirkungen von Ozon auf Lungenepithelien untersucht wurden, sind erst in den letzten 10 Jahren Untersuchungen zur Entstehung von oxidativem Stress in der Haut durch Ozon durchgeführt worden. Die Exposition mit Ozon führt besonders zu Schädigungen im Bereich des Stratum corneum sowie zu einem Verbrauch kleinmolekularer Antioxidanzien, Ascorbat und Tocopherol, in den oberen Epidermislagen und entsprechend zur Entstehung von Lipid- und Proteinoxidationsprodukten. Solche Ozonationsprodukte können in tiefere Hautschichten vordringen und dort zu einer Aktivierung von Signalwegen oder stärkerer Zellschädigung führen. Im Mausmodell konnte gezeigt werden, dass umweltrelevante Ozonkonzentrationen in der Lage sind, eine Stressantwort in der Haut zu induzieren.

Abstract

The skin is directly and frequently exposed to a pro-oxidative environment, including ozone and UV-radiation. While ozone in the stratosphere protects against mutagenic UVC-radiation, it is also a major air pollutant in urban areas. With its strong oxidizing potential, ozone is perhaps one of the most reactive chemicals the skin ever encounters. Although a large body of evidence exists for ozone- induced oxidative stress in the respiratory tract, the current knowledge on its in vivo effect on cutaneous tissues is based on studies of the last 10 years. Acute ozone exposure damages the stratum corneum, depletes skin vitamin C and E and induces lipid and protein oxidation in upper epidermal layers. Secondary products penetrate into deeper skin layers and are capable of activating signal transduction pathways and inducing cell damage. It has been shown in a murine model, that environmentally relevant ozone concentrations can induce a stress response in the skin.

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Affiliations

  1. Zentrum der Dermatologie, Klinikum der J.W.-Goethe-Universität, Frankfurt

    M. Podda & J. Fuchs

  2. Zentrum der Dermatologie, Klinikum der J.W.-Goethe-Universität, Theodor-Stern-Kai 7, 60590 , Frankfurt am Main

    M. Podda

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  1. M. Podda
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  2. J. Fuchs
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Correspondence to M. Podda.

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Podda, M., Fuchs, J. Einfluss der Umweltnoxe Ozon auf die Haut. Hautarzt 55, 1120–1124 (2004). https://doi.org/10.1007/s00105-004-0842-0

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  • DOI: https://doi.org/10.1007/s00105-004-0842-0

Schlüsselwörter

  • Ozon
  • Umweltnoxe
  • Antioxidanzien
  • Reaktive Sauerstoffspezies
  • Stressantwort

Keywords

  • Ozone
  • Air pollution
  • Antioxidants
  • Reactive oxygen species
  • Stress response