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Einfluss der Umweltnoxe Ozon auf die Haut

Influence of ozone on the the skin

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Zusammenfassung

Die Haut ist zahlreichen prooxidativen Umweltnoxen wie UV-Licht und Ozon ausgesetzt. Ozon findet sich nicht nur in der Stratosphäre, wo es bekanntermaßen die stark mutagene UVC-Strahlung absorbiert, sondern in Ballungsräumen auch in der Troposphäre, d. h. als Schadstoff in der Umgebungsluft. Aufgrund der starken Oxidationsfähigkeit des Ozons ist es vermutlich eines der reaktivsten Moleküle, das auf die Haut trifft. Obwohl in zahlreichen Arbeiten die Wirkungen von Ozon auf Lungenepithelien untersucht wurden, sind erst in den letzten 10 Jahren Untersuchungen zur Entstehung von oxidativem Stress in der Haut durch Ozon durchgeführt worden. Die Exposition mit Ozon führt besonders zu Schädigungen im Bereich des Stratum corneum sowie zu einem Verbrauch kleinmolekularer Antioxidanzien, Ascorbat und Tocopherol, in den oberen Epidermislagen und entsprechend zur Entstehung von Lipid- und Proteinoxidationsprodukten. Solche Ozonationsprodukte können in tiefere Hautschichten vordringen und dort zu einer Aktivierung von Signalwegen oder stärkerer Zellschädigung führen. Im Mausmodell konnte gezeigt werden, dass umweltrelevante Ozonkonzentrationen in der Lage sind, eine Stressantwort in der Haut zu induzieren.

Abstract

The skin is directly and frequently exposed to a pro-oxidative environment, including ozone and UV-radiation. While ozone in the stratosphere protects against mutagenic UVC-radiation, it is also a major air pollutant in urban areas. With its strong oxidizing potential, ozone is perhaps one of the most reactive chemicals the skin ever encounters. Although a large body of evidence exists for ozone- induced oxidative stress in the respiratory tract, the current knowledge on its in vivo effect on cutaneous tissues is based on studies of the last 10 years. Acute ozone exposure damages the stratum corneum, depletes skin vitamin C and E and induces lipid and protein oxidation in upper epidermal layers. Secondary products penetrate into deeper skin layers and are capable of activating signal transduction pathways and inducing cell damage. It has been shown in a murine model, that environmentally relevant ozone concentrations can induce a stress response in the skin.

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Literatur

  1. Cross CE, De Lucia AJ, Reddy AK et al. (1976) Ozone interactions with lung tissue. Biochemical approaches. Am J Med 60:929–635

    Article  CAS  PubMed  Google Scholar 

  2. Finlayson-Pitts BJ, Pitts JN Jr (1997) Tropospheric air pollution: ozone, airborne toxics, polycyclic aromatic hydrocarbons, and particles. Science 276:1045–1052

    Article  CAS  PubMed  Google Scholar 

  3. Fuchs J, Huflejt ME, Rothfuss LM et al. (1989) Impairment of enzymic and nonenzymic antioxidants in skin by UVB irradiation. J Invest Dermatol 93:769–773

    Article  CAS  PubMed  Google Scholar 

  4. Giamalva D, Church DF, Pryor WA (1985) A comparison of the rates of ozonation of biological antioxidants and oleate and linoleate esters. Biochem Biophys Res Commun 133:773–779

    CAS  PubMed  Google Scholar 

  5. Haddad EB, Salmon M, Koto H et al. (1996) Ozone induction of cytokine-induced neutrophil chemoattractant (CINC) and nuclear factor-kappa b in rat lung: inhibition by corticosteroids. FEBS Lett 379:265–268

    Article  CAS  PubMed  Google Scholar 

  6. Halliwell B, Gutteridge JMC (1999) Free radicals in biology and medicine, 3rd edn. Oxford Univ. Press, Oxford, p 936

  7. Harris IR, Farrell AM, Grunfeld C et al. (1997) Permeability barrier disruption coordinately regulates mRNA levels for key enzymes of cholesterol, fatty acid, and ceramide synthesis in the epidermis. J Invest Dermatol 109:783–787

    Article  CAS  PubMed  Google Scholar 

  8. Kitazawa M, Podda M, Thiele J et al. (1997) Interactions between vitamin E homologues and ascorbate free radicals in murine skin homogenates irradiated with ultraviolet light. Photochem Photobiol 65:355–365

    CAS  PubMed  Google Scholar 

  9. Messer G, Rupec RA (2001) Nuklearfaktor-kappa-B (NF-kappa B). Teil 1: Funktion und Regulation. Hautarzt 52:677–585

    CAS  PubMed  Google Scholar 

  10. Mustafa MG (1990) Biochemical basis of ozone toxicity. Free Radic Biol Med 9:245–265

    Article  CAS  PubMed  Google Scholar 

  11. Podda M, Traber MG, Weber C et al. (1998) UV-irradiation depletes antioxidants and causes oxidative damage in a model of human skin. Free Radic Biol Med 24:55–65

    Article  CAS  PubMed  Google Scholar 

  12. Podda M, Weber C, Traber MG et al. (1999) Sensitive high-performance liquid chromatography techniques for simultaneous determination of tocopherols, tocotrienols, ubiquinols, and ubiquinones in biological samples. Methods Enzymol 299:330–341

    CAS  PubMed  Google Scholar 

  13. Podda M, Grundmann-Kollmann M (2001) Low molecular weight antioxidants and their role in skin ageing. Clin Exp Dermatol 26:578–582

    Article  CAS  PubMed  Google Scholar 

  14. Pryor WA, Church DF (1991) Aldehydes, hydrogen peroxide, and organic radicals as mediators of ozone toxicity. Free Radic Biol Med 11:41–46

    Article  CAS  PubMed  Google Scholar 

  15. Pryor WA (1992) How far does ozone penetrate into the pulmonary air/tissue boundary before it reacts? Free Radic Biol Med 12:83–88

    Article  CAS  PubMed  Google Scholar 

  16. Pryor WA, Squadrito GL, Friedman M (1995) The cascade mechanism to explain ozone toxicity: the role of lipid ozonation products. Free Radic Biol Med 19:935–941

    Article  CAS  PubMed  Google Scholar 

  17. Roehm JN, Hadley JG, Menzel DB (1971) Oxidation of unsaturated fatty acids by ozone and nitrogen dioxide. A common mechanism of action. Arch Environ Health 23:142–148

    CAS  PubMed  Google Scholar 

  18. Thiele JJ, Podda M, Packer L (1997) Tropospheric ozone: an emerging environmental stress to skin. Biol Chem 378:1299–1305

    CAS  PubMed  Google Scholar 

  19. Thiele JJ, Traber MG, Podda M et al. (1997) Ozone depletes tocopherols and tocotrienols topically applied to murine skin. FEBS Lett 401:167–170

    Article  CAS  PubMed  Google Scholar 

  20. Thiele JJ, Traber MG, Polefka TG et al. (1997) Ozone-exposure depletes vitamin E and induces lipid peroxidation in murine stratum corneum. J Invest Dermatol 108:753–757

    Article  CAS  PubMed  Google Scholar 

  21. Thiele JJ, Traber MG, Re R et al. (1998) Macromolecular carbonyls in human stratum corneum: a biomarker for environmental oxidant exposure? FEBS Lett 422:403–406

    Article  CAS  PubMed  Google Scholar 

  22. Traber MG, Sies H (1996) Vitamin E in humans: demand and delivery. Annu Rev Nutr 16:321–347

    Article  CAS  PubMed  Google Scholar 

  23. Uysal N, Schapira RM (2003) Effects of ozone on lung function and lung diseases. Curr Opin Pulm Med 9:144–150

    Article  CAS  PubMed  Google Scholar 

  24. Valacchi G, Weber SU, Luu C et al. (2000) Ozone potentiates vitamin E depletion by ultraviolet radiation in the murine stratum corneum. FEBS Lett 466:165–168

    Article  CAS  PubMed  Google Scholar 

  25. Valacchi G, van der Vliet A, Schock BC et al. (2002) Ozone exposure activates oxidative stress responses in murine skin. Toxicology 179:163–170

    Article  CAS  PubMed  Google Scholar 

  26. Valacchi G, Pagnin E, Okamoto T et al. (2003) Induction of stress proteins and MMP-9 by 0.8 ppm of ozone in murine skin. Biochem Biophys Res Commun 305:741–746

    Article  CAS  PubMed  Google Scholar 

  27. Valacchi G, Pagnin E, Corbacho AM et al. (2004) In vivo ozone exposure induces antioxidant/stress-related responses in murine lung and skin. Free Radic Biol Med 36:673–681

    Article  CAS  PubMed  Google Scholar 

  28. Weber SU, Thiele JJ, Cross CE, Packer L (1999) Vitamin C, uric acid, and glutathione gradients in murine stratum corneum and their susceptibility to ozone exposure. J Invest Dermatol 113:1128–1132

    Article  CAS  PubMed  Google Scholar 

  29. Weber SU, Jothi S, Thiele JJ (2000) High-pressure liquid chromatography analysis of ozone-induced depletion of hydrophilic and lipophilic antioxidants in murine skin. Methods Enzymol 319:536–546

    CAS  PubMed  Google Scholar 

  30. Weber SU, Packer L (2001) Ozone stress in the skin barrier. In: Fuchs J, Packer L (eds) Environmental stressors in health and disease. Marcel Dekker, New York, pp 335–343

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  1. Zentrum der Dermatologie, Klinikum der J.W.-Goethe-Universität, Frankfurt

    M. Podda & J. Fuchs

  2. Zentrum der Dermatologie, Klinikum der J.W.-Goethe-Universität, Theodor-Stern-Kai 7, 60590 , Frankfurt am Main

    M. Podda

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  1. M. Podda
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  2. J. Fuchs
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Correspondence to M. Podda.

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Podda, M., Fuchs, J. Einfluss der Umweltnoxe Ozon auf die Haut. Hautarzt 55, 1120–1124 (2004). https://doi.org/10.1007/s00105-004-0842-0

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  • DOI: https://doi.org/10.1007/s00105-004-0842-0

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