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Terbinafin-induzierter subakut-kutaner Lupus erythematodes

Farbbildkasuistik und Literaturübersicht

Terbinafine-induced subacute cutaneous lupus erythematosus

Case report and review of the literature

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Zusammenfassung

Wir schildern den Fall eines durch Terbinafin induzierten subakut-kutanen Lupus erythematodes (SCLE) in seinem klinischen, dermatohistopathologischen und immunserologischen Vollbild. Neben antinukleären Antikörpern (ANA) und positiven SS-A- (Ro-)AK ließen sich Anti-Histon-AK mit Spezifität für H1 und H3 nachweisen. Wir geben einen Überblick über die Literatur zum Terbinafin-induzierten SCLE und diskutieren den Nachweis von Antikörpern gegen Histon H1 und H3 als mögliches Kriterium zur Diagnose des medikamenteninduzierten SCLE.

Abstract

We report on a patient with terbinafine-induced SCLE covering clinical, histopathological and serological findings. Positive serological results included ANA, SS-A (Ro)-antibodies and anti-histone-antibodies with specificity for H1 and H3. The literature on terbinafine-induced SCLE is reviewed. We discuss H1- and H3-specific anti-histone antibodies as a possible diagnostic criterion of drug-induced SCLE.

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Literatur

  1. Bonsmann G, Schiller M, Luger TA, Ständer S (2001) Terbinafine-induced subacute cutaneous lupus erythematosus, J Am Acad Dermatol 44:925–931

    Google Scholar 

  2. Bork K (1999) Arzneimittelinduzierter Lupus Erythematodes. In: Arzneimittelnebenwirkungen an der Haut, 2. Aufl. Schattauer, S 157–161

  3. Braun-Falco O, Plewig G, Wolff HH (1996) Lupus-erythematodes-visceralis-artiges Syndrom. In: Dermatologie und Venerologie, 4. Aufl. Springer, Berlin Heidelberg New York Tokyo, S 750–751

  4. Braun-Falco O, Plewig G, Wolff HH (1996) Subakut-kutaner Lupus erythematodes (SCLE). In: Dermatologie und Venerologie, 4. Aufl. Springer, Berlin Heidelberg New York Tokyo, S 741–742

  5. Brooke R, Coulson IH, Al-Dawoud A (1998) Terbinafine-induced subacute cutaneous lupus erythematosus. Br J Dermatol 139:1132–1133

    Article  CAS  PubMed  Google Scholar 

  6. Brown CW, Deng JS (1995) Thiazide diuretics induce cutaneous lupus-like adverse reaction. J Toxicol Clin Toxicol 33:729–733

    CAS  PubMed  Google Scholar 

  7. Callen JP, Hughes AP, Kulp-Shorten C (2001) Subacute cutaneous lupus erythematosus induced or exacerbated by terbinafine: a report of 5 cases. Arch Dermatol 137:1196–1198

    CAS  PubMed  Google Scholar 

  8. Condon CA, Downs AMR, Archer CB (1998) Terbinafine-induced acute generalized exanthematous pustulosis. Br J Dermatol 138:709–710

    Article  CAS  PubMed  Google Scholar 

  9. Darken M, McBurney EI (1988) Subacute cutaneous lupus erythematosus-like drug eruption due to combination diuretic hydrochlorothiazide and triamterene. J Am Acad Dermatol 18(1Pt 1):38–42

    CAS  PubMed  Google Scholar 

  10. Finlay A (1996) Why is Terbinafine so effective in onychomycosis? A pharmacokinetic and scientific rationale. Lamisil (Terbinafine) in onychomycosis: debates old and new, extended abstracts of a satellite symposium held at the Fifth Congress of the European Academy of Dermatology and Venereology, 14 Oct. 1996, Lisbon, Portugal, pp 6–7

  11. Ghate JV, Turner ML, Rudek MA et al. (2001) Drug-induced lupus associated with COL-3: report of three cases. Arch Dermatol 137:471–474

    CAS  PubMed  Google Scholar 

  12. Gupta AK, Porges AJ (1998) Hypersensitivity syndrome reaction to oral terbinafine. Australas J Dermatol 39:171–172

    CAS  PubMed  Google Scholar 

  13. Gupta AK, Lynde CW, Lauzon GJ et al. (1998) Cutaneous adverse effects associated with terbinafine therapy: 10 case reports and a review of the literature. Br J Dermatol 138:529–532

    Article  CAS  PubMed  Google Scholar 

  14. Le Guayadec T, Saint-Blancard P, Bosonnet S et al. (2000) Oral terbinafine-induced plantar pustular psoriasis. Ann Dermatol Venereol 127:279–281

    PubMed  Google Scholar 

  15. Miyagawa S, Okuchi T, Shiomi Y, Sakamoto K (1989) Subacute lupus erythematosus lesions precipitated by griseofulvin. J Am Acad Dermatol 21(2 Pt 2):343–346

    CAS  PubMed  Google Scholar 

  16. Parodi A, Drosera M, Barbieri L, Rebora A (1995) Antihistone antibodies in scleroderma. Dermatology 191:16–18

    CAS  PubMed  Google Scholar 

  17. Richert B, Uhoda I, De La Brassinne M (2001) Hair loss after terbinafine treatment. Br J Dermatol 145:842

    Article  CAS  Google Scholar 

  18. Shapiro M, Li LJ, Miller J (1999) Terbinafine-induced neutropenia. Br J Dermatol 140:1196–1197

    CAS  PubMed  Google Scholar 

  19. Sontheimer RD, Thomas JR, Gilliam JN (1979) Subacute cutaneous lupus erythematosus subset. Arch Dermatol 115:1409–1415

    CAS  PubMed  Google Scholar 

  20. Vivas S, Rodriguez M, Palacio MA et al. (1997) Acute hepatitis associated with terbinafine. Gastroenterol Hepatol 20:456–458

    CAS  PubMed  Google Scholar 

  21. Weedon D (1998) Subacute lupus erythematosus. Skin pathology. Churchill, Livingstone, pp 46–47

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Authors and Affiliations

  1. Hautklinik des Klinikum Darmstadt, Darmstadt

    T. Matthes & M. Hagedorn

  2. Hautklinik des Klinikum Darmstadt, Heidelberger Landstraße 379, 64297 , Darmstadt

    T. Matthes

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  1. T. Matthes
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  2. M. Hagedorn
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Correspondence to T. Matthes.

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Matthes, T., Hagedorn, M. Terbinafin-induzierter subakut-kutaner Lupus erythematodes. Hautarzt 55, 653–657 (2004). https://doi.org/10.1007/s00105-004-0731-6

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  • DOI: https://doi.org/10.1007/s00105-004-0731-6

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