Zusammenfassung
Das orale vernarbende Pemphigoid ist eine chronische bullöse Autoimmundermatose der Mundschleimhaut, die vor allem die Gingiva und Wangenschleimhaut befällt. Die genaue Pathogenese dieser Erkrankung ist jedoch bislang noch nicht eindeutig geklärt, aber es gibt Hinweise, dass es sich unter anderem um eine von T-Lymphozyten vermittelte Erkrankung handelt. Aus diesem Grund führten wir eine topische, immunmodulatorische Behandlung mit Tacrolimus bei 2 Patienten mit lange bestehendem, therapieresistentem oralem vernarbendem Pemphigoid durch. Unter dieser Behandlung konnten innerhalb von 3 Monaten eine komplette Abheilung und unter Fortführung eine anhaltende Remission erzielt werden.
Abstract
Oral cicatricial pemphigoid is a chronic autoimmune blistering disease which affects predominantly the gingiva and the buccal mucosa. The pathogenesis of this disease is still incompletely understood; however, there is compelling evidence that cicatricial pemphigoid might be mediated by T lymphocytes. Therefore, we performed immunomodulatory therapy with topical tacrolimus in patients with long-standing, therapy-resistant oral cicatricial pemphigoid. Following 3 months of treatment, complete healing and ongoing remission could be achieved.
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Assmann, T., Burchardt, T., Becker, J. et al. Topische Immunmodulatoren als Therapieoption für das orale vernarbende Pemphigoid. Hautarzt 55, 390–392 (2004). https://doi.org/10.1007/s00105-004-0714-7
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DOI: https://doi.org/10.1007/s00105-004-0714-7