Zusammenfassung
Bei der am häufigsten in Deutschland angezeigten Berufskrankheit handelt es sich um die BK-Nummer 5101, schwere oder wiederholt rückfällige Hautkrankheiten, die zur Unterlassung aller Tätigkeiten gezwungen haben, die für die Entstehung, die Verschlimmerung oder das Wiederaufleben der Krankheit ursächlich waren oder sein können. Der überwiegende Teil der Berufsdermatosen geht zu Lasten irritativer oder allergischer Kontaktekzeme. Berufsbedingte Soforttypallergien, die sich als Kontakturtikariasyndrom manifestieren, sind vergleichsweise selten, beinhalten jedoch das Risiko schwerer Systembeteiligung. Die klinische Symptomatik, die Arbeitsplatz bezogene Exposition und Gefährdung durch berufsrelevante Typ-I-Allergene sind dargestellt.
Abstract
In Germany the most frequent initial report of occupational disease is due to occupational skin diseases (“Berufskrankheitenanzeige nach Nr. 5101 der Berufskrankheitenverordnung”) defined as “severe or recurrent skin diseases that force the discontinuation of any activity that causes or that could be causing the development, the worsening, or the recurrence of the skin disease”. The majority of these occupational skin diseases consists of irritant and allergic contact dermatitis. In contrast, work place- related Type I allergy (contact urticaria syndrome) is less frequent, but carries the risk of systemic reactions. The clinical manifestations and pattern of exposure to Type I allergens in the work place are described.
Literatur
Arlian LG (2001) Dust mites: update on their allergens and control. Curr Allergy Asthma Rep 1:581–586
Anliker MD, Borelli S, Wüthrich B (2002) Occupational protein contact dermatitis from spices in a butcher: a new presentation of the mugwort-spice syndrome. Contact Dermatitis 46:72–74
Axelsson IG, Johansson SG, Zetterstrom O (1987) Occupational allergy to weeping fig in plant keepers. Allergy 42:161–167
Baur X, Czuppon AB, Rauluk I et al. (1995) A clinical and immunological study on 92 workers occupationally exposed to anhydrids. Int Arch Occup Environ Health 67:395–403
Baur X, Mensing T, Marek W (1996) Klinische und experimentelle Untersuchungen zum Blondiermittelasthma. In: Gesundheitsgefährdung im Friseurhandwerk. Wirtschaftsverlag, Bremerhaven, S 82–86
Baur X, Chen Z, Allmers H (1998) Can a threshold limit value for natural rubber latex airborne allergens be defined? J Allergy Clin Immunol 101:24–27
Bergmann A, Svedberg O, Nilsson E (1995) Contact urticaria with anaphylactic reaction caused by occupational exposure to iridium salt. Contact Dermatitis 32:14–17
Bernstein DI, Jolly A (1999) Current diagnostic methods for diisocyanate induced occupational asthma. Am J Ind Med 36:459–468
Binder M, Mahler V, Hayek B et al. (2001) Molecular and immunological characterization of arginine kinase from the Indianmeal moth, Plodia interpunctella, a novel cross-reactive invertebrate pan-allergen. J Immunol 167:5470–5477
Borghetti C, Magarolas R, Badorrey I et al. (2002) Sensitization and occupational asthma in poultry workers. Med Clin (Barc) 118:251–255
Brauel R, Brauel P, Stresemann E (1995) Kontakturtikaria, Rhinopathie und allergisches Bronchialasthma durch Ammoniumpersulfat in Blondiermittel. Allergologie 18:438–440
Brehler R, Theissen U, Mohr C, Luger T (1997) „Latex-fruit syndrome“: frequency of cross-reacting IgE antibodies. Allergy 52:404–410
Breiteneder H, Scheiner O (1998) Molecular and immunological characteristics of latex allergens. Int Arch Allergy Immunol 116:83–92
Breiteneder H, Ebner C (2001) Atopic allergens of plant foods. Curr Opin Allergy Clin Immunol 1:261–267
Cullen RT, Cherrie B, Soutar CA (1992) Immune responses to colophony, an agent causing occupational asthma. Thorax 47:1050–1055
Dickel H, Kuss O, Blesiuis CR et al. (2001) Occupational skin diseases in Northern Bavaria between 1990 and 1999: a population-based study. Br J Dermatol 145:453–462
Dickel H, Kuss O, Schmidt A et al. (2002) Importance of irritant contact dermatitis in occupational skin disease. Am J Clin Dermatol 3:283–289
Diepgen TL (2002) Hauterkrankungen in der Arbeits- und Sozialmedizin (Editorial). Arbeitsmed Sozialmed Umweltmed 37:4474–4475
Doekes G, Kamminga N, Helwegen L, Heederik D (1999) Occupational IgE sensitization to phytase, a phosphatase derived from Aspergillus niger. Occup Environ Med 56:454–459
Drexler H, Schiel R, Lehnert G (1992) Berufsbedingte obstruktive Atemwegserkrankungen im Friseurhandwerk. Verh Dtsch Ges Arbeitsmed 32:193–196
Drexler H, Schaller KH, Weber A et al. (1993) Skin prick tests with solutions of acid anhydrides in acetone. Int Arch Allergy Immunol 100:251–255
Drexler H, Weber A, Letzel S et al. (1994) Detection and clinical relevance of a type I allergy with occupational exposure to hexahydrophthalic anhydride and methyltetrahydrophthalic anhydride. Int Arch Occup Environ Health 65:279–283
Drexler H, Jonsson BA, Goen T, Nielsen J et al. (2000) Exposure assessment and sensitization in workers exposed to organic acid anhydrides. Int Arch Occup Environ Health 73:228–234
Douwes J, McLean D, Slater T, Pearce N (2001) Asthma and other respiratory symptoms in New Zealand pine processing sawmill workers. Am J Ind Med 39:608–615
Downs AM, Sansom JE (1999) Colophony allergy: a review. Contact Dermatitis 41:305–310
Dutkiewicz J, Skorska C, Dutkiewicz E et al. (2001) Response of sawmill workers to work-related airborne allergens. Ann Agric Environ Med 8:81–90
Estlander T, Kanerva L, Tupasela O et al. (1993) Immediate and delayed allergy to nickel with contact urticaria, rhinitis, asthma and contact dermatitis. Clin Exp Allergy 23:306–310
Estlander T, Jolanki R, Alanko K, Kanerva L (2001) Occupational allergic contact dermatitis caused by wood dusts. Contact Dermatitis 44:213–217
Fernandez-Rivas M, Perez-Carral C, Senent CJ (1997) Occupational asthma and rhinitis caused by ash (Fraxinus excelsior) wood dust. Allergy 52:196–199
Ferrer A, Maranon F, Casanovas M, Fernandez-Caldas E (2001) Asthma from inhalation of Triplochiton scleroxylon (Samba) wood dust. J Investig Allergol Clin Immunol 11:199–203
Forck G (1968) Vorkommen und Persistenz von Persulfatallergien. Berufsdermatosen 16:84–92
Gellrich S, Zuberbier T (2001) Innenraumallergene. Hautarzt 52:915–926
Gordon S, Jones MG, Tee RD et al. (1997) Review: the biochemistry of common aeroallergens. Clin Exp Allergy 27:714–715
Groenewoud GC, de Graaf in ‚t Veld C, Van Oorschot-van Nes AJ et al. (2002) Prevalence of sensitization to the predatory mite Amblyseius cucumeris as a new occupational allergen in horticulture. Allergy 57:614–619
Guerra L, Tosti E, Bardazzi F et al. (1992) Contact dermatitis in hairdressers: the Italien Experience. Contact Derm 26:101–107
Guin JD (2000) Occupational contact dermatitis to Plants. In: Kanerva L, Elsner P, Wahlberg JE, Maibach HJ (eds) Handbook of occupational dermatology. Springer, Berlin Heidelberg New York Tokyo, p 748
Hartmann A, Wüthrich B, Bolognini G (1982) Occupation-related lung diseases in hard metal production and manufacturing. An allergic process? Schweiz Med Wochenschr 112:1137–1141
Heese A, Peters KP, Koch HU, Hornstein OP (1995) Allergy against latex gloves. Allergologie 18:358–365
Helgesen AL, Austad J (1997) Contact urticaria from aluminium and nickel in the same patient. Contact Dermatitis 37:303–304
Hjorth N, Roed-Petersen J (1976) Occupational protein contact dermatitis in food handlers. Contact Dermatitis 2:28–42
Kanerva L, Tuppurainen M, Keskinen H (1998) Contact urticaria caused by obeche wood (Triplochiton scleroxylon). Contact Dermatitis 38:170–171
Kanerva L, Susitaival P (1996) Cow hair: the most common cause of occupational contact urticaria in Finland. Contact Dermatitis 35:309–310
Kassenärztliche Bundesvereinigung (2001) Mitteilungen und Bekanntmachungen; Vertrag gem. § 34 Abs. 3 SGB VII zwischen dem Hauptverband der gewerblichen Berufsgenossenschaften, dem Bundesverband der landwirtschaftlichen Berufsgenossenschaften, dem Bundesverband der Unfallkassen einerseits und der Kassenärztlichen Bundesvereinigung andererseits über die Durchführung der Heilbehandlung, die Vergütung der Ärzte sowie die Art und Weise der Abrechnung der ärztlichen Leistungen; gültig ab 1. Mai 2001; Sonderbeilage Deutsches Ärzteblatt 4/2001 vom 26.1.2001
Kellett JK, Beck MH (1985) Ammonium persulphate sensitivity in hairdressers. Contact Dermatitis 13:26–28
Kim YK, Kim YY (2002) Spider-mite allergy and asthma in fruit growers. Curr Opin Allergy Clin Immunol 2:103–107
Kronqvist M, Johansson E, Pershagen G et al. (1999) Increasing prevalence of asthma over 12 years among dairy farmers on Gotland, Sweden: storage mites remain dominant allergens. Clin Exp Allergy 29:35–41
Leino T, Tammilehto L, Hytonen M et al. (1998) Occupational skin and respiratory diseases among hairdressers. Scand J Work Environ Health 24:398–406
Leitner A, Jensen-Jarolim E, Grimm R et al. (1998) Allergens in pepper and paprika. Immunologic investigation of the celery-birch-mugwort-spice syndrome. Allergy 53:36–41
Mahler V, Diepgen TL, Heese A, Peters KP (1998) Protein contact dermatitis due to cow dander. Contact Dermatitis 38:47–48
Mahler V, Fischer S, Fuchs T et al. (2000) Prevention of latex allergy by selection of low-allergen gloves. Clin Exp Allergy 30:509–520
Malo JL, Cartier A, Desjardins A et al. (1995) Occupational asthma caused by oak wood dust. Chest 108:856–858
Mensing T, Marek W, Raulf-Heimsoth M, Baur X (1995) Blondiermittelbestandteile als Auslöser einer bronchialen Überempfindlichkeit—Untersuchungen an einem Modell für berufsbedingte Lungenschädigungen. Pneumologie 7:418–427
Merget R, Sander I, Raulf-Heimsoth M, Baur X (2001) Baker’s asthma due to xylanase and cellulase without sensitization to alpha-amylase and only weak sensitization to flour. Int Arch Allergy Immunol 124:502–505
Merget R, Kulzer R, Kniffka A et al. (2002) Platinum concentrations in sera of catalyst production workers are not predictive of platinum salt allergy. Int J Hyg Environ Health 205:347–351
Monteseirin J, Perez-Formoso JL, Sanchez-Hernandez MC et al. (2002) Occupational contact dermatitis to dill. Allergy 57:866–867
Murdoch RD, Pepys J (1987) Platinum group metal sensitivity: Reaction to platinum group metal salts in platinum halide salt-sensitive workers. Ann Allergy 59:464–469
Musken H, Franz JT, Wahl R et al. (2000) Sensitization to different mite species in German farmers: clinical aspects. J Investig Allergol Clin Immunol 10:346–351
Nahm DH, Park JW, Hong CS (1996) Occupational asthma due to deer dander. Ann Allergy Asthma Immunol 76:423–426
Nielsen J, Welinder HE, Horstmann V, Skerfving S (1992) Allergy to methyltetrahydrophthalic anhydrid in epoxy resin workers. Br J Ind Med 49:769–775
Nielsen J, Welinder H, Bensryd I et al. (1994) Symptoms and immunologic markers induced by exposure to methyltetrahydrophthalic anhydride. Allergy 49:281–286
Obata H, Dittrick M, Chan H, Chan-Yeung M (2000) Occupational asthma due to exposure to African cherry (Makore) wood dust. Intern Med 39:947–949
Osterman K, Zetterstrom O, Jadassohn SG (1982) Coffee workers allergy. Allergy 37:315–322
Palmer K, Crane G (1997) Respiratory disease in workers exposed to colophony solder flux fumes: continuing health concerns. Occup Med (Lond) 47:491–496
Parsons JF, Goodwin BFJ, Safford RJ (1979) Studies on the action of histamine release by persulphates. Food Chem Toxicol 17:129–136
Peters KP, Frosch PJ, Uter W et al. (1994) Typ-IV-Allergien auf Friseurstoffe. Dermatosen 42:50–57
Pichler C (2001) House dust mites and storage compartment mites as allergy inducers. Ther Umsch 58:292–296
Przybilla B, Ruëff F (1996) Zur gesundheitlichen Gefährdung durch die Allergene vom Soforttyp gegenüber Naturlatex. Allergo J 5:185–192
Quirce S, Hinojosa M, Maranon F et al. (2000) Identification of obeche wood (Triplochiton scleroxylon) allergens associated with occupational asthma. J Allergy Clin Immunol 106:400–401
Raulf-Heimsoth M, Baur X (1999) Pathologic mechanisms of diseases caused by isocyanates—review of current knowledge. Pneumologie 53:143–149
Sander I, Raulf-Heimsoth M, Siethoff C et al. (1998) Allergy ro Apergillus-derived enzymes in the baking industry: Identification of ß-xylosidase from aspergillus niger as a new allergen (Asp n 14). J Allergy Clin Immunol 102:256–264
Sander I, Flagge A, Merget R et al. (2001) Identification of wheat flour allergens by means of 2-dimensional immunoblotting. J Allergy Clin Immunol 107:907–913
Schmid K, Broding HC, Niklas D, Drexler H (2002) Latex sensitization in dental students using powder-free gloves low in latex protein: a cross-sectional study. Contact Derm 47:103–108
Schultze-Werninghaus G, Roesch A, Wilhelms OH et al. (1978) Bronchial asthma due to occupation allergy of immediate type (I) to platinum salts (author’s transl). Dtsch Med Wochenschr 103:972–975
Skorska C, Krysinska-Traczyk E, Milanowski J et al. (2002) Response of furniture factory workers to work-related airborne allergens. Ann Agric Environ Med 9:91–97
Smith JD, Odom RB, Maibach HI (1975) Contact urticaria from cobalt chloride. Arch Dermatol 111:1610–1611
Spiewak R, Dutkiewicz J, Skorska C (2000) Detection of specific IgE as a screening tool for cow and swine breeders‘ occupational allergic dermatoses. Ann Agric Environ Med 7:145–147
Sutthipisal N, McFadden JP, Cronin E (1993) Sensitization in atopic and non-atopic hairdressers with hand eczema. Contact Dermatitis 29:206–209
Susitaival P, Husman L, Hollmen A et al. (1995) Hand eczema in Finnish farmers. A questionnaire-based clinical study. Contact Dermatitis 32:150–155
Tosti A, Melino M, Veronesi S (1987) Contact urticaria to tobacco. Contact Dermatitis 16:225–226
van der Heide S, Niemeijer NR, Hovenga H et al. (1998) Prevalence of sensitization to the storage mites Acarus siro, Tyrophagus putrescentiae, and Lepidoglyphus destructor in allergic patients with different degrees of sensitization to the house-dust mite Dermatophagoides pteronyssinus. Allergy 53:426–430
van Hage-Hamsten M, Johansson E (1998) Clinical and immunologic aspects of storage mite allergy. Allergy 53 [Suppl 48]:49–53
van Tongeren MJA, Barker RD, Gardiner K et al. (1998) Retrospective exposure assessment for a cohort study into respiratory effects of acid anhydrids. Occup Environ Med 55:692–696
Venables KM (1989) Low molecular weight chemicals, hypersensivity and direct toxicity: the acid anhydrids. Br J Ind Med 46:222–232
von Krogh G, Maibach HI (1981) The contact urticaria syndrome—an updated review. J Am Acad Dermatol 5:328–342
Wagner S, Breiteneder H (2001) The latex-fruit syndrome. Biochem Soc Trans 30:935–940
Wallenstein G, Wagner E, Schönreich R (1992) Polyvalente Allergie (Asthma, Ekzem) durch Friseurchemikalien-Kasuistik. Allergologie15:69
Welinder H, Nielsen J, Gustavsson C et al. (1990) Specific antibodies to methyltetrahydrophthalic anhydride in exposed workers. Clin Exp Allergy 20:639–645
Werfel S, Rueff F, Przybilla B (2001) Anaphylactic reaction to Ficus benjamina (weeping fig). Hautarzt 52:935–937
Wilhelmsson B, Jernudd Y, Ripe E, Holmberg K (1985) Nasal hypersensitivity in wood furniture workers. Rhinology 23:297–302
Wrbitzky R, Drexler H, Letzel S (1995) Early reaction type allergies and diseases of the respiratory passages in employees from persulphate production. Int Arch Occup Environ Health 67:413–417
Wüthrich B, Baur X (1990) Baking ingredients, especially alpha-amylase, as occupational inhalation allergens in the baking industry. Schweiz Med Wochenschr 120:446–450
Yawalkar N, Helbing A, Pichler CE et al. (1999) T cell involvement in persulfate triggered occupational contact dermatitis and asthma. Ann Allergy Asthma Immunol 82:401–404
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Mahler, V., Drexler, H. Berufsdermatologisch relevante Typ-I-Allergien. Hautarzt 55, 34–41 (2004). https://doi.org/10.1007/s00105-003-0651-x
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DOI: https://doi.org/10.1007/s00105-003-0651-x