Skip to main content
SpringerLink
Log in

Erfolgreiche Lokaltherapie einer kutanen Sarkoidose mit Tacrolimus

  • Kasuistik
  • Published:
Der Hautarzt Aims and scope Submit manuscript

Zusammenfassung

Eine 56-jährige Patientin mit kutaner Sarkoidose im Gesichtsbereich wurde zunächst erfolglos mit Fumarsäureestern und Doxycyclin behandelt. Unter einer topischen Therapie mit Tacrolimus kam es innerhalb von 3 Monaten zu einer klinisch und histologisch fast vollständigen Abheilung, die nach jetzt 4 Monaten nach Beendigung der Therapie weiter anhält.

Abstract

A 56-year old female patient with cutaneous sarcoidosis in the face was treated with fumaric acid esters and doxycycline without any effect. Topical tacrolimus led clinically and histologically to a nearly complete remission within three months, which continued after 4 months of follow-up.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Abb. 1a, b
Abb. 2a, b

Literatur

  1. Agostini C, Semenzato G (1998) Cytokines in sarcoidosis. Semin Respir Infect 13:184–196

    CAS  PubMed  Google Scholar 

  2. Alaiti S, Kang S, Fiedler VC et al. (1998) Tacrolimus (FK506) ointment for atopic dermatitis: a phase I study in adults and children. J Am Acad Dermatol 38:69–76

    CAS  PubMed  Google Scholar 

  3. Bachelez H, Senet P, Cadranel J et al. (2001) The use of tetracyclines for the treatment of sarcoidosis. Arch Dermatol 137:69–73

    CAS  Google Scholar 

  4. Brechtel B, Haas N, Henz BM, Kolde G (1996) Allopurinol: a therapeutic alternative for disseminated cutaneous sarcoidosis. Br J Dermatol 135:307–309

    CAS  PubMed  Google Scholar 

  5. English JC III, Patel PJ, Greer KE (2001) Sarcoidosis. J Am Acad Dermatol 44:725–743

    Article  PubMed  Google Scholar 

  6. Frizzell B, Stith M, Jenrette J (2002) Management of treatment-resistant cutaneous sarcoidosis with radiation. Am J Clin Oncol 25:573–575

    Article  PubMed  Google Scholar 

  7. Graefe T, Konrad H, Barta U et al. (2001) Successful ultraviolet A1 treatment of cutaneous sarcoidosis. Br J Dermatol 145:354–355

    Article  CAS  PubMed  Google Scholar 

  8. Hoch O, Muller S, Buttner G, Mensing H (2001) Thalidomide in the treatment of cutaneous and systemic sarcoidosis. Hautarzt 52:962–965

    Article  CAS  PubMed  Google Scholar 

  9. Homey B, Assmann T, Vohr HWet al. (1998) Topical FK506 suppresses cytokine and costimulatory molecule expression in epidermal and local draining lymph node cells during primary skin immune responses. J Immunol 160:5331–5340

    CAS  PubMed  Google Scholar 

  10. Jones E, Callen JP (1990) Hydroxychloroquine is effective therapy for control of cutaneous sarcoidal granulomas. J Am Acad Dermatol 23:487–489

    CAS  PubMed  Google Scholar 

  11. Karrer S, Abels C, Wimmershoff MB et al. (2002) Successful treatment of cutaneous sarcoidosis using topical photodynamic therapy. Arch Dermatol 138:581–584

    PubMed  Google Scholar 

  12. Katoh N, Mihara H, Yasuno H (2002) Cutaneous sarcoidosis successfully treated with topical tacrolimus. Br J Dermatol 147:154–156

    Article  CAS  PubMed  Google Scholar 

  13. Liedtka JE (1996) Intralesional chloroquine for the treatment of cutaneous sarcoidosis. Int J Dermatol 35:682–683

    CAS  Google Scholar 

  14. Mahnke N, Medve-Koenigs K, Megahed M, Neumann NJ (2003) Medium-dose-UV-A1-Phototherapie. Erfolgreiche Behandlung einer kutanen Sarkoidose. Hautarzt 54:364–366

    CAS  PubMed  Google Scholar 

  15. Mallbris L, Ljungberg A, Hedblad MA et al. (2003) Progressive cutaneous sarcoidosis responding to anti-tumor necrosis factor-alpha therapy. J Am Acad Dermatol 48:290–293

    Article  PubMed  Google Scholar 

  16. Nowack U, Gambichler T, Hanefeld C et al. (2002) Successful treatment of recalcitrant cutaneous sarcoidosis with fumaric acid esters. BMC Dermatol 2:15

    Article  PubMed  Google Scholar 

  17. Panhans-Gross A, Novak N, Kraft S, Bieber T (2001) Human epidermal Langerhans‘ cells are targets for the immunosuppressive macrolide tacrolimus (FK506). J Allergy Clin Immunol 107:345–352

    Article  CAS  PubMed  Google Scholar 

  18. Pfau A, Stolz W, Karrer S et al. (1998) Allopurinol in treatment of cutaneous sarcoidosis. Hautarzt 49:216–218

    Article  CAS  PubMed  Google Scholar 

  19. Rousseau L, Beylot-Barry M, Doutre MS, Beylot C (1998) Cutaneous sarcoidosis successfully treated with low doses of thalidomide. Arch Dermatol 134:1045–1046

    Article  CAS  PubMed  Google Scholar 

  20. Ruzicka T, Bieber T, Schopf E et al. (1997) A short-term trial of tacrolimus ointment for atopic dermatitis. European Tacrolimus Multicenter Atopic Dermatitis Study Group. N Engl J Med 337:816–821

    Article  CAS  PubMed  Google Scholar 

  21. Sawada S, Suzuki G, Kawase Y, Takaku F (1987) Novel immunosuppressive agent, FK506. In vitro effects on the cloned T cell activation. J Immunol 139:1797–1803

    CAS  PubMed  Google Scholar 

  22. Schmidt RJ, Bender FH, Chang WW, Teba L (1999) Sarcoidosis after renal transplantation. Transplantation 68:1420–1423

    CAS  PubMed  Google Scholar 

  23. Siltzbach LE, Teirstein AS (1964) Chloroquine therapy in 43 patients with intrathoracic and cutaneous sarcoidosis. Acta Med Scand Suppl 425:302–308

    CAS  PubMed  Google Scholar 

  24. Spiteri MA, Taylor SJ (1985) Retinoids in the treatment of cutaneous sarcoidosis. Arch Dermatol 121:1486

    Article  CAS  Google Scholar 

  25. Veien NK, Brodthagen H (1977) Cutaneous sarcoidosis treated with methotrexate. Br J Dermatol 97:213–216

    CAS  PubMed  Google Scholar 

  26. Waldinger TP, Ellis CN, Quint K, Voorhees JJ (1983) Treatment of cutaneous sarcoidosis with isotretinoin. Arch Dermatol 119:1003–1005

    Article  CAS  PubMed  Google Scholar 

  27. Webster GF, Razsi LK, Sanchez M, Shupack JL (1991) Weekly low-dose methotrexate therapy for cutaneous sarcoidosis. J Am Acad Dermatol 24:451–454

    CAS  PubMed  Google Scholar 

  28. Wollenberg A, Sharma S, von Bubnoff D et al. (2001) Topical tacrolimus (FK506) leads to profound phenotypic and functional alterations of epidermal antigen-presenting dendritic cells in atopic dermatitis. J Allergy Clin Immunol 107:519–525

    Article  CAS  PubMed  Google Scholar 

  29. Zic JA, Horowitz DH, Arzubiaga C, King LE Jr (1991) Treatment of cutaneous sarcoidosis with chloroquine. Review of the literature. Arch Dermatol 127:1034–1040

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Klinik und Poliklinik für Dermatologie und Venerologie der Medizinischen Hochschule Hannover, Hannover

    R. Gutzmer, B. Völker, A. Kapp & T. Werfel

  2. Klinik und Poliklinik für Dermatologie und Venerologie, Medizinische Hochschule, Ricklinger Straße 5, 30449 , Hannover

    R. Gutzmer

Authors
  1. R. Gutzmer
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. B. Völker
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. A. Kapp
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. T. Werfel
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to R. Gutzmer.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Gutzmer, R., Völker, B., Kapp, A. et al. Erfolgreiche Lokaltherapie einer kutanen Sarkoidose mit Tacrolimus. Hautarzt 54, 1193–1197 (2003). https://doi.org/10.1007/s00105-003-0626-y

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00105-003-0626-y

Schlüsselwörter

Keywords

Search

Navigation