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Mycophenolatmofetil als effektive Therapieoption bei vernarbendem Pemphigoid

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Zusammenfassung

Wir berichten über eine 70-jährige Patientin mit einem vernarbenden Pemphigoid der Haut und Schleimhäute, die mit einer Kombinationstherapie aus Mycophenolatmofetil und Prednisolon behandelt wurde. Hierunter kam es zu einer vollständigen Abheilung der Läsionen, und unerwünschte Nebenwirkungen wurden nicht beobachtet.

Abstract

A 70-year-old woman with cicatricial pemphigoid of the skin and oral mucosa was treated with a combination of mycophenolate mofetil and prednisolone. This treatment led to complete remission of all lesions, and no side effects were observed.

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Literatur

  1. Ahmed AR, Hombal SM (1986) Cicatricial pemphigoid. Int J Dermatol 25:90–96

    CAS  PubMed  Google Scholar 

  2. Bhol KC, Goss L, Kumari S et al. (2001) Autoantibodies to human alpha6 integrin in patients with oral pemphigoid. J Dent Res 80:1711–1715

    CAS  PubMed  Google Scholar 

  3. Boehm M, Beissert S, Schwarz T et al. (1997) Bullous pemphigoid treated with mycophenolate mofetil. Lancet 349:541

    Article  PubMed  Google Scholar 

  4. Chan LS, Majmudar AA, Tran HH et al. (1997) Laminin-6 and laminin-5 are recognized by autoantibodies in a subset of cicatricial pemphigoid. J Invest Dermatol 108:848–853

    CAS  PubMed  Google Scholar 

  5. Egan CA, Lazarova Z, Darling TN et al. (2003) Anti-epiligrin cicatricial pemphigoid.Clinical findings, immunopathogenesis and significant associations. Medicine 82:177–186

    Article  PubMed  Google Scholar 

  6. Enk AH, Knop J (1997) Treatment of pemphigus vulgaris with mycophenolate mofetil. Lancet 350:494

    CAS  PubMed  Google Scholar 

  7. European Mycophenolate Mofetil Cooperative Study Group (1995) Placebo-controlled study of mycophenolate mofetil combined with cyclosporin and corticosteroids for prevention of acute rejection. Lancet 345:1321–1325

    PubMed  Google Scholar 

  8. Fleming TE, Korman NJ (2000) Cicatricial pemphigoid. J Am Acad Dermatol 43:571–591

    Google Scholar 

  9. Foster CS, Ahmed AR (1999) Intravenous immunoglobulin therapy for ocular cicatricial pemphigoid: a preliminary study. Ophthalmology 106:2136–2143

    CAS  PubMed  Google Scholar 

  10. Hashimoto Y, Suga Y, Yoshiike T et al. (2000) A case of antiepiligrin cicatricial pemphigoid successfully treated by plasmapheresis. Dermatology 201:58–60

    Article  CAS  PubMed  Google Scholar 

  11. Labib RS, Anhalt GJ, Patel HP et al. (1986) Molecular heterogeneity of the bullous pemphigoid antigens as detected by immunoblotting. J Immunol 136:1231–1235

    CAS  PubMed  Google Scholar 

  12. Lazor JB, Varvares MA, Montgomery WW et al. (1996) Management of airway obstruction in cicatricial pemphigoid. Laryngoscope 106:1014–1017

    CAS  PubMed  Google Scholar 

  13. Leverkus M, Bhol K, Hirako J et al. (2001) Cicatricial pemphigoid with circulating autoantibodies to beta4 integrin, bullous pemphigoid 180 and bullous pemphigoid 230. Br J Dermatol 145: 998–1004

    Article  CAS  PubMed  Google Scholar 

  14. Lipsky J (1996) Mycophenolate mofetil. Lancet 348:1357–1359

    CAS  PubMed  Google Scholar 

  15. Marren P, Wojnarowska F, Venning V et al. (1993) Vulvar involvement in autoimmune bullous diseases. J Reprod Med 38:101–107

    CAS  PubMed  Google Scholar 

  16. Megahed M (in press) Histopathology of blistering diseases with clinical, electron microscopic, immunological, and molecular biological correlations. Springer, Berlin Heidelberg New York Tokyo

  17. Megahed M, Schmiedeberg S, Becker J et al. (2001) Treatment of cicatricial pemphigoid with mycophenolate mofetil as a steroid-sparing agent. J Am Acad Dermatol 45:256–259

    CAS  PubMed  Google Scholar 

  18. Neumann R, Tauber J, Foster CS (1991) Remission and recurrence after withdrawal of therapy for ocular cicatricial pemphigoid. Ophthalmology 98:858–862

    CAS  PubMed  Google Scholar 

  19. Nousari HC, Sragovich A, Kimjai-Asadi A et al. (1999) Mycophenolate mofetil in autoimmune and inflammatory skin disorders. J Am Acad Dermatol 40:265–268

    CAS  PubMed  Google Scholar 

  20. Olivry T, Dunston SM, Schachter M et al. (2001) A spontaneous canine model of mucous membrane (cicatricial) pemphigoid, an autoimmune blistering disease affecting mucosae and mucocutaneous junctions. J Autoimmun 16:411–421

    Article  CAS  PubMed  Google Scholar 

  21. Reis A, Reinhard T, Sundmacher R et al. (1998) Mycophenolatmofetil (CellCept) bei okulären immunologischen Störungen. Klin Monatsbl Augenheilkd 213:257–261

    CAS  PubMed  Google Scholar 

  22. Tyagi S, Bhol K, Natarajan K et al. (1996) Ocular cicatricial pemphigoid antigen: partial sequence and biochemical characterization. Proc Natl Acad Sci USA 93:14714–14719

    Article  CAS  PubMed  Google Scholar 

  23. Yancey KB, Egan CA (2000) Pemphigoid: clinical, histologic, immunopathologic, and therapeutic considerations. JAMA 284:350–356

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Hautklinik, Universitätsklinikum Düsseldorf, Düsseldorf

    I. Elser, D. Selimovic, T. Ruzicka, A. Kuhn &  M. Megahed

  2. Hautklinik, Universitätsklinikum Düsseldorf, Düsseldorf

    M. Megahed

Authors
  1. I. Elser
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  2. D. Selimovic
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  3. T. Ruzicka
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  4. A. Kuhn
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  5. M. Megahed
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Corresponding author

Correspondence to M. Megahed.

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Elser, I., Selimovic, D., Ruzicka, T. et al. Mycophenolatmofetil als effektive Therapieoption bei vernarbendem Pemphigoid. Hautarzt 54, 981–984 (2003). https://doi.org/10.1007/s00105-003-0595-1

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  • DOI: https://doi.org/10.1007/s00105-003-0595-1

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