Zusammenfassung
Wir berichten über einen 63-jährigen Patienten mit einem ausgeprägten perianalen und palmaren Ekzem, als dessen Ursache eine Kontaktsensibilisierung gegen Iodpropinylbutylcarbamat in feuchtem Toilettenpapier nachgewiesen werden konnte. Spättypsensibilisierungen gegen diese Substanz sind insofern von besonderer Relevanz, als dass Iodpropinylbutylcarbamat seit 1996 zunehmend als Biozid in Kosmetikartikeln (unter anderem in Feuchtwischtüchern) eingesetzt wird und dabei die als häufige Sensibilisatoren bekannten Isothiazolinone und das Methyldibromoglutaronitril verdrängt. Das erhebliche Sensibilisierungspotenzial diverser Konservierungsstoffe ist für die Kosmetikindustrie ein permanentes Problem, da allergologisch vollständig unbedenkliche Biozide derzeit nicht verfügbar sind, bestimmte Produktgruppen—wie etwa Feuchttücher—in Mehrwegpackungen aber eine profunde Konservierung erfordern.
Abstract
A 63-year old man developed severe perianal and palmar contact dermatitis caused by sensitization to iodopropynyl butylcarbamate in moist sanitary wipes. Iodopropynyl butylcarbamate is increasingly employed as preservative in common cosmetic formulations and moist sanitary wipes as substitute for the previously frequently used sensitizers isothiazolinones and methyldibromoglutaronitrile. The allergic potential of diverse preservatives is a serious problem for the cosmetic industry, since truly hypoallergenic preservatives are not available but products such as moist sanitary wipes in large packages definitely require some form of protection.
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Schöllnast, R., Kränke, B. & Aberer, W. Anal- und Palmarekzem durch Iodpropinylbutylcarbamat in feuchtem Toilettenpapier. Hautarzt 54, 970–974 (2003). https://doi.org/10.1007/s00105-003-0585-3
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DOI: https://doi.org/10.1007/s00105-003-0585-3