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Großzellig anaplastisches Lymphom und Keratoakanthom

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Zusammenfassung

CD30-positive lymphoproliferative Veränderungen wie das großzellig anaplastische Lymphom (ALCL) oder die lymphomatoide Papulose (LyP) sind häufig mit einer pseudoepitheliomatösen Hyperplasie assoziiert. Die Entwicklung von epithelialen Tumoren bei ALCL oder LyP ist sehr selten, das Auftreten einzelner CD30-positiver Lymphozyten in epithelialen Tumoren wie Basalzellkarzinomen oder Keratoakanthomen hingegen ein häufig zu beobachtendes Phänomen. Nachfolgend wird der Fall eines 66-jährigen Patienten dargestellt, bei dem in einem plaqueförmigen Infiltrat eines CD30-positiven ALCL das rasche Wachstum eines verhornenden Plattenepitheltumors beobachtet wurde. Dieser Tumor wurde aufgrund der Klinik und der Histologie als Keratoakanthom eingeordnet. Von einer unmittelbaren Interaktion zwischen CD30-positiven Lymphozyten und Epithelzellen kann ausgegangen werden.

Abstract

In CD30 positive lymphoproliferative disorders, e.g. anaplastic large cell lymphoma (ALCL) and lymphomatoid papulosis (LyP), pseudoepitheliomatous hyperplasia may occur in up to 50 percent of the cases. Epithelial tumors are rarely associated with ALCL or LyP, but the presence of single CD30 positive cells among the infiltrate accompanying epithelial tumors such as basal cell carcinomas and keratoacanthomas is well known. A 66-year-old man developed within a plaque of ALCL a rapidly growing epithelial tumor which we classified according to the clinical and histological features as keratoacanthoma. This case underlines the intimate interaction between CD30 positive lymphocytes and epithelial cells.

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Authors and Affiliations

  1. Hautklinik, Städtisches Krankenhaus Hildesheim

    M. Tronnier

  2. Institut für Pathologie, Universitätsklinikum Schleswig-Holstein, Campus Lübeck

    H. Merz

  3. Hautklinik, Städtisches Krankenhaus GmbH, Weinberg 1, 31134 , Hildesheim

    M. Tronnier

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  1. M. Tronnier
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  2. H. Merz
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Correspondence to M. Tronnier.

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Tronnier, M., Merz, H. Großzellig anaplastisches Lymphom und Keratoakanthom. Hautarzt 55, 182–185 (2004). https://doi.org/10.1007/s00105-003-0570-x

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  • DOI: https://doi.org/10.1007/s00105-003-0570-x

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