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Aktuelle Aspekte der topischen Psoriasisbehandlung

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Zusammenfassung

Neben den auch heute noch gebräuchlichen und häufig eingesetzten klassischen äußerlichen Behandlungskonzepten mit Dithranol oder Kortikosteroiden haben die topisch anwendbaren Vitamin-D3-Präparate oder Vitamin-D3-Analoga sowie topische Retinoide breite Verwendung gefunden. Kombinationen dieser neueren topischen Antipsoriatika sowohl untereinander als auch mit UV-Licht oder mit systemisch wirksamen Medikamenten haben oft eine größere therapeutische Effizienz als entsprechende Monotherapien. Besonders häufig wird in der Praxis bei Patienten mit leichter bis mittelschwerer Psoriasis die Kombination von Calcipotriol mit topischen Kortikosteroiden eingesetzt, die 2-mal täglich sequenziell, neuerdings auch 1-mal täglich in fixer Kombination angewendet werden kann. Auch bei schweren Formen der Psoriasis, die einer systemischen Behandlung bedürfen, ermöglicht eine zusätzliche wirksame topische Therapie ein besseres Langzeitmanagement.

Abstract

Classical topical treatment regimens in psoriasis including dithranol and corticosteroids are widely used and have been supplemented in recent years by topical vitamin D preparations, by vitamin D analogues and topical retinoids.The combination of these preparations with each other, with UV light or with systemic drugs often lead to improved effectiveness and tolerability when compared with the respective monotherapy. In private offices, the combination of calcipotriol with various corticosteroids is very commonly prescribed for patients with mild to moderate psoriasis. This combination can be sequentially applied twice daily or -- in a newly introduced fixed preparation -- once daily. In severe psoriasis requiring systemic treatment a concomitant effective topical treatment regimen can greatly improve the overall longtime management in affected patients.

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Authors and Affiliations

  1. Klinik und Poliklinik für Dermatologie, Universitätsklinikum Carl Gustav Carus Dresden an der Technischen Universität Dresden

    R. Aschoff, G. Wozel & M. Meurer

  2. Klinik und Poliklinik für Dermatologie, Universitätsklinikum Carl Gustav Carus Dresden an der Technischen Universität Dresden, Fetscherstraße 74, 01307 , Dresden

    R. Aschoff

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  1. R. Aschoff
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  2. G. Wozel
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  3. M. Meurer
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Aschoff, R., Wozel, G. & Meurer, M. Aktuelle Aspekte der topischen Psoriasisbehandlung. Hautarzt 54, 237–241 (2003). https://doi.org/10.1007/s00105-003-0498-1

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