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Triggermechanismen der Psoriasis

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Zusammenfassung

In der Definition der psoriatischen Erkrankung wurde früher und wird heute umso mehr auf die notwendige genetische Prädisposition des Erkrankten sowie auf die Abhängigkeit des Erkrankungsverlaufes von Umweltfaktoren hingewiesen. Die Psoriasis ist eine irritable Dermatose, d. h. sie kann durch unterschiedliche endogene und exogene Triggermechanismen sowohl zur Exazerbation als auch zur Manifestation gebracht werden. Das Wissen um Provokationsfaktoren ist wichtig für den klinischen Alltag. Diese Übersicht konzentriert sich auf die wichtigsten Triggerfaktoren (Infekte/Superantigene, Verletzungen/Köbner-Phänomen, Stress/Neuropeptide, Rauchen, Alkohol, Medikamente) und informiert über die derzeit vorliegenden Daten zur Einordnung dieser Triggerfaktoren in ein ätiopathologisches Konzept.

Abstract

Psoriasis is often defined as a disease in which there is a genetic predisposition but environmental stimuli ("trigger factors") are also necessary for clinical expression. Various endogenous and exogenous factors can either induce or exacerbate the clinical features. Knowledge of these factors is of primary importance in clinical practice. This review focuses on the most common environmental trigger factors (infection/superantigens, injury/Köbner phenomenon, stress/neuropeptides, smoking and alcohol) and evaluates the clinical and experimental concepts to explain "environmentally" triggered psoriasis.

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Authors and Affiliations

  1. Haut- und Allergieklinik, Klinikum Stadt Hanau

    H. M. Ockenfels

  2. Haut- und Allergieklinik, Klinikum Stadt Hanau, Leimenstraße 20, 63450 , Hanau

    H. M. Ockenfels

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  1. H. M. Ockenfels
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Correspondence to H. M. Ockenfels.

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Diese Übersichtsarbeit ist Herrn Professor Dr. med. Manfred Goos mit besten Wünschen zum 65. Geburtstag gewidmet.

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Ockenfels, H.M. Triggermechanismen der Psoriasis. Hautarzt 54, 215–223 (2003). https://doi.org/10.1007/s00105-003-0494-5

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