Zusammenfassung
In den letzten Jahren hat ein Paradigmenwechsel im Verständnis der Pathogenese der Psoriasis stattgefunden. Psoriasis wird nun als eine in weiten Bereichen T-Zell-induzierte Hautentzündung angesehen. Genetische Prädisposition und mikrobielle Umwelt wirken bei der Auslösung einer antigenspezifischen T-Zell-vermittelten Immunreaktion in der Haut zusammen, welche nach ihrem Ausbruch oft lebenslang persistiert. Der Phänotyp der psoriatischen Entzündung wird hierbei durch die funktionelle Differenzierung der pathogenen T-Zellen bestimmt. Durch den Fortschritt im Verständnis der Psoriasispathogenese wurden T-Zellen und ihre Zytokine zu Ansatzpunkten für die Entwicklung kausaler Behandlungsansätze, welche die Psoriasistherapie in naher Zukunft entscheidend verändern werden.
Abstract
During recent years the understanding of psoriasis pathogenesis has changed essentially. Psoriasis is now considered as a T cell mediated inflammation of the skin. Genetic predisposition and microbial environment cooperate in the induction of an antigen-specific T cell mediated immune response which may persist lifelong. The phenotype of the psoriatic inflammation is determined by the particular functional differentiation of the pathogenic T cells. The progress in understanding the pathogenesis of psoriasis has identified T cells and T cell-derived cytokines as targets for causal treatment approaches that in the near future will change psoriasis therapy considerably.
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Prinz, J.C. Neueste Aspekte in der Pathogenese der Psoriasis. Hautarzt 54, 209–214 (2003). https://doi.org/10.1007/s00105-003-0490-9
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DOI: https://doi.org/10.1007/s00105-003-0490-9