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Bullöse Autoimmundermatosen

Teil 2: Pathogenese

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Literatur

  1. Amagai M, Klaus-Kovtun V, Stanley JR (1991) Auto-Ab against a novel epithelial cadherin in pemphigus vulgaris, a disease of cell adhesion. Cell 67:869–877

    Article  CAS  PubMed  Google Scholar 

  2. Amagai M, Tsunoda K, Suzuki H, Nishifuji K, Koyasu S, Nishikawa T (2000) Use of autoantigenknockout mice in developing an active autoimmune disease model for pemphigus. J Clin Invest 105:625–631

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  3. Anhalt GJ, Labib RS, Voorhees JJ, Beals TF, Diaz LA (1982). Induction of pemphigus in neonatal mice by passive transfer of IgG from patients with the disease. N Engl J Med 306:1189–1192

    Article  CAS  PubMed  Google Scholar 

  4. Bedane C, McMillan JR, Balding SD et al. (1997) Bullous pemphigoid and cicatricial pemphigoid autoantibodies react with ultrastructurally separable epitopes on the BP180 ectodomain: evidence that BP180 spans the lamina lucida. J Invest Dermatol 108:901–917

    Article  CAS  PubMed  Google Scholar 

  5. Bhol K, Ahmed AR, Aoki V, Mohimen A, Nagarwalla N, Natarajan K (1995) Correlation of peptide specificity and IgG subclass with pathogenic and nonpathogenic autoantibodies in pemphigus vulgaris: a model for autoimmunity. Proc Natl Acad Sci USA 92:5239–5243

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  6. Borradori L, Caldwell JB, Briggaman RA, Burr CE, Gammon WR, James WD, Yancey KB (1995) Passive transfer of autoantibodies from a patient with mutilating epidermolysis bullosa acquisita induces specific alterations in the skin of neonatal mice. Arch Dermatol 131:590–595

    Article  CAS  PubMed  Google Scholar 

  7. Borradori L, Sonnenberg A (1999) Structure and function of hemidesmosomes: more than simple adhesion complexes. J Invest Dermatol 112:411–418

    Article  CAS  PubMed  Google Scholar 

  8. Büdinger L, Borradori L, Yee C et al. (1998) Identification and characterization of autoreactive T cell responses to bullous pemphigoid antigen 2 in patients and healthy controls. J Clin Invest 102:2082–2089

    Article  PubMed Central  PubMed  Google Scholar 

  9. Caldelari R, de Bruin A, Baumann D, Suter MM, Bierkamp C, Balmer V, Muller E (2001) A central role for the armadillo protein plakoglobin in the autoimmune disease pemphigus vulgaris. J Cell Biol 153:823–834

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  10. Chen M, Marinkovich MP, Jones JC, O'Toole E, Li YY, Woodley DT (1999) NC1 domain of type VII collagen binds to the beta3 chain of laminin 5 via a unique subdomain within the fibronectinlike repeats. J Invest Dermatol 112:177–183

    Article  CAS  PubMed  Google Scholar 

  11. Feliciani C, Toto P, Amerio P, Pour SM, Coscione G, Shivji G, Wang B, Sauder D (2000) In vitro and in vivo expression of interleukin-1alpha and tumor necrosis factor-alpha mRNA in pemphigus vulgaris: interleukin-1alpha and tumor necrosis factor-alpha are involved in acantholysis. J Invest Dermatol 114:71–77

    Article  CAS  PubMed  Google Scholar 

  12. Fine JD, Eady RAJ, Bauer EA et al. (2000) Revised classification system for inherited epidermolysis bullosa: report of the second international consensus meeting on diagnosis and classification of epidermolyxsis bullosa. J Am Acad Dermatol 42:1051–1066

    Article  CAS  PubMed  Google Scholar 

  13. Gammon WR, Briggaman RA (1993) Epidermolysis bullosa acquisita and bullous systemic lupus erythematosus. Diseases of autoimmunity to type VII collagen. Dermatol Clin 11:535–547

    Article  CAS  PubMed  Google Scholar 

  14. Giudice GJ, Emery DJ, Diaz LA (1992) Cloning and primary structural analysis of the bullous pemphigoid autoantigen BP180. J Invest Dermatol 99:243–250

    Article  CAS  PubMed  Google Scholar 

  15. Giudice GJ, Emery DJ, Zelickson BD, Anhalt GJ, Liu Z, Diaz LA (1993) Bullous pemphigoid and herpes gestationis autoantibodies recognize a common non-collagenous site on the BP180 ectodomain. J Immunol 151:5742–5750

    CAS  PubMed  Google Scholar 

  16. Guo L, Degenstein L, Dowling J-C, Yu QC, Wollmann R, Perman B, Fuchs E (1995) Gene targeting of BPAG1: abnormalities in mechanical strength and cell migration in stratified epithelia and neurologic degeneration. Cell 81:233–243

    Article  CAS  PubMed  Google Scholar 

  17. Hashimoto T, Gamou S, Korman NJ et al. (1995) Characterization of paraneoplastic pemphigus autoantigens by immunoblot analysis. J Invest Dermatol 104:829–834

    Article  CAS  PubMed  Google Scholar 

  18. Hintner H, Stingl G, Schuler G, Fritsch P, Stanley J, Katz S, Wolff K (1981) Immunofluorescence mapping of antigenic determinants within the dermal-epidermal junction in the mechanobullous diseases. J Invest Dermatol 76:113–118

    Article  CAS  PubMed  Google Scholar 

  19. Hofmann S, Thoma-Uszynski S, Hunziker T, Bernard P, Koebnick C, Stauber A, Borradori L, Hertl M (submitted) Autoantibodies against the N- and C-terminal regions of the BP180 ectodomain are associated with differences in phenotype and severity of bullous pemphigoid

  20. Koch PJ, Mahoney MG, Ishikawa H, Pulkkinen L, Uitto J, Shultz L, Murphy GF, Whitacker-Menezes D, Stanley JR (1997) Targeted disruption of the pemphigus vulgaris antigen (desmoglein 3) gene in mice causes loss of keratinocyte cell adhesion with a phenotype similar to pemphigus vulgaris. J Cell Biol 137:1091–1102

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  21. Liu Z, Diaz LA, Troy JL, Taylor AF, Emery DJ, Fairley JA, Giudice GJ (1993) A passive transfer model of the organ-specific autoimmune disease, bullous pemphigoid, using antibodies generated against the hemidesmosomal antigen, BP180. J Clin Invest 92:2480–2488

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  22. Mahoney MG, Wang Z, Rothenberger KL, Koch PJ, Amagai M, Stanley JR (1999) Explanation for localization of blisters in pemphigus patients. J Clin Invest 103:461–468

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  23. Nguyen VT, Ndoye A, Shultz LD, Pittelkow MR, Grando SA (2000) Antibodies against keratinocyte antigens other than desmogleins 1 and 3 can induce pemphigus vulgaris-like lesions. J Clin Invest 106:1467–1479

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  24. Schumann H, Baetge J, Tasanen K, Wojnarowska F, Schacke H, Zillikens D, Bruckner-Tuderman L (2000) The shed ectodomain of collagen XVII/BP180 is targeted by autoantibodies in different blistering skin diseases. Am J Pathol 156:685–695

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  25. Zillikens D, Rose PA, Balding SD, Liu Z, Olague-Marchan M, Diaz LA, Giudice GJ (1997) Tight clustering of extracellular BP180 epitopes recognized by bullous pemphigoid autoantibodies. J Invest Dermatol 109:573–579

    Article  CAS  PubMed  Google Scholar 

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Correspondence to Michael Hertl.

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Hertl, M., Schuler, G. Bullöse Autoimmundermatosen. Hautarzt 53, 277–287 (2002). https://doi.org/10.1007/s00105-002-0356-6

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