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Multimodale Therapie der lokalisierten High-grade-Weichgewebesarkome der Extremitäten

Zusammenfassung und Diskussion der aktuellen S3-Leitlinie „Adulte Weichgewebesarkome“ und der ESMO-Guideline „Soft tissue and visceral sarcomas“

Multimodal treatment of localized high-grade soft tissue sarcomas of the extremities

Summary and discussion of the current S3 guidelines on adult soft tissue sarcomas and the ESMO guidelines on soft tissue and visceral sarcomas

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Zusammenfassung

Weichgewebesarkome sind seltene, heterogene Tumore, welche häufig an den Extremitäten lokalisiert sind. Die Therapie beinhaltet die chirurgische Resektion, Kombinationschemotherapie und/oder Strahlentherapie sowie ergänzende Verfahren wie isolierte Extremitätenperfusion und regionale Tiefenhyperthermie. Die Prognose ist abhängig vom Tumorstadium und den etwa 70 histologischen Subtypen, wobei nur für einige Subtypen spezifische Therapieansätze existieren. Diese Übersichtsarbeit fasst die Empfehlungen der deutschen S3-Leitlinie „Adulte Weichgewebesarkome“ und der Leitlinie der European Society for Medical Oncology (ESMO) „Soft tissue and visceral sarcomas“ zur Diagnostik und Therapie lokalisierter Weichgewebesarkome der Extremitäten zusammen.

Abstract

Soft tissue sarcomas are rare, heterogeneous tumors that are frequently in the extremities. Treatment includes surgical resection, combination chemotherapy and/or radiotherapy, as well as supplementary procedures such as isolated limb perfusion and regional deep hyperthermia. The prognosis depends on the tumor stage and the approximately 70 histological subtypes, with specific treatment approaches existing only for some subtypes. This review summarizes the recommendations of the German S3 guideline “Adult Soft Tissue Sarcomas” and the European Society for Medical Oncology (ESMO) guideline “Soft tissue and visceral sarcomas” regarding the diagnostic workup and therapy of soft tissue sarcomas of the extremities.

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Authors and Affiliations

  1. Klinik und Poliklinik für Orthopädie, Unfallchirurgie und Plastische Chirurgie, Universitätsklinikum Leipzig, Liebigstraße 20, 04103, Leipzig, Deutschland

    Nikolas Schopow & Georg Osterhoff

  2. Sektion Spezielle chirurgische Onkologie und Thoraxchirurgie, Chirurgische Klinik, Universitätsklinikum Mannheim, Theodor-Kutzer-Ufer 1–3, 68167, Mannheim, Deutschland

    Peter Hohenberger

  3. Klinik für Viszeral‑, Transplantations‑, Thorax- und Gefäßchirurgie, Universitätsklinikum Leipzig, Liebigstraße 20, 04103, Leipzig, Deutschland

    Ines Gockel

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  1. Nikolas Schopow
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  2. Peter Hohenberger
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Correspondence to Georg Osterhoff.

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Interessenkonflikt

N. Schopow, P. Hohenberger, I. Gockel und G. Osterhoff geben an, dass kein Interessenkonflikt besteht.

Für diesen Beitrag wurden von den Autor/-innen keine Studien an Menschen oder Tieren durchgeführt. Für die aufgeführten Studien gelten die jeweils dort angegebenen ethischen Richtlinien.

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Schopow, N., Hohenberger, P., Gockel, I. et al. Multimodale Therapie der lokalisierten High-grade-Weichgewebesarkome der Extremitäten. Chirurgie 94, 424–431 (2023). https://doi.org/10.1007/s00104-023-01872-3

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