Skip to main content
Log in

Evidenz der Roboter-Chirurgie in der onkologischen Viszeralchirurgie

Evidence for robotic surgery in oncological visceral surgery

  • Leitthema
  • Published:
Der Chirurg Aims and scope Submit manuscript

Zusammenfassung

Die Überlegenheit minimal-invasiver Operationsmethoden gegenüber der offenen Chirurgie in Bezug auf verschiedene Parameter des Kurzzeitoutcomes mit adäquaten onkologischen Langzeitergebnissen wurde bereits bei vielen Tumorentitäten in hochqualitativen Studien belegt. Die immer weiter verbreitete Roboter-Chirurgie bietet in der minimal-invasiven onkologischen Viszeralchirurgie einige zusätzliche Vorteile, wie die hochauflösende dreidimensionale, stabile Sicht, vollständige Bewegungsfreiheit im Situs, Filterung des natürlichen Tremors und bessere Ergonomie. Dieser Artikel evaluiert nach Kriterien der evidenzbasierten Medizin, ob sich diese postulierten Vorteile in einer Verbesserung der kurzfristigen perioperativen und langfristigen onkologischen Ergebnisse gegenüber der herkömmlichen minimal-invasiven Chirurgie in der onkologischen Viszeralchirurgie (Rektum, Kolon, Magen, Ösophagus, Pankreas, Leber) niederschlagen. Mit Ausnahme der kolorektalen Chirurgie liegen in der onkologischen Viszeralchirurgie derzeit keine randomisiert-kontrollierten Studien (RCTs) zum Vergleich der robotischen mit der laparoskopischen Chirurgie bei viszeralonkologischen Krankheitsbildern vor. Es zeigt sich eine deutliche Diskrepanz zwischen der exponentiell zunehmenden Verbreitung des Operationsroboters und der noch unzureichenden Datenlage. Weitere RCTs sind insbesondere vor dem Hintergrund des großen technologischen Entwicklungspotenzials der robotischen Chirurgie dringend geboten.

Abstract

The superiority of minimally invasive operative methods compared to open surgery with respect to various parameters of short-term outcome with adequate oncological long-term results has already been confirmed for many tumor entities in high-quality studies. The continuously expanding robotic surgery offers certain additional benefits in minimally invasive oncological visceral surgery, such as a high-resolution stable 3‑dimensional view, optimal freedom of movement in situ, elimination of natural tremor and better ergonomics. This article evaluates whether these postulated advantages are reflected in an improvement of the short-term perioperative and long-term oncological results compared to conventional minimally invasive surgery in oncological visceral surgery (rectum, colon, stomach, esophagus, pancreas, liver) according to the criteria of evidence-based medicine. With the exception of colorectal surgery, there are currently no randomized controlled studies comparing robotic to laparoscopic surgery in oncological visceral surgery. There is still a clear imbalance between the exponentially expanding application of robotic surgery and the existing lack of high-quality evidence. Further randomized controlled clinical trials urgently need to be performed especially considering the great technological development potential of robotic surgery.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Abb. 1
Abb. 2
Abb. 3
Abb. 4

Literatur

  1. Guillou PJ, Quirke P, Thorpe H, Walker J, Jayne DG, Smith AM, Heath RM, Brown JM, M.C.t. group (2005) Short-term endpoints of conventional versus laparoscopic-assisted surgery in patients with colorectal cancer (MRC CLASICC trial): multicentre, randomised controlled trial. Lancet 365:1718–1726

    Article  Google Scholar 

  2. Jayne DG, Guillou PJ, Thorpe H, Quirke P, Copeland J, Smith AM, Heath RM, Brown JM, U.M.C.T. Group (2007) Randomized trial of laparoscopic-assisted resection of colorectal carcinoma: 3‑year results of the UK MRC CLASICC Trial Group. J Clin Oncol. 25:3061–3068

    Article  Google Scholar 

  3. Kirchberg J, Mees T, Weitz J (2016) Robotics in the operating room: out of the niche into widespread application. Chirurg 87:1025–1032

    Article  CAS  Google Scholar 

  4. Coughlin GD, Yaxley JW, Chambers SK, Occhipinti S, Samaratunga H, Zajdlewicz L, Teloken P, Dunglison N, Williams S, Lavin MF, Gardiner RA (2018) Robot-assisted laparoscopic prostatectomy versus open radical retropubic prostatectomy: 24-month outcomes from a randomised controlled study. Lancet Oncol 19:1051–1060

    Article  Google Scholar 

  5. Jayne D, Pigazzi A, Marshall H, Croft J, Corrigan N, Copeland J, Quirke P, West N, Rautio T, Thomassen N, Tilney H, Gudgeon M, Bianchi PP, Edlin R, Hulme C, Brown J (2017) Effect of robotic-assisted vs conventional laparoscopic surgery on risk of conversion to open laparotomy among patients undergoing resection for rectal cancer: the ROLARR randomized clinical trial. JAMA 318:1569–1580

    Article  Google Scholar 

  6. Yaxley JW, Coughlin GD, Chambers SK, Occhipinti S, Samaratunga H, Zajdlewicz L, Dunglison N, Carter R, Williams S, Payton DJ, Perry-Keene J, Lavin MF, Gardiner RA (2016) Robot-assisted laparoscopic prostatectomy versus open radical retropubic prostatectomy: early outcomes from a randomised controlled phase 3 study. Lancet 388:1057–1066

    Article  Google Scholar 

  7. Prete FP, Pezzolla A, Prete F, Testini M, Marzaioli R, Patriti A, Jimenez-Rodriguez RM, Gurrado A, Strippoli GFM (2018) Robotic versus laparoscopic minimally invasive surgery for rectal cancer: a systematic review and meta-analysis of randomized controlled trials. Ann Surg 267:1034–1046

    Article  Google Scholar 

  8. Debakey Y, Zaghloul A, Farag A, Mahmoud A, Elattar I (2018) Robotic-assisted versus conventional laparoscopic approach for rectal cancer surgery, first Egyptian academic center experience, RCT. Minim Invasive Surg 2018. https://doi.org/10.1155/2018/5836562

    Article  PubMed  PubMed Central  Google Scholar 

  9. Kim MJ, Park SC, Park JW, Chang HJ, Kim DY, Nam BH, Sohn DK, Oh JH (2018) Robot-assisted versus laparoscopic surgery for rectal cancer: a phase II open label prospective randomized controlled trial. Ann Surg 267:243–251

    Article  Google Scholar 

  10. Ma S, Chen Y, Chen Y, Guo T, Yang X, Lu Y, Tian J, Cai H (2018) Short-term outcomes of robotic-assisted right colectomy compared with laparoscopic surgery: a systematic review and meta-analysis. Asian J Surg. https://doi.org/10.1016/j.asjsur.2018.11.002

    Article  PubMed  Google Scholar 

  11. Park JS, Choi GS, Park SY, Kim HJ, Ryuk JP (2012) Randomized clinical trial of robot-assisted versus standard laparoscopic right colectomy. Br J Surg 99:1219–1226

    Article  CAS  Google Scholar 

  12. Park JS, Kang H, Park SY, Kim HJ, Woo IT, Park IK, Choi GS (2018) Long-term oncologic after robotic versus laparoscopic right colectomy: a prospective randomized study. Surg Endosc. https://doi.org/10.1007/s00464-018-6563-8

    Article  PubMed  Google Scholar 

  13. Chen K, Pan Y, Zhang B, Maher H, Wang XF, Cai XJ (2017) Robotic versus laparoscopic gastrectomy for gastric cancer: a systematic review and updated meta-analysis. BMC Surg 17:93

    Article  Google Scholar 

  14. Pan JH, Zhou H, Zhao XX, Ding H, Qin L, Pan YL (2017) Long-term oncological outcomes in robotic gastrectomy versus laparoscopic gastrectomy for gastric cancer: a meta-analysis. Surg Endosc 31:4244–4251

    Article  Google Scholar 

  15. Pan HF, Wang G, Liu J, Liu XX, Zhao K, Tang XF, Jiang ZW (2017) Robotic versus laparoscopic gastrectomy for locally advanced gastric cancer. Surg Laparosc Endosc Percutan Tech 27:428–433

    Article  Google Scholar 

  16. Wang WJ, Li HT, Yu JP, Su L, Guo CA, Chen P, Yan L, Li K, Ma YW, Wang L, Hu W, Li YM, Liu HB (2018) Severity and incidence of complications assessed by the Clavien-Dindo classification following robotic and laparoscopic gastrectomy for advanced gastric cancer: a retrospective and propensity score-matched study. Surg Endosc. https://doi.org/10.1007/s00464-018-06624-7

    Article  PubMed  PubMed Central  Google Scholar 

  17. Uyama I, Suda K, Nakauchi M, Kinoshita T, Noshiro H, Takiguchi S, Ehara K, Obama K, Kuwabara S, Okabe H, Terashima M (2018) Clinical advantages of robotic gastrectomy for clinical stage I/II gastric cancer: a multi-institutional prospective single-arm study. Gastric Cancer https://doi.org/10.1007/s10120-018-00906-8 (Epub ahead of print)

    Article  PubMed  Google Scholar 

  18. van der Sluis PC, Ruurda JP, van der Horst S, Verhage RJ, Besselink MG, Prins MJ, Haverkamp L, Schippers C, Rinkes IH, Joore HC, Ten FJK, Koffijberg H, Kroese CC, van Leeuwen MS, Lolkema MP, Reerink O, Schipper ME, Steenhagen E, Vleggaar FP, Voest EE, Siersema PD, van Hillegersberg R (2012) Robot-assisted minimally invasive thoraco-laparoscopic esophagectomy versus open transthoracic esophagectomy for resectable esophageal cancer, a randomized controlled trial (ROBOT trial). Trials 13:230

    Article  Google Scholar 

  19. van der Sluis PC, van der Horst S, May AM, Schippers C, Brosens LAA, Joore HCA, Kroese CC, Haj NM, Mook S, Vleggaar FP, Borel Rinkes IHM, Ruurda JP, van Hillegersberg R (2018) Robot-assisted minimally invasive thoracolaparoscopic esophagectomy versus open transthoracic esophagectomy for resectable esophageal cancer: a randomized controlled trial. Ann Surg. https://doi.org/10.1097/SLA.0000000000003031 (Epub ahead of print)

    Article  Google Scholar 

  20. van der Sluis PC, Ruurda JP, Verhage RJ, van der Horst S, Haverkamp L, Siersema PD, Borel Rinkes IH, Ten FJK, van Hillegersberg R (2015) Oncologic long-term results of robot-assisted minimally invasive thoraco-laparoscopic esophagectomy with two-field lymphadenectomy for esophageal cancer. Ann Surg Oncol 22(3):S1350–S1356

    Article  Google Scholar 

  21. de la Fuente SG, Weber J, Hoffe SE, Shridhar R, Karl R, Meredith KL (2013) Initial experience from a large referral center with robotic-assisted Ivor Lewis esophagogastrectomy for oncologic purposes. Surg Endosc 27:3339–3347

    Article  Google Scholar 

  22. Cerfolio RJ, Wei B, Hawn MT, Minnich DJ (2016) Robotic esophagectomy for cancer: early results and lessons learned. Semin Thorac Cardiovasc Surg 28:160–169

    Article  Google Scholar 

  23. Weksler B, Sharma P, Moudgill N, Chojnacki KA, Rosato EL (2012) Robot-assisted minimally invasive esophagectomy is equivalent to thoracoscopic minimally invasive esophagectomy. Dis Esophagus 25:403–409

    Article  CAS  Google Scholar 

  24. He H, Wu Q, Wang Z, Zhang Y, Chen N, Fu J, Zhang G (2018) Short-term outcomes of robot-assisted minimally invasive esophagectomy for esophageal cancer: a propensity score matched analysis. J Cardiothorac Surg 13:52

    Article  Google Scholar 

  25. Zhou JY, Xin C, Mou YP, Xu XW, Zhang MZ, Zhou YC, Lu C, Chen RG (2016) Robotic versus laparoscopic distal pancreatectomy: a meta-analysis of short-term outcomes. PLoS ONE 11:e151189

    Article  Google Scholar 

  26. Guerrini GP, Lauretta A, Belluco C, Olivieri M, Forlin M, Basso S, Breda B, Bertola G, Di Benedetto F (2017) Robotic versus laparoscopic distal pancreatectomy: an up-to-date meta-analysis. BMC Surg 17:105

    Article  Google Scholar 

  27. Strijker M, van Santvoort HC, Besselink MG, van Hillegersberg R, Borel Rinkes IH, Vriens MR, Molenaar IQ (2013) Robot-assisted pancreatic surgery: a systematic review of the literature. HPB (Oxford) 15:1–10

    Article  Google Scholar 

  28. Zureikat AH, Moser AJ, Boone BA, Bartlett DL, Zenati M, Zeh HJ 3rd (2013) 250 robotic pancreatic resections: safety and feasibility. Ann Surg 258:554–559 (discussion 559–562)

    PubMed  PubMed Central  Google Scholar 

  29. Montalti R, Berardi G, Patriti A, Vivarelli M, Troisi RI (2015) Outcomes of robotic vs laparoscopic hepatectomy: a systematic review and meta-analysis. World J Gastroenterol 21:8441–8451

    Article  Google Scholar 

  30. Tsilimigras DI, Moris D, Vagios S, Merath K, Pawlik TM (2018) Safety and oncologic outcomes of robotic liver resections: a systematic review. J Surg Oncol 117:1517–1530

    Article  Google Scholar 

  31. Berber E, Akyildiz HY, Aucejo F, Gunasekaran G, Chalikonda S, Fung J (2010) Robotic versus laparoscopic resection of liver tumours. HPB (Oxford) 12:583–586

    Article  Google Scholar 

  32. Lai EC, Tang CN (2016) Long-term survival analysis of robotic versus conventional laparoscopic hepatectomy for hepatocellular carcinoma: a comparative study. Surg Laparosc Endosc Percutan Tech 26:162–166

    Article  Google Scholar 

  33. Troisi RI, Patriti A, Montalti R, Casciola L (2013) Robot assistance in liver surgery: a real advantage over a fully laparoscopic approach? Results of a comparative bi-institutional analysis. Int J Med Robot 9:160–166

    Article  Google Scholar 

  34. Montalti R, Scuderi V, Patriti A, Vivarelli M, Troisi RI (2016) Robotic versus laparoscopic resections of posterosuperior segments of the liver: a propensity score-matched comparison. Surg Endosc 30:1004–1013

    Article  Google Scholar 

  35. Kissler HJ, Bauschke A, Settmacher U (2016) First national survey on use of robotics for visceral surgery in Germany. Chirurg 87:669–675

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to J. Kirchberg.

Ethics declarations

Interessenkonflikt

J. Weitz gibt Forschungsunterstützung durch Intuitive Surgical an. J. Kirchberg gibt Forschungsunterstützung durch Intuitive Surgical an.

Dieser Beitrag beinhaltet keine von den Autoren durchgeführten Studien an Menschen oder Tieren.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Kirchberg, J., Weitz, J. Evidenz der Roboter-Chirurgie in der onkologischen Viszeralchirurgie. Chirurg 90, 379–386 (2019). https://doi.org/10.1007/s00104-019-0812-9

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00104-019-0812-9

Schlüsselwörter

Keywords

Navigation