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Definition der R1-Resektion bei Schilddrüsenkarzinomen

Definition of R1 resection in thyroid carcinoma

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Zusammenfassung

Hintergrund

Die Residualtumor(R)-Klassifikation beschreibt den Tumorstatus nach einer Therapie, d. h. bei Patienten mit Schilddrüsenkarzinomen vorwiegend nach einer chirurgischen Therapie. Das Ziel ist, den Erfolg der (chirurgischen) Therapie anzugeben, was das weitere therapeutische Vorgehen beeinflussen kann und relevante prognostische Aussagen erlaubt.

Fragestellung

Definition der R1-Resektion als auch des minimal invasiven extrathyreoidalen Wachstums von Schilddrüsenkarzinomen als häufige Voraussetzung einer R1-Resektion.

Ergebnisse

Darstellung der pathologischen Aufarbeitung und histopathologischen Beurteilung. Vorschlag zur Ergänzung und Erweiterung der seit 2017 gültigen TNM-Klassifikation (8. Auflage), um minimal invasive extrathyreoidale Schilddrüsenkarzinome systematisch klassifizieren zu können.

Schlussfolgerungen

Die dargestellten Definitionen (R1, minimal invasives extrathyreoidales Wachstum) in Verbindung mit der vorgeschlagenen Erweiterung der TNM-Klassifikation erlauben die prospektive wissenschaftliche Bewertung der biologischen Relevanz der beiden Parameter.

Abstract

Background

The residual tumor (R) classification describes the tumor status after therapy, which in patients with thyroid carcinomas is predominantly after surgical treatment. The aim of the R classification is to indicate the success of (surgical) therapy, which can influence further therapeutic procedures and allow relevant prognostic statements.

Objective

Definition of R1 resection as well as minimally invasive extrathyroidal growth of thyroid carcinomas as the latter is a common prerequisite for R1 resected thyroid carcinoma.

Results

Presentation of the pathological work-up and histopathological assessment. Proposal to supplement and extend the recently introduced 8th edition of the TNM classification in order to systematically classify minimally invasive extrathyroidal carcinomas.

Conclusion

The presented definitions (e.g. R1, minimally invasive extrathyroidal invasion) in combination with the proposed extension of the TNM classification permit the prospective scientific assessment of the biological relevance of these two parameters.

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Authors and Affiliations

  1. Institut für Pathologie, Universitätsklinikum Essen, Universität Duisburg-Essen, Hufelandstraße 55, 45147, Essen, Deutschland

    S. Synoracki &  K. W. Schmid

  2. Institut für Pathologie, Universitätsklinikum Leipzig, Leipzig, Deutschland

    Ch. Wittekind

  3. Klinik für Allgemeinchirurgie, Viszeral- und Transplantationschirurgie, Universitätsklinikum Essen, Universität Duisburg-Essen, Essen, Deutschland

    H. Dralle

  4. Westdeutsches Tumorzentrum Essen (WTZ), Essen, Deutschland

    K. W. Schmid

Authors
  1. S. Synoracki
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  2. Ch. Wittekind
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  3. H. Dralle
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  4. K. W. Schmid
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Corresponding author

Correspondence to K. W. Schmid.

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Interessenkonflikt

S. Synoracki, C. Wittekind, H. Dralle und K.W. Schmid geben an, dass kein Interessenkonflikt besteht.

Dieser Beitrag beinhaltet keine von den Autoren durchgeführten Studien an Menschen oder Tieren.

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Synoracki, S., Wittekind, C., Dralle, H. et al. Definition der R1-Resektion bei Schilddrüsenkarzinomen. Chirurg 88, 740–747 (2017). https://doi.org/10.1007/s00104-017-0461-9

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  • DOI: https://doi.org/10.1007/s00104-017-0461-9

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