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Präfabrikation von Herzklappen

Prefabrication of heart valves

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Zusammenfassung

Hintergrund

Konventionelle Prothesen für den Herzklappenersatz haben Nachteile und Einschränkungen.

Fragestellung und Methode

Die Nutzbarmachung von Prinzipien des Tissueengineerings zur Optimierung aktuell gängiger Klappenersatzverfahren wird dargestellt.

Ergebnis und Schlussfolgerung

Die Studienlage der letzten Jahre hat gezeigt, dass allogene, dezellularisierte Herzklappen die Limitationen herkömmlicher Prothesen überwinden und die Charakteristika eines idealen Klappenersatzes gewährleisten können.

Abstract

Background

Commonly used heart valve prostheses have specific drawbacks and limitations.

Objectives and methods

Optimization of conventional methods and techniques for heart valve replacement by application of tissue engineering principles.

Results and conclusions

Recent studies have impressively shown that allogeneic decellularized matrices have the potential to overcome limitations of conventional prostheses and to provide all the characteristics of an ideal graft for heart valve replacement.

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Literatur

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Einhaltung ethischer Richtlinien

Interessenkonflikt. T. Goecke, I. Tudorache, A. Hilfiker, A. Haverich und S. Cebotari geben an, dass kein Interessenkonflikt besteht. Dieser Beitrag beinhaltet keine Studien an Menschen oder Tieren.

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Authors and Affiliations

  1. Klinik für Herz-, Thorax-, Transplantation- und Gefäßchirurgie, Medizinische Hochschule Hannover, Carl Neuberg Str. 1, 30625, Hannover, Deutschland

    T. Goecke, I. Tudorache, A. Hilfiker, A. Haverich &  S. Cebotari

Authors
  1. T. Goecke
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  2. I. Tudorache
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  3. A. Hilfiker
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  4. A. Haverich
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  5. S. Cebotari
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Corresponding author

Correspondence to S. Cebotari.

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Goecke, T., Tudorache, I., Hilfiker, A. et al. Präfabrikation von Herzklappen. Chirurg 86, 251–253 (2015). https://doi.org/10.1007/s00104-014-2831-x

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  • DOI: https://doi.org/10.1007/s00104-014-2831-x

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