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Lebertransplantation beim hilären Cholangiokarzinom

Liver transplantation for hilar cholangiocarcinoma

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Zusammenfassung

Lokal nichtresektable hiläre Cholangiokarzinome können durch Lebertransplantation kurativ therapiert werden. Die ursprünglich schlechten Ergebnisse nach Transplantation haben sich durch die Etablierung neoadjuvanter Therapieprotokolle und veränderte Strategien in der immunsuppressiven Therapie deutlich verbessert, sodass perihiläre Cholangiokarzinome nun wieder als Transplantationsindikation anerkannt werden. Geeignete Patienten sollten streng selektioniert werden. Die vorliegende Arbeit fasst den aktuellen Stand, Empfehlungen und die Ergebnisse der Lebertransplantation bei diesen Patienten zusammen.

Abstract

Local non-resectable, hilar cholangiocarcinoma can be cured by performing a liver transplantation. The initially poor results after transplantation have significantly improved since neoadjuvant therapy protocols have been established. Therefore, hilar cholangiocarcinoma is now an accepted indication for liver transplantation in selected patients. This article summarizes the current state, recommendations and results of liver transplantation for these patients.

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Authors and Affiliations

  1. Klinik für Allgemein-, Viszeral- und Gefäßchirurgie, Universitätsklinikum Jena, Erlanger Allee 101, 07747, Jena, Deutschland

    F. Rauchfuß, F. Uteß, S. Schüle, Y. Dittmar, H. Scheuerlein & U. Settmacher

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  1. F. Rauchfuß
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  2. F. Uteß
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  3. S. Schüle
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  4. Y. Dittmar
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  5. H. Scheuerlein
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  6. U. Settmacher
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Correspondence to F. Rauchfuß.

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Rauchfuß, F., Uteß, F., Schüle, S. et al. Lebertransplantation beim hilären Cholangiokarzinom. Chirurg 83, 229–237 (2012). https://doi.org/10.1007/s00104-011-2178-5

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