Zusammenfassung
Durch eine perioperative Antibiotikaprophylaxe können bei gegebener Indikation postoperative Infektionen sicher und wirksam vermieden werden. Die bisher gültige Leitlinie (S1) der Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften (AWMF) von 2004 wurde 2010 durch die Empfehlungen einer Expertenkommission der Paul-Ehrlich-Gesellschaft für Chemotherapie e.V. (PEG) ersetzt, in der neueste Daten von 2000 bis 2008 berücksichtigt wurden. Die Indikation und Auswahl der entsprechenden Antibiotika orientiert sich an patientenabhängigen und operationsspezifischen Risikofaktoren. Dieser Artikel stellt die aktuellen Empfehlungen der PEG für die Allgemein- und Viszeralchirurgie dar.
Abstract
The use of prophylactic perioperative antibiotic therapy if indicated could successfully and safely prevent surgical wound infections. The current guidelines (S1) for prophylactic perioperative antibiotic therapy of the Study Group of the Scientific Medical Associations (AWMF) of 2004 was replaced by a recommendation of the study group of the Paul-Ehrlich-Gesellschaft for Chemotherapy (PEG) in 2010. This recommendation includes recent research data from 2000 to 2008. Indications and choice of antibiotic agent depend on specific risk factors of the patient and the operation performed. The aim of this article is to describe the current recommendations of the PEG for general and visceral surgery.
Literatur
Gastmeier P, Brandt C, Sohr D et al (2004) Surgical site infections in hospitals and outpatient settings. Results of the German nosocomial infection surveillance system (KISS). Bundesgesundheitsbl Gesundheitsforsch Gesundheitsschutz 47(4):339–344
Bratzler DW, Houck PM (2004) Antimicrobial prophylaxis for surgery: an advisory statement from the National Surgical Infection Prevention Project. Clin Infect Dis 38(12):1706–1715
Rovera F, Diurni M, Dionigi G et al (2005) Antibiotic prophylaxis in colorectal surgery. Expert Rev Anti Infect Ther 3(5):787–795
Barie PS (2002) Surgical site infections: epidemiology and prevention. Surg Infect 3(Suppl 1):9–21
Wacha HHU, Isenmann R, Kujath P et al (2010) Perioperative Antibiotika-Prophylaxe. Chemother J 19:70–84
Zelenitsky SA, Silverman RE, Duckworth H, Harding GK (2000) A prospective, randomized, double-blind studyof single high dose versus multiple standard dose gentamicin both in combination withmetronidazole for colorectal surgicalprophylaxis. J Hosp Infect 46(2):135–140
Zelenitsky SA, Ariano RE, Harding GK, Silverman RE (2002) Antibiotic pharmacodynamics in surgical prophylaxis: an association between intraoperative antibiotic concentrations and efficacy. Antimicrob Agents Chemother 46(9):3026–3030
Matsuda K, Hotta T, Takifuji K et al (2009) Long-term comorbidity of diabetes mellitus is a risk factor for perineal wound complications after an abdominoperineal resection. Langenbecks Arch Surg 394(1):65–70
Pessaux P, Atallah D, Lermite E et al (2005) Risk factors for prediction of surgical site infections in „clean surgery“. Am J Infect Control 33(5):292–298
Chaberny IF, Wriggers A, Behnke M, Gastmeier P (2010) Antibiotics: MRSA prevention measures in German hospitals: results of a survey among hospitals, performed as part of the MRSA-KISS module. Dtsch Arztebl Int 107(37):631–637
Finkelstein R, Rabino G, Mashiah T et al (2002) Vancomycin versus cefazolin prophylaxis for cardiac surgery in the setting of a high prevalence of methicillin-resistant staphylococcal infections. J Thorac Cardiovasc Surg 123(2):326–332
Perl TM, Roy MC (1995) Postoperative wound infections: risk factors and role of Staphylococcus aureus nasal carriage. J Chemother 7(Suppl 3):29–35
Itani KM, Wilson SE, Awad SS et al (2006) Ertapenem versus cefotetan prophylaxis in elective colorectal surgery. N Engl J Med 355(25):2640–2651
Khan AA MA, Qadir A (2006) Comparison of etiology and rate of infection in different surgical wounds. Med Forum Month 17:10–16
Salehi OA, Karimi A, Ahmadi SH et al (2007) Superficial and deep sternal wound infection after more than 9000 coronary artery bypass graft (CABG): incidence, risk factors and mortality. BMC Infect Dis 7:112
Classen DC, Evans RS, Pestotnik SL et al (1992) The timing of prophylactic administration of antibiotics and the risk of surgical-wound infection. N Engl J Med 326(5):281–286
Gislason H, Soreide O, Viste A (1999) Wound complications after major gastrointestinal operations. The surgeon as a risk factor. Dig Surg 16(6):512–514
Medina M, Sillero M, Martinez-Gallego G, Delgado-Rodriguez M (1997) Risk factors of surgical wound infection in patients undergoing herniorrhaphy. Eur J Surg 163(3):191–198
Seiler CM, Bruckner T, Diener MK et al (2009) Interrupted or continuous slowly absorbable sutures for closure of primary elective midline abdominal incisions: a multicenter randomized trial (INSECT: ISRCTN24023541). Ann Surg 249(4):576–582
Ramos G, Resta M, Machare Delgado E et al (2008) Systemic perioperative antibiotic prophylaxis may improve skin autograft survival in patients with acute burns. J Burn Care Res 29(6):917–923
Kehlet H (2008) Fast-track colorectal surgery. Lancet 371(9615):791–793
Zaydfudim V, Russell RT, Feurer ID et al (2009) Drain use after open cholecystectomy: is there a justification? Langenbecks Arch Surg 394(6):1011–1017
Bates T, Siller G, Crathern BC et al (1989) Timing of prophylactic antibiotics in abdominal surgery: trial of a pre-operative versus an intra-operative first dose. Br J Surg 76(1):52–56
Weber WP, Marti WR, Zwahlen M et al (2008) The timing of surgical antimicrobial prophylaxis. Ann Surg 247(6):918–926
Hutschala D, Skhirtladze K, Kinstner C et al (2007) In vivo microdialysis to measure antibiotic penetration into soft tissue during cardiac surgery. Ann Thorac Surg 84(5):1605–1610
Mohri Y, Tonouchi H, Kobayashi M et al (2007) Randomized clinical trial of single- versus multiple-dose antimicrobial prophylaxis in gastric cancer surgery. Br J Surg 94(6):683–688
Catarci M, Mancini S, Gentileschi P et al (2004) Antibiotic prophylaxis in elective laparoscopic cholecystectomy. Lack of need or lack of evidence? Surg Endosc 18(4):638–641
Higgins A, London J, Charland S et al (1999) Prophylactic antibiotics for elective laparoscopic cholecystectomy: are they necessary? Arch Surg 134(6):611–614
Illig KA, Schmidt E, Cavanaugh J et al (1997) Are prophylactic antibiotics required for elective laparoscopic cholecystectomy? J Am Coll Surg 184(4):353–356
Chen LF, Anderson DJ, Hartwig MG et al (2008) Surgical site infections after laparoscopic and open cholecystectomies in community hospitals. Infect Control Hosp Epidemiol 29(1):92–94; author reply 4–5
Chuang SC, Lee KT, Chang WT et al (2004) Risk factors for wound infection after cholecystectomy. J Formos Med Assoc 103(8):607–612
Nelson RL, Glenny AM, Song F (2009) Antimicrobial prophylaxis for colorectal surgery. Cochrane Database Syst Rev (1):CD001181
Song F, Glenny AM (1998) Antimicrobial prophylaxis in colorectal surgery: a systematic review of randomized controlled trials. Br J Surg 85(9):1232–1241
Guenaga KK, Matos D, Wille-Jorgensen P (2009) Mechanical bowel preparation for elective colorectal surgery. Cochrane Database Syst Rev (1):CD001544
Espin-Basany E, Sanchez-Garcia JL, Lopez-Cano M et al (2005) Prospective, randomised study on antibiotic prophylaxis in colorectal surgery. Is it really necessary to use oral antibiotics? Int J Colorectal Dis 20(6):542–546
Fry DE (2008) Surgical site infections and the surgical care improvement project (SCIP): evolution of national quality measures. Surg Infect 9(6):579–584
Andersen BR, Kallehave FL, Andersen HK (2005) Antibiotics versus placebo for prevention of postoperative infection after appendicectomy. Cochrane Database Syst Rev (3):CD001439
Tamayo E, Gualis J, Florez S et al (2008) Comparative study of single-dose and 24-hour multiple-dose antibiotic prophylaxis for cardiac surgery. J Thorac Cardiovasc Surg 136(6):1522–1527
Sanabria A, Dominguez LC, Valdivieso E, Gomez G (2007) Prophylactic antibiotics for mesh inguinal hernioplasty: a meta-analysis. Ann Surg 245(3):392–396
Cruse PJ, Foord R (1980) The epidemiology of wound infection. A 10-year prospective study of 62,939 wounds. Surg Clin North Am 60(1):27–40
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Knebel, P., Weigand, M., Büchler, M. et al. Evidenzbasierte Antibiotikaprophylaxe in der Allgemein- und Viszeralchirurgie. Chirurg 82, 227–234 (2011). https://doi.org/10.1007/s00104-010-2011-6
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DOI: https://doi.org/10.1007/s00104-010-2011-6
Schlüsselwörter
- Perioperative Antibiotikaprophylaxe
- Chemotherapie
- Infektionsprophylaxe
- Postoperativer Wundinfekt
- Paul-Ehrlich-Gesellschaft