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Lebendspende-Nierentransplantation

Living-donor kidney transplantation

Der Chirurg volume 81, pages 794–803 (2010)Cite this article

Zusammenfassung

Aufgrund des bestehenden Organmangels ist trotz der Option einer Nierentransplantation (NTPL) bei Patienten mit einer Nierenerkrankung im Endstadium die Durchführung dieser Therapie nicht immer möglich. Durch die Leichenspende kann leider bis dato die notwendige Anzahl an NTPL nicht adäquat abgedeckt werden. Zur Lösung dieses Problems haben sich bereits in vielen Transplantationszentren Programme für die Lebendspende-NTPL etabliert. In repräsentativen Arbeiten konnte gezeigt werden, dass hinsichtlich der Transplantatfunktion und dem Patientenüberleben das Lebendspendeprogramm im Vergleich zur Kadaverspende-NTPL bessere Ergebnisse erzielen kann. Somit ermöglicht die Lebendspende-NTPL eine gute Alternative zur Unterstützung des Organpools. Ziel dieses Berichtes ist es, die Langzeitergebnisse des Heidelberger Lebendspende-NTPL-Programms hinsichtlich der Transplantatfunktion und des Patientenüberlebens darzustellen sowie im Kontext der Erfahrungen anderer Zentren die Risiken der Lebendspende zu diskutieren.

Abstract

Due to the existing organ shortage the option of a kidney transplantation (KTx) in patients with end-stage renal disease is not always possible despite the offer of this therapy. So far the required number of KTx could not be adequately achieved by organ donations from deceased persons. To solve this problem living donation KTx programs have already become established in many transplantation centers. In published reports it has been shown that with the living donation program better results could be achieved in terms of graft function and patient survival compared to cadaver donation KTx. Therefore, living donation KTx allows an optimal alternative to expand the organ pool. The aim of our study is to present the long-term results of our living donation KTx program regarding graft function and patient survival. Finally, the risks of living donation KTx will be discussed based on the reported experiences of other centers.

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Affiliations

  1. Klinik für Allgemein-, Viszeral- und Transplantationschirurgie, Chirurgische Universitätsklinik Heidelberg, Im Neuenheimer Feld 110, 69120, Heidelberg, Deutschland

    A. Mehrabi FEBS, FICS, H. Fonouni, M. Golriz, B. Schmied, M. Tahmasbirad, J. Weitz, M.W. Büchler, M. Zeier & J. Schmidt

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  1. A. Mehrabi FEBS, FICS
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  2. H. Fonouni
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  3. M. Golriz
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  4. B. Schmied
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  5. M. Tahmasbirad
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  6. J. Weitz
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  7. M.W. Büchler
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  8. M. Zeier
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  9. J. Schmidt
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Correspondence to A. Mehrabi FEBS, FICS.

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Mehrabi, A., Fonouni, H., Golriz, M. et al. Lebendspende-Nierentransplantation. Chirurg 81, 794–803 (2010). https://doi.org/10.1007/s00104-009-1873-y

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  • DOI: https://doi.org/10.1007/s00104-009-1873-y

Schlüsselwörter

  • Nierentransplantation
  • Organmangel
  • Lebendspende
  • Langzeitergebnisse
  • Transplantatfunktion

Keywords

  • Kidney transplantation
  • Organ shortage
  • Living donation
  • Long-term results
  • Graft function